Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"desmin"”.
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GFP- coated microparticles to quantify and compare wild- type desmin with known desmin mutations in human heart disease via quantitative live-cell fluorescence Imaging
… to direct quantification the abundance of desmin protein in wild-type and three DES missense mutants variants known as DES-p.Ala120Asp (p.A120D), DES-p.Leu136Pro (p.L136P), and DES-p.Asp312Ala (p.D312A), desmin is an essential protein of the intermediate filaments in myocytes, and its …
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Fiber Type-specific Desmin Content in Human Single Muscle Fibers
… content of the intermediate filament protein, desmin, between type I and type IIa single muscle fibers from a mixed muscle in human subjects. Biopsies were taken from the vastus lateralis of six recreationally active males. Approximately 150 single muscle fibers were dissected from each sample …
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Evaluation of rapid evaporative ionization mass spectrometry (REIMS) for the prediction of slice shear force and biochemical markers of tenderness in beef Longissimus lumborum steaks
… length, myofibril fragmentation index (MFI), desmin, and troponin-T degradation. Thirteen machine learning algorithms were used to build several predictive models. Data were reduced using feature selection (FS) and principal component analysis followed by FS (PCA-FS). No models could predict …
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First evidence of skelemin, a myosin-associated protein, in smooth muscle and its involvement in cell adhesion, and, The role of the cell cycle in cell type choice during mammalian development
… for skelemin, smooth muscle myosin, and desmin. I observed that skelemin antibodies colocalized with the myosin-II filaments as well as the desmin intermediate filament cytoskeleton. This is the first evidence of a myosin-associated protein within smooth muscle, and it raises the …
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Studies of atrial natriuretic peptide in the freshwater turtle Pseudemys scripta
… to the muscle protein fragments porcine desmin protein and human cardiac $\alpha$-myosin protein.
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IMMUNOPROFILE IN EFFUSION CYTOLOGY
… CK 5/6 and HBME‐1 as mesothelial cell markers; desmin as mesothelial cell malignancy marker; and CK7/CK20 as a marker of metastasis. Malignancy was confirmed by histologic evaluation; non‐malignant conditions were confirmed by follow‐up. Sensitivities, specificities and predictive values were …
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Behaviour of human myoblasts in vitro: role of ageing and inflammatory cytokines
… Markers of proliferating muscle cells were desmin, NCAM and Ki67, and markers of differentiating muscle cells were myogenin and myosin heavy chain. Additional parameters observed were DNA damage and analysis of specific cytokines in the cell secretome. No differences in any parameter …
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Cardiomyocyte Autophagy Is Induced by Protein Aggregation in Heart Disease
… I turned my attention to CryABR120G-induced desmin-related cardiomyopathy (DRCM), an aggregate-associated disease with autosomal dominant inheritance. My studies demonstrated that 1) autophagy is activated by CryABR120G-induced protein aggregation, 2) aggregate formation is inversely …
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PATHOLOGY OF THE UROGENITAL TRACT IN DOMESTIC ANIMALS
… α-smooth muscle actin, smooth muscle myosin and desmin. Histopathological features as well as the immunohistochemical results, positive for vimentin, actin, myosin and desmin, confirmed the mesenchymal origin and the myoid phenotype of both testicular tumours supporting the diagnoses of …
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Postmortem energy metabolisms' role in calpain activation, inhibition, and subsequent function
… served as substrates to monitor degradation of desmin and troponin-T, two surrogates of muscle proteolysis postmortem. Minimal proteolysis occurred with early postmortem samples (0 and 1 d), while proteolytic activity increased notably by day 2 in LTL. ER samples exhibited limited proteolysis …
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Type-5 Phosphodiesterase Inhibition in the Prevention of Doxorubicin Cardiomyopathy
… labeling and in situ oligo ligation methods. Desmin distribution was determined via immunofluorescence. Bcl-2 was analyzed by Western blot. Left ventricular function was measured in Langendorff mode. Electrocardiographical analysis measured changes indicative of doxorubicin cardiotoxicity …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… epithelia acquire fibrotic biomarkers such as desmin, S100A4 and α-smooth muscle actin. In lung fibrosis this has not been characterised, further the molecular mechanisms in the lung are poorly understood. Identifying these processes is key to developing improved future therapeutic …
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Localization of Cytoskeletal Elements in Teleost Retinal Pigment Epithelium
… of its co-localization and co-isolation with desmin. Through biochemical analysis, the G.3.5 antigen was found to contain a peptide sequence that is 80% homologous to the actin binding region of human sarcomeric a-actinin. Recent Studies have suggested that the G.3.5 antigen may be a novel …
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Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription
… BMCs differentiated into NG2 and desmin positive pericytes <em>in vitro</em>. In contrast, inhibiting SDF-1α and PDGF-B abolished this differentiation process. <em>In vivo</em>, we injected TC71 or A4573 tumor-bearing mice with the SDF-1α antagonist, AMD3100 and found that …
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Quantitative analysis of subcellular biomechanics and mechanotransduction
… an αB-Crystallin mutation (R120G) that causes desmin-related myopathy. These studies showed impaired passive cytoskeletal mechanics in adult mouse cardiac myocytes. Finally, we studied cells deficient in the nuclear envelope
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Immunhistochemische Charakterisierung von neugebildeten Geweben im Bereich von interventionell eingesetzten Okkludern für den Verschluss von angeborenen Septumdefekten des Herzens
… muscle actin, smooth muscel myosin, h-caldesmon, desmin) identifiziert werden. Im neuformierten Gewebe fanden sich typische immunhistochemische Muster für kleine Gefäße und Kapillare. Inflammatorische Zellen wurden als Makrophagen (CD 68+) sowie als B- und T-Lymphozyten (CD3+ und CD79+) …
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Produktion und molekulare Charakterisierung eines monoklonalen polyreaktiven, 'natürlichen' Autoantikörpers
… Subpopulation von Maus-B-Zellen, Cytokeratin, Desmin, Fibronectin, g-Fc, hCI, hCII, hCIV, hCV, hsp65, Hu-Alb, Insulin, mCII, Ov-Alb, Pepsin, Rattenmyosin, Somiten im Mausembryo, Tg, TPO, TSH-Rezeptor, Vimentin, Z-Ag. Sie erkennen nicht HEp2 Zellen und Gelatine. Die kappa-Kette des Klons G1.B6 …
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The effects of gene replacement therapy on respiratory and gait function in a canine model of X-linked myotubular myopathy
… length canine MTM1 cDNA under a muscle-specific desmin promoter by three different routes of administration—local intramuscular injection of the hindlimb, isolated perfusion of the hindlimb and systemically. Systemic treatment was carried out at three different doses to determine the minimum …
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Molekulare Bindungsstudien herzmuskelspezifischer Protein-Varianten mittels Rasterkraftspektroskopie (AFM)
… stehen, darunter gehören die Gene für Desmin und das Transmembranprotein 43 (TMEM43). In dieser Dissertation wurden die desmosomalen, wildtypischen Protein-Isoformen *Desmoglein-2*, *Desmocollin-2* sowie die Desmoglein-2-Variante *p.R46Q* und die Desmocollin-2-Varianten *p.D350Y* und …
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Development of Quantitative Tools for the Characterization and Analysis of the Blood Brain Barrier in Normal and MPS IIIB Mice
… cells, and no changes in the contact area of desmin positive pericytes with endothelial cells.<strong></strong></p>
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