Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"deuterium metabolic imaging"”.
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Investigation of metabolism in glioblastoma patient-derived xenografts using deuterium metabolic imaging
The identification of metabolic subtypes of cancer could be used to indicate prognosis and sensitivity to treatment. Conventional anatomical imaging techniques provide morphological information, such as tumour size and perfusion. However, they do not provide any information on metabolic activity, …
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Carbon and Deuterium MRI studies of human brain metabolism
Metabolic changes to the brain can be due to brain disease causing impaired functioning. Imaging of the metabolic processes is an emerging area of research that can allow for greater understanding of the brain disease whilst offering clinical potential for improved diagnosis. Hyperpolarized (HP) …
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Development of Magnetic Resonance Spectroscopic Imaging Methods to Assess Tumour Metabolism
… proposed as magnetic resonance spectroscopic imaging (MRSI) agents for investigating metabolism, perfusion and pH in tumours. However, the sensitivity of direct detection is limited by the low gyromagnetic ratios of these nuclei. Sensitivity can be increased by transferring the …
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Development of imaging techniques to assess tumour cell death
Cell death is an important imaging target for assessing early tumour treatment response and the effectiveness of therapy. Traditionally, anatomical imaging modalities measure changes in tumour size (Response Evaluation Criteria in Solid Tumours (RECIST)). More recently these assessments have also …
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Potential of metabolic MRI to address unmet clinical needs in localised renal cancer.
… identify the unmet needs, and propose how metabolic imaging techniques could be used to tackle these needs. This proposal was the core of my PhD research, of which results I present in Chapters 2-4, as described below. 1. Chapter 2: here I investigated the potential of hyperpolarised …