Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 97 for “"developmental disorders"”.
-
Memory consolidation in developmental disorders
… and math seem to be a relative weakness in neurodevelopmental disorders; repeated learning trials may be needed to allow diagnosis-specific deficits to emerge; cognitive variables predict academic, but not social functioning; consolidation could be treated as a separate, emergent variable and …
-
Functional genomics of developmental disorders
… as a diagnostic biomarker for children with rare developmental disorders in chromatin-modifying genes. I show that DNA methylation signatures are a general property of these genes, that they have substantial clinical and diagnostic utility, and that they can be used to resolve variants of …
-
Common genetic variation and spliceosome variants in rare developmental disorders
Although thousands of rare disorders are caused by single, deleterious, protein- coding variants, evidence suggests that common variants also contribute to risk for rare, neurodevelopmental disorders (NDDs). These are likely affecting the penetrance of protein-coding variants as well as …
-
Test-Retest Reliability and Internal Consistency of Childhood Measures of Psychological Development in Adolescents with Developmental Disorders
<p>Introduction: Neurodevelopmental disabilities have been increasing over time, therefore there is an amplified need for psychometrically sound measures of psychosocial well-being to assist in proper diagnosis and treatment planning. This study aimed to evaluate the test-retest reliability and …
-
Improving Care Coordination for Children with Autism Spectrum Disorders and Developmental Disorders/Delay/Disabilities in the United States
… and high-cost children with Autism Spectrum Disorders (ASD) and DD (Developmental Disorders/Disabilities) using two large national databases. we also examined PCMH utilization across both ASD/DD and MBD. The specific questions posed in this dissertation provide insights into status of current …
-
Mechanical design of PlayLamp : a minimally intrusive device for recording the behavior of children at-risk of developmental disorders
… the development of children at-risk of having developmental disorders in development at MIT's Media Lab Cognitive Machines Group. The physical form of PlayLamp is intended to be non-intrusive and have easy non-destructive installation while being aesthetically appealing and respectful of …
-
Overlapping phenotypes - a clinical and magnetic resonance imaging investigation of schizotypy and pervasive developmental disorders in adolescents with cognitive impairment
… The neurobiological bases of pervasive developmental disorders (PDD) and schizotypy are not well established. In addition there are clinical overlaps between the two which can make diagnostic determination difficult. The primary aim of this thesis was to explore the relationship between …
-
Childhood behavioral and developmental disorders : association with maternal alcohol consumption and use of health services in Cape Town, South Africa
… birth defects known as Fetal Alcohol Spectrum Disorders (FASD). Fetal Alcohol Syndrome (FAS), which detrimentally affects the neurodevelopmental, physical, and social capabilities of children, is the most severe diagnosis on this scale of disorders. Research suggests that FASD rates exceed FAS …
-
Case-control study of the association of use of health services by children with behavioural and developmental disorders with prenatal alcohol exposure
… birth defects known as Fetal Alcohol Spectrum Disorders (FASD). Fetal Alcohol Syndrome (FAS), which detrimentally affects the neurodevelopmental, physical, and social capabilities of children, is the most severe diagnosis on this scale of disorders. Research suggests that FASD rates exceed FAS …
-
Word learning from object, speaker and environmental cues in typically developing children, children with autism spectrum disorder and children with other developmental disorders.
… developing (TD) children and children with other developmental disorders (DD) were also included. In order to tease apart whether word learning is delayed or deviant in ASD and if this extends to DD children, each study recruited participants with a wide range of receptive language abilities. The …
-
The Effect of Total Communication on the Language and Social Behaviors of an Autistic Child: A Case Study.
… is, in fact, one of the most devastating of the developmental disorders.
-
Germline mutation in rare disease
… and the contribution of these mutations to rare developmental disorders. These sources of variation encompass types of mutations that have been previously underrepresented in genetic research as well as individual mutation rates and spectra across individuals and parental origin. These analyses …
-
Genetic interactors of the SWI/SNF chromatin remodelling complex in Caenorhabditis elegans
… SWI/SNF complexes cause a multitude of different developmental disorders including Coffin-Siris syndrome, Nicolaides-Baraitser syn- drome, and autism. However, the molecular mechanism(s) by which mutations in SWI/SNF cause developmental disorders remain unclear and there are currently no …
-
Pathogenicity and selective constraint in the non-coding genome
… variation in regulatory elements to Mendelian disorders and attempted to approach this problem from three different perspectives. I first sought to assess the contribution of regulatory variation to severe developmental disorders using sequence data from 8,000 affected individuals and their …
-
Common genetic variants contribute to risk of rare severe neurodevelopmental disorders
Most known genetic causes of severe childhood developmental disorders are rare, deleterious, protein-coding changes that cause Mendelian disorders. Children with these disorders typically show early-onset impairment in growth, learning and adaptive behaviours. Linkage and whole exome sequencing …
-
Essays on the Long-term Effects of Childhood Chronic Conditions
… chronic conditions (e.g., physical, mental/developmental) on health and socioeconomic outcomes in young adulthood. Across three studies, I address issues pertaining to underlying mechanisms, sources of heterogeneity, and comparatively examine the effects of different conditions. I draw on …
-
The relationship between healthcare services and financial burden among families of children with autism spectrum disorders: A US perspective
… higher financial burden as compared to other developmental disorders. The financial burden was significantly associated with various facets of healthcare provision</p> <p>CONCLUSIONS: The findings highlight the role of coordinated care, access to care, and quality of healthcare interactions in …
-
Shp2 Regulates Vascular Endothelial Matrix Degradation in Phosphatase-Independent Manner
… that is implicated in many diseases such as developmental disorders and cancers. One of its suggested physiological functions is regulation of angiogenesis, which is often impacted in Shp2 pathologies. However, its role in angiogenesis is still poorly understood. In our work, we show that …
-
The Localization of β-catenin During Xenopus Kidney Development: A Look into β-catenin's Role in Kidney Development
… development. Wnt pathways regulate a variety of developmental processes, including cell migration, proliferation, and fate determination. Dysregulation of Wnt signaling can lead to developmental disorders and diseases. The primary Wnt trajectory: canonical signaling regulates transcription …
-
Aggressive behavior in adolescents with fetal alcohol spectrum disorders
Behavioral studies of fetal alcohol spectrum disorders (FASD) have indicated that aggression is common amongst alcohol-exposed adolescents, and that it appears to become more prevalent with age in that population. Such studies have documented the presence of aggression as a behavioral outcome, but …
Page 1 of 5