Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"designed peptides"”.
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Analyzing Functional Interactions of Designed Peptides by NMR Spectroscopy
… report the analysis of two groups of synthetic peptides designed for two applications – broad bactericidal action and inhibition of protein-protein interactions in human cells. Novel amphiphilic peptides designed for antibacterial application incorporated arginine as cationic amino acids and …
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Enzyme responsive nanomaterials for cancer applications
… influence cancer cells. Peptide amphiphiles were designed (PhAc-FFAGLDD (1a) and GFFLGLDD (2a) and their expected products of enzyme cleavage PhAc-FFAG (1b) and GFFLG (2b)) such that, upon cleavage by a disease-associated enzyme, reconfigure from micellar aggregates to fibres. After the designed …
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Towards incorporation of catalytic function into small folded peptide scaffolds
… the active thiazolium species. A series of designed peptides containing the Taz coenzyme chimera revealed that an increasingly structured and hydrophobic peptidyl environment can dramatically enhance the acidity of the thiazolium C2 methine, the initial step in the catalytic pathway. A …
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Towards rational design of peptides for selective interaction with inorganic materials
… screen with yeast displayed rationally designed peptides was performed on a panel of II-VI semiconductors and gold. Cell binding results indicated that peptide interaction was mediated by a limited number of amino acids that were influenced by locally situated residues. Interpretation of …
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A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
… beta4 interaction with 12-LOX using specifically designed peptides recapitulated the 12-LOX knockdown phenotype. Additionally, inhibition of 12-LOX led to decreased HGF-induced invasion. This is the first demonstration that 12-LOX may have a novel function in modulating c-MET and beta4 signaling …
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Uncovering molecular orientation and morphology at biotic/abiotic interface for peptide-based graphene sensors
… (AFM). The results showed that almost all designed peptides tend to adopt an overall parallel orientation on the graphene surface, and the presence of aromatic residues reduces peptide backbone alignment. Moreover, exposure to the VOCs caused distinct changes in the peptide’s orientation …
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Interazioni tra Glicoproteine che mediano la penetrazione del Virus Herpes Simplex nella cellula e disegno razionale di Peptidi Inibitori
… of the project dealt with rational design of peptides inhibiting virus entry has been performed. Considering gB and gD, the crystal structure is known, so we designed peptides that dock in the structure or prevent the adoption of the final conformation of target molecule. Considering the other …
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
… to drug discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed into potential new PPI inhibitors. This study sets out to investigate whether this could be achieved through the grafting of binding peptides into …
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The Rational Design of Coiled-Coil Peptides towards Understanding Protein-Crystal Interactions and Amorphous-to-Crystalline Transitions
… commonly known as brushite. Coiled-coils were designed to alter the complete growth pathway of brushite beginning with an amorphous precursor and resulting in a modified crystalline state. Both the designed chemical character and the secondary structure of the coiled-coil peptides were found to …
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De Novo Design and Stabilization of β-Sheet Peptides for Biomimicry of ORR Enzymes
… folds and other tertiary arrangements. Two newly designed peptides, TZ4H and TZ4H-H3AH10D, are synthesized and characterization for these peptides feature the use of circular dichroism (CD), UV-Vis spectroscopy, isothermal titration calorimetry (ITC), electron paramagnetic resonance (EPR), …
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Toward Engineering Oxygenase Activity into the Electron Transfer Protein Azurin
… function in cysteine-containing native and designed peptides and proteins. In Chapter 3, a series of Type-2 azurin variants is reported in which the anionic redox ‘chameleon’ Cys-112 is replaced with neutral His-112 in an effort to develop a robust protein scaffold for modeling of substrate …
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Design of Peptide Ligands for 14-3-3ε, and Exploring the Role of Residue Types in Ligand Recognition by 14-3-3 Proteins
… group developed two novel, 14 amino acid residue peptides; Ac-CDC25A(173-186)-NH2 (pS), and Ac-CDC25A(502-515)-NH2 (pT), corresponding to two binding regions of CDC25A to 14-3-3 proteins. Both pS and pT bind 14-3-3ε, and induce cell death of cSCC cells, albeit at a high IC50. In the work presented …
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Modular design of coiled coils to target bZIP transcription factors
… to a partner. The first method used to design peptides that would bind tightly and specifically to bZIPs depended on the coupled binding and folding within coiled coils. In a previous study, core positions of the peptide pointing inward to the coiled-coil interface were optimized for stably and …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
… compounds, such as antimicrobial peptides (AMPs), anticancer peptides and trypsin inhibitors. Several kinds of AMPs, isolated and characterised from the skin of amphibians, have been studied by researchers to provide novel kinds of drugs and pharmacological agents for humans to …
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Design and Application of Transition Metal Complexes for Catalysis
… relate to the design and discovery of short peptides that self-assemble into supramolecular structures and/or provide good catalytic results. The second chapter details the design of a short dipeptide able to self-assemble and its application in the transition-metal asymmetric transfer …
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Delivery, design, and mechanism of antimicrobial peptides
… bacterial infections, focusing on antimicrobial peptides (AmPs). We first delivered genes inducing the toxic expression of AmPs and other lytic agents directly into bacteria using re-engineered bacteriophages. Expression of these lytic agents in lysogenic bacteriophages resulted in bactericidal …