Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"developmental exposure"”.
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Effects of Developmental Exposure to Environmental Contaminants on the Auditory System
… consumption of contaminated fish and seafood. Developmental exposure to these contaminants can result in a variety of neurotoxic effects, including long-term auditory deficits. We assessed auditory function in adult rats developmentally exposed to a unique PCB mixture formulated to model the …
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Developmental exposure to an environmentally relevant phthalate mixture impacts ovarian health in mice
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Developmental Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Induced and Exacerbated Autoimmunity in Adulthood
Developmental 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure can permanently alter immune system ontogeny, resulting in the dysregulation of a number of vital immune pathways. We hypothesized that developmental exposure to TCDD may also impair the establishment of self-tolerance, resulting in …
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Assessing the impact of domoic acid exposure on the zebrafish (Danio rerio) brain across life stages
… prevent acute toxicity from high-level exposure, low-level exposure can still have effects on brain development and function. Developmental stages are particularly sensitive to low-level exposure. This thesis assesses the impact of DA exposure on brain health in both development and …
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p,p' DDE Regulated Gene Expression and Possible Mechanisms of Action in Breast Tumor
… in MMTV-neu mice determined that localized, developmental exposure to the reported anti-androgen p,p' DDE accelerated mammary tumor development. This study tested the potential cancer-promoting actions of p,p' DDE, the most prevalent and persistent DDT metabolite. </p><p> Objectives: To …
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Characterizing the Developmental and Reproductive Toxicities of Cannabidiol and Δ9-Tetrahydrocannabinol
… and multigenerational toxicities following a developmental F0 exposure to 0.024–5 mg/L (0.08–16 µM) THC or 0.006–1.2 mg/L (0.02–4 µM) CBD. In this study, THC was used as a positive control due to its established developmental toxicities. An additional goal of this project was to analytically …
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Pesticides and Pesticide Mixtures Induce Neurotoxicity: Potentiation of Apoptosis and Oxidative Stress
… to develop postnatally, we hypothesized that developmental exposure to endosulfan or zineb alone or in combination would result in alteration of nigrostrial neurotransmitters and would render the nigrostrial dopamine system more susceptible to chemical challenge later in life. The objectives …
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Comparison of polychlorinated biphenyl profiles in rat, fish and human tissues; the effects of consuming Great Lakes fish
… in PCB congeners were seen after 45 and 90 day exposure to the same diets, these differences are most likely due to an increased enzyme activity after the longer period of exposure, or alternatively may be due to differences between the sexes. No statistically significant differences regarding …
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Effects of developmental PCB exposure on audiogenic and amygdala kindling models of seizure
… offspring. Previously we have observed that developmental exposure to PCBs results in increased susceptibility to audiogenic seizures (AGS) in 12 month old rats that had previously been exposed to a noise induced hearing loss paradigm. Here, studies were conducted to assess the susceptibility …
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Assessing the effects of adolescent PCB exposure on executive functions in humans and animals
… in animal models and humans suggests that early developmental exposure to polychlorinated biphenyls (PCBs), a class of persistent organic pollutants, leads to deficits in cognitive functions such as cognitive flexibility and inhibitory control. These cognitive processes are mediated to a large …
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Estradiol exerts activational and organizational control over the expression of daily and circadian activity rhythms in mice
… 2). Second, I will examine the impact of developmental estradiol on adult daily and circadian activity rhythms during a neonatal critical period associated with maturation of the suprachiasmatic nucleus (SCN), a hypothalamic structure regarded as the ‘master oscillator’ (Chapter 3). …
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Intergenerational and Transgenerational Effects of Endocrine Insults
… effects that persist in the absence of any exposure (either directly or of parental germ cells) to the triggering environment. Numerous reports of non-genetic inheritance ascribe it to epigenetic mechanisms, but behavioural, microbiotic, cultural, and/or ecological factors more likely play a …
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Effects of PCBs and PBDEs on response inhibition and dopaminergic signaling
… that share physical and neurotoxic properties. Developmental PCB exposure has been associated with impulsive behavior in laboratory species and human cohorts, while little is known about whether PBDEs have similar effects. Both PCBs and PBDEs have been shown to perturb dopaminergic …
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Later Life Consequences of Subteratogenic Exposure to a Complex PAH Mixture in the Atlantic Killifish (Fundulus heteroclitus)
<p>Subteratogenic and other low-level chronic exposures to toxicant mixtures are an understudied threat to environmental and human health. It is especially important to understand the effects of these exposures for contaminants, such as polycyclic aromatic hydrocarbons (PAHs) a large group of more …