Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 108 for “"developing brain"”.
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Quantitative spatial transcriptomics of the developing brain
… are lacking. Applying this capability to the developing brain would enable reconstruction of a full spatial transcriptomic map of neural heterogeneity and the discovery of novel regional neural subtypes with potential functional implications. Such capability would ultimately culminate in the …
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Diffuse Optical Tomography Methods for Imaging the Developing Brain
… to perform early and continuous monitoring of brain function in infants. Its methodology overcomes many of the technical and logistical challenges of performing magnetic resonance imaging (MRI) investigations in neonates. However, standard DOI systems suffer from limitations such as low spatial …
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Growing Up POMC: Pro-opiomelanocortin in the Developing Brain
… of Pomc- and Npy-expressing neurons in the developing mediobasal hypothalamus (Chapter 2). These experiments led to the unexpected finding that during mid-gestation, Pomc is broadly expressed in the majority of newly-born ARH neurons, but is subsequently down-regulated during later stages of …
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Molecular and Neurochemical Effects of Methylphenidate on the Developing Brain
… pathways. The investigations were conducted on brain regions implicated in the symptoms of ADHD in adolescent rats. Our data shows in Chapter 3 that MPH increases whole tissue and extracellular dopamine levels in the frontal cortex and striatum. Interestingly, this effect was more prominent in …
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Developing brain and systemic inflammation: a "Toll-like" link with consequences
The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. Hypoxia/ischemia (HI), infections and inflammation are implicated in the …
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Effects of Transcranial Direct-Current Stimulation on Motor Learning in the Developing Brain
… stimulation (tDCS) is a form of non-invasive brain stimulation applied in both healthy and clinical populations. Application of weak current induces electric fields at the neuronal level, and may lead to behavioral effects such as enhanced motor learning when paired with training. Nearly all …
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The Effects of Youth Football on the Developing Brain: A Multi-Modal Neuroimaging Study
… season without sustaining a mild traumatic brain injury (mTBI). There is a growing concern regarding the association between later-life neurodegenerative disease development and earlier life head injury. This association is linked to the combination of recurrent mTBI and repetitive …
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Magnetic resonance imaging and surface-based analysis techniques to quantify growth of the developing brain
Human brains, and those of most higher mammals, are gyrencephalic: folded) to accommodate a large cortical surface within the limited volume of the skull. Abnormal folding of the cerebral cortex in humans is associated with a number of neurological dysfunctions and diseases such as schizophrenia …
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Does one plus one make two? Investigation of pharmacological effects and cortical injury on the developing brain
… and cortical injury during development affects brain plasticity. Rats were given either a low dose of perinatal fluoxetine or a mild postnatal day 7 Hypoxic‐Ischemic (HI) injury, both, or neither. The functional outcome was assessed using a series of behavioral tasks and anatomical measures. To …
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The Nrg Growth Factors and Their Receptor ErbB4 in the Developing Brain: Delineation of Nrg3 Expression and Neuritogenesis
The developing brain is a highly dynamic structure, making it repeatedly vulnerable to possible developmental abnormalities that can endure into adulthood. The neuregulin (Nrg) family of growth factors (Nrg1-4) and their receptor, ErbB4, have been linked to mental illnesses considered to emerge as …
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The longitudinal effects of HIV and ART on the developing brain: a structural MRI study using manual segmentation
… populations receiving treatment has reported brain abnormalities across a variety of ages and modalities. There are limited longitudinal studies, which would clarify if the observed changes represented developmental delay or ongoing damage. In addition, most neuroimaging studies do not include …
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Normative Range Parenting and the Developing Brain: Investigating the Functional and Structural Neural Correlates of Parenting in the Absence of Trauma
… insight into the effects of early adversity on brain development and risk for psychopathology. However, much remains unknown about the impact of normative range variation in parenting on these same processes. The primary aim of this dissertation is to begin to address this gap in the literature. …
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Characterization of brain response following cranial radiotherapy
… a vital component for the treatment of pediatric brain tumors, with combination therapy that includes CRT resulting in almost 90\% five-year survival. However, survivors treated with CRT exhibit alterations in brain development and long-term deficits in brain structure and function. Clinical and …
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Regulation of mammalian neuronal circuit development by CPG 15
… it to play a central role in the wiring of developing brain circuits. Here we utilize a mouse mutant, which is null for the cpg15 gene (cpg15 KO), to elucidate the mechanism of CPG15 function in the developing brain. Analysis of the cpg15 KO mouse suggests that CPG15 signaling leads to the …
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Examination of Molecular Mechanisms Underlying Developmental and Adult Learning-Associated Plasticity in the Rat Brain
… proteins (Fos-related proteins) in the rat brain during development when cell differentiation is prevalent using immunocytochemistry with a Fos-specific and a Fos and Fos related protein-specific antibody. Results of the study showed that Fos and Fos-related antigens are differentially …
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Prophylactic Cranial Irradiation Reduces The Incidence of Brain Metastasis In A Mouse Model of Metastatic Breast Cancer
… irradiation (PCI) is a preventative whole-brain irradiation technique used to reduce the incidence of brain metastasis and improve overall survival in select patients with small cell lung cancer and acute lymphoblastic leukemia. A population of breast cancer patients – stage IV, HER2+ or …
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