Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"designer receptors exclusively activated by designer drugs"”.
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Abnormal cortical activity leads to misallocation of GABAergic interneurons in the mouse neonatal brain.
… hyödyntämällä erilaisia yhdisteitä sekä Designer Receptors Exclusively Activated by Designer Drugs (DREADD) -teknologiaa. Solulaskenta unilateraalisen sensorisen deprivaation jälkeen paljasti GAD67-positiivisten hermosolujen epätavallisen allokaation korteksin syvimpiin kerroksiin …
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The External Globus Pallidus: Bidirectional Control Over Anxiety-Related Behavior Mediated By Crfr1
… CONTROL OVER ANXIETY-RELATED BEHAVIOR MEDIATED BY CRFR1</p> <p>Albert Lee Joseph Hunt, Jr., B.S.</p> <p>Advisory Professor: Shane Cunha, Ph.D.</p> <p>Corticotropin-releasing factor receptor 1 (CRFR1), the principle receptor responsible for the anxiogenic activity of the stress peptide CRF, is …
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have gained popularity as a tool to investigate the neural substrates of behaviour in rodents. When used with spontaneous behavioural tests of memory in rodents, DREADDs allow for a unique opportunity to advance our understanding …
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Oligodendrocyte precursor cell states and their regulation
… voltage-gated ion channels and neurotransmitter receptors. Functional expression of these channels and receptors is often described as a defining feature of OPCs, although several reports suggest that OPCs exhibit diversity in their electrophysiological properties. In this thesis, I investigate …
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Investigation of Glutamatergic Circuitry Underlying Copulatory Reward in Female Syrian Hamsters
… NAc during female sexual behavior, I employed designer receptors exclusively activated by designer drugs (DREADDs) to selectively inhibit these excitatory mPFC efferents. I demonstrated that this selective inhibition decreases sex-induced activation of the NAc, confirming the importance of the …
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The Role of Neuronal Activity in Adult Myelin Plasticity
… plasticity during adulthood was investigated. Designer receptors exclusively activated by designer drugs were used to alter the activity of neurons bidirectionally to observe the activity dependence of myelin. Long-term neuronal activity changes were applied to the optic nerve, a tract in the …
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… neurons unveiled an interesting mechanism by which type 2 cytokines can affect NMU-ergic neuronal regulation of ILC2 and Th2 cell responses across different mucosal sites during infection with *N. brasiliensis*. Furthermore, flow cytometric analysis of lymphocyte populations following *Il7* …
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Characterising hippocampal replay in the APP<sup>NL-G-F</sup> mouse model of Alzheimer’s disease
… in Alzheimer’s disease; a disorder characterized by progressive memory dysfunction. It is therefore pertinent to understand how functional changes in the hippocampus, including those related to replay, relate to the pathological and symptomatic changes that accumulate of the course of the disease. …
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Marmoset emotional regulation during adolescence and adulthood, with a particular focus on risk-taking and the role of the subgenual anterior cingulate cortex in motivation and affective biases
… period during animal development, characterised bywidespread neural and behavioural changes, including increases in exploratory behaviour and risk-taking. These behavioural and neurobiological changes are particularly evident in primates, where social groups and relationships are complex, and …
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An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding
… (KO) showed that some of this increase is driven by taste receptor input, but this effect is predominantly for quinine hydrochloride (QHCl). On the other hand, increases in FLI to sucrose (relative to water) in the lateral PBN were the same for both B6 and KO mice, leading to the conclusion that …
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
… of maladaptive behaviors characterized by the uncontrolled use of a rewarding substance. These include substance use disorders, binge eating disorder, certain subtypes of obesity, gambling disorder, and internet gaming disorder. Each of these disorders share similar behavioral …