Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"developmental genes"”.
-
Quantitative Real-Time PCR Analysis of Colchicine Pathway and Rhizome Developmental Genes
… of G. superba sequences have identified putative genes potentially involved in the colchicine biosynthesis pathway and rhizome development, respectively. Using quantitative real-time polymerase chain reaction (qRT-PCR), a comparative analysis of gene expression in G. superba may reveal …
-
Characterization of the Key Mouse Cochlear Developmental Genes for Auditory Hair Cell Regeneration
… signaling in the mouse inner ear at different developmental stages, and found that the ability of Notch signaling in generating new HCs declines after birth. Last, we achieved reprogramming of neonatal and juvenile, but not adult, SCs into HCs, through ectopically expressing Atoh1 in SCs. Taken …
-
The Role of Arabidopsis thaliana Clade A1 Heat Shock Transcription Factors in Growth and Development
… HSFA1b, in Arabidopsis was shown to have altered developmental traits as well as increased stress and disease tolerance. In this study, plants overexpressing HSFA1b had smaller rosettes in seedlings and mature plants, longer inflorescence and early flowering. A number of candidate developmental …
-
Genetic Profiling in Soft Tissue Sarcoma
… (SS). The differential expression of various developmental genes, transcription factors, histones, and metallothioneins suggests that the gene fusion variants have distinct downstream effects. In Study III, 177 STS of mixed histopathological subtypes were profiled using cDNA microarrays. …
-
The Effect of impaired Cyclooxygenase 2 activity on gene regulation in the developing mouse brain and the role of PGE2 in oxidative stress production in Differentiated Neuronal Cells
… analysis to identify differentially expressed genes among males and females at embryonic day 16 (E16) and 19 (E19). Bioinformatics software outlined genes involved in mitochondrial function, inflammatory responses, and synaptic plasticity. In study 2, differentiated Neuroectodermal (NE-4C) stem …
-
Analysis of CHD Remodelers during Development: A Tale in Two Organisms
… organisms requires the precise timing of genes important for development transitions. Organisms have recruited ATP-dependent chromatin remodelers to ensure the correct timing of gene expression during developmental transitions. Here I show how different CHD ATP-dependent chromatin …
-
Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
… specifically being a key player in the pathogenesis of IPF. Recent studies have shown that recapitulation of developmental genes in AT2 cells is associated with the abnormal epithelial phenotype seen in IPF, however the specific genes and<em> </em>the mechanisms of how they alter epithelial …
-
THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
… and define cell identity during embryogenesis. To maintain cell identity and genome integrity, epigenetic marks are faithfully inherited during DNA replication through tightly coordinated processes. Our recent work demonstrated that disruption of DNA replication, known as replication …
-
Danio rerio (Hamilton, 1822) širdies ir kraujagyslių sistemos vystymosi ir regeneracinių mechanizmų tyrimai /
… and regeneration. However, conditional mutagenesis, which is essential for dissecting a role of developmental genes in regeneration, has not been demonstrated in the adult zebrafish. This remains a main disadvantage of D. rerio model system. The main aim of this research project was to use …
-
Studying the mechanisms of cardiovascular development and regeneration in Danio rerio (Hamilton, 1822) /
… and regeneration. However, conditional mutagenesis, which is essential for dissecting a role of developmental genes in regeneration, has not been demonstrated in the adult zebrafish. This remains a main disadvantage of D. rerio model system. The main aim of this research project was to use …
-
Comparative analysis of gene expression in two sexually dimorphic crustacean species Euphilomedes carcharodonta and Euphilomedes morini
… and by studying expression levels of selected developmental genes at instar IV, V adult stages and embryos, the underlying expression pattern change that leads to phenotypic differences can be seen. By comparing the differences in expression between two sarseilloid species, Euphilomedes …
-
Nla28 Activator Modulates σ54-dependent Gene Regulation in Myxococcus xanthus
… it a model organism for studying multicellular developmental processes in bacteria. In response to environmental changes, M. xanthus cells collectively and dramatically adjust their morphology, physiological functions, and biosynthesis. Particularly, M. xanthus copes with starvation by producing …
-
Gene duplication and the evolution of the higher diptera
… (honey bee) at three scales: eye-specific genes, developmental genes, and genome-wide. All three studies consistently show that the <i>Drosophila</i> genome contains an exceptionally high number of lineage-specific yet ancient gene duplicates, the majority of which must have originated …
-
TOWARD STRUCTURAL INSIGHTS INTO THE RECOGNITION OF H3K27 TRIMETHYLATION BY CANONICAL PRC1
… epigenetically regulate the transcription of key developmental genes involved in embryogenesis, pluripotency and tumorigenesis. Alterations in their activity are hallmarks in developmental disorders and cancer as chromatin modifiers are one of the most frequently mutated groups of genes in human …
-
WHO: A Novel Wuschel-Like Homeodomain Transcription Factor in Arabidopsis
… analysis and RT-PCR data indicated ∼280 genes were upregulated in the overexpression mutant who, including pivotal developmental genes such as HISTONE H1, CUP-SHAPED COTYLEDON1 (CUC1), CLAVATA3 (CLV3 ) and SHOOTMERISTEMLESS (STM). Taken together, these findings indicate that the …
-
Role of androgens in testicular development and dysgenesis
… are hypothesized to comprise a testicular dysgenesis syndrome (TDS). TDS arises when maldevelopment (dysgenesis) of the fetal testis results in hormonal malfunctions and abnormal development and function of the somatic cells. It is thought that the suppressed intratesticular testosterone …
-
EPIGENETIC MECHANISMS OF POLYCOMB REPRESSIVE COMPLEX 1 IN INTESTINAL LINEAGE COMMITMENT
… essential for the transcriptional repression of developmental genes, such as germ-line related genes in embryonic stem cells (ESCs) (3). During intestinal homeostasis, chromatin modifiers play important roles in maintaining transcriptional signatures of specific cell types. Our group has already …
-
Unraveling the role of the antifungal peptide AnAFP in Aspergillus niger through a systems biology perspective
… pattern correlates with the activation of genes associated with autophagy, nutrient recycling, and development. Consequently, it has been suggested that AnAFP may operate as a cannibalistic toxin, promoting programmed cell death and contributing to the progression of development, ultimately …
-
Targeting Unique Domains of Lsd1 Regulates Pediatric Glioma Innate Immunity and Nk Cell Metabolism
… hijack these epigenetic pathways, reactivating developmental genes to drive growth and deactivating tumor suppressor and immune recognition genes. Chromatin-modifying proteins deposit and remove chemical moieties from histone tails to aid in governing gene expression, and these proteins have …
-
In silico approaches to investigating mechanisms of gene regulation
… the precise spatial and temporal expression of genes is critical to our understanding of gene regulatory networks. Connecting transcription factors to the cis-regulatory elements that they bind and regulate remains a challenging problem in computational biology. The rapid accumulation of whole …
Page 1 of 2