Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"developmental neuroscience"”.
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Executive Functioning as a Mediator of Relations Between Neural Structure and General Psychopathology in Pre-Adolescents
… was only associated with the internalizing, neurodevelopmental, and general factors. Additionally, compared to IC, WM was a stronger mediator of relations between a wider range of GMV regions and the psychopathology factors. Indirect effects were negative for the externalizing, neurodevelopmental, …
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Beta EEG as a Correlate of Belief-Reasoning in Preschoolers
Reasoning about beliefs is difficult, especially when others hold beliefs that conflict with one’s own. A milestone in Theory of Mind development is understanding false beliefs: the realization that others may hold representations of the world that differ from one’s own perspective (Wellman & …
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P120-Catenin Subfamily Members Have Distinct As Well As Shared Effects On Dendrite Morphology During Neuron Development In Vitro
<p>Proper dendrite morphology is essential for neuronal connectivity and function, and abnormal dendrite morphology is seen in many neurological pathologies. This study characterizes and compares the effects of a group of four proteins – the p120-catenin subfamily – that regulate cytoskeletal …
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A computational and experimental study of the Drosophila larval locomotor system and its developmental critical period
… lasting maladjustment. In humans, several neurodevelopmental conditions, including forms of epilepsy and schizophrenia, have been linked to suboptimal critical periods. How networks adjust during a critical period, or how they are changed following critical period perturbations, is not well …
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Ephrin Receptors, AIY Interneuron Physiology, and Behavior
<p>In order to survive, an organism must be able to receive, integrate, and respond to sensory stimuli. However, the cellular basis of sensory perception and response is difficult to study in complex animals such as humans, and is therefore poorly understood. The nematode <em>Caenorhabditis …
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Reality Resists Classification: A Transdiagnostic, Network-Based Approach to Behavioural and Neural Variation in Childhood
… biological and environmental phenomena. Key developmental outcomes, such as cognitive ability and behaviour, are closely associated with the structure and function of the brain. These features of neurobiology are shaped concurrently by genetic factors, individuals’ interactions with the …
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The Short and Long-Term Effects of Chronic Ketamine during Adolescence on Object Recognition Memory in Rats
… different kinds of drugs during the critical developmental period of adolescence can lead to impairments in cognition later in adulthood (Gilpin et al., 2012; Wagner et al., 2010), no research has investigated the effects of chronic ketamine administration during adolescence and its effects on …
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Examining the Appropriate Recovery Interval Following Maximal Exertion for Baseline Computerized Neurocognitive Testing (CNT)
<p>Background: Computerized neurocognitive testing is part of the recommended multi-faceted approach to SRC assessment. Prior research has suggested that maximal exertion negatively effects CNT test scores. Purpose: To identify the appropriate timing of the administration of CNT following maximal …
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Mechanisms and Targeting of Neurodevelopmental Regulator Rest In Medulloblastoma Dissemination
<p>Molecular subgrouping of medulloblastoma (MB) has produced four subgroups: wingless (WNT), sonic hedgehog (SHH), group 3, and group 4. While patients with WNT tumors have the best prognosis, patients with SHH tumors have a more variable prognosis concurrent with metastatic disease. This subset …
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Neural Development to Neurodegeneration Through the Mind of a Worm
<p>Defects in the nervous system can impact the normal function of an organism. By examining mutations during neuronal development, we can better understand the significance of specific pathways. The EphR/ephrin pathway is crucial for axonal guidance during development. The simple organism, <em>C. …
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Targeting AMPA Receptor Modulation during Early Life Adversity: A Mediator for Threat Associated Memories
… the role of threat associated AMPAr on developmental synaptic plasticity by <em>1. Utilization of age-specific threat conditioning paradigms 2. Monitoring biochemical changes 3. Examining the influence of stress hormones. These experiments</em> <em>focused on identifying AMPAr as a …
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Decoding the Little Skate Retina: Structural Variants and Developmental Dynamics
… expression of the gene itself, varying across developmental stages. The implications of this finding are not yet entirely clear, but there is precedence for the discovery of alternative splicing of this gene into two isoforms, as the report on the initial discovery of this gene found two …
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Developmental Changes In The Structure and Composition of The Postsynaptic Density
… store information. At the ultrastructural level, developmental and activity-dependent changes in the size and shape of dendritic spines have been well documented, and it is widely believed that structural changes in spines are a hallmark sign of synapse maturation and alteration of synaptic …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
<p>Neonates are highly susceptible to infections in the central nervous system (CNS) and have a greater risk of viral infections and encephalopathies. Neurotropic viral infections can lead to blindness, hearing loss and neurological deficiencies such as cognitive impairment, epilepsy, and even …
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Characterizing and Treating The Neuropathology of Tuberous Sclerosis Complex In The Mouse
… affecting approximately 1 in 6000 births. Developmental brain abnormalities cause substantial morbidity and mortality and often lead to neurological disease including epilepsy, cognitive disabilities, and autism. TSC is caused by inactivating mutations in either <em>TSC1</em> or …
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The Role of Vps54 in Drosophila melanogaster Neuronal Development and Age Progressive Neurodegeneration
<p>Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN). The “wobbler” mouse is the phenotypic result of a destabilizing point mutation in Vps54. This mutation causes neurodegeneration …
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Modeling 3D Retinogenesis in Mouse Embryonic Stem Cells Following CRISPR-mediated Crx Knockdown
… factor CRX, which is known to regulate key developmental decisions during retinogenesis, and as such, mutations in CRX have resulted in various diseases such as Leber Congenital Amaurosis, Cone-Rod Dystrophy, and Retinitis Pigmentosa.</p>
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Brainwaves, Memory, and Reward
<p>The development of effective educational curricula for enhancing learning involves the crucial consideration of effort and rewards. In the realm of education, teachers commonly employ rewards as motivational tools. Traditionally, these rewards are given to students as a recognition of their …
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Underlying Contribution of Executive Functioning to Cognition and Academic Achievement in Individuals with Dystrophinopathy
<p>Dystrophinopathy is a genetic disorder that results in the lack of or abnormal expression of the protein dystrophin. It is a disorder that alters cell structure and function, impacts the developing brain and brain function, presents with multi-domain cognitive deficits, and influences both mood …
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A Novel Switch-Like Function of Delta-Catenin In Dendrite Development
… connectivity associated with multiple neurodevelopmental diseases. My research addresses molecular processes that underlie dendritogenesis via analysis of a pair of novel interactions involving the protein delta-catenin.</p> <p>In neurons, delta-catenin localizes to dendrites and synapses, …
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