Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 340 for “"design and synthesis"”.
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Design and Synthesis of Antimycobacterial Agents
… tepid with target-based screens of synthetic and structurally conservative compound libraries failing to produce new therapeutics. This has led to a renewed interest in utilising phenotypic screens, but rather than applying them to natural product libraries and running the risk of …
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Design and Synthesis of Novel Benzodiazepines
Bivalent drug design is an efficient strategy for increasing potency and selectivity of many drugs. We devised a strategy to prepare agonist-benzodiazepine heterodimers that could simultaneously bind to agonist and BZD sites of the GABAAR. We synthesized a benzodiazepine-MPEG model compound that …
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Design and Synthesis of Hyaluronan:RHAMM Interaction Inhibitors
… a regulator of cell migration/survival and differentiation during response-to-injury processes. The receptor for hyaluronan-mediated motility (RHAMM) binds to HA and has limited constitutive expression but is upregulated during tissue injury. Blocking HA fragment:RHAMM interactions has …
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The Design and Synthesis of Magnetic Nanocomposites
Magnetism lies at the core of modern technology and can be found in industries such as oil refining, automotive, telecommunications, personal electronics, and power generation that are integral to our day to day lives. This permeation into everyday life has been enhanced in the past several decades …
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Design and Synthesis of a Macrocyclic Phospholipid
… membrane stability; this thesis reports the design and synthesis of a synthetic membrane-spanning macrocyclic lipid to test this hypothesis. Protected glutaric anhydride reacted with 10-undecyn-1-ol to produce a glutarate monoester. Copper-mediated azide-alkyne coupling (CuAAC) using …
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Design and synthesis of potential antimicrobial agents
… primarily due to several decades of neglect and an emergence of multidrug-resitance strains (MDR) of M. tuberculosis together with the increased incidence of disseminated infections produced by other mycobacterium in AIDS patients. This has prompted the search for new antimycobacterial drugs. …
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Design and synthesis of novel factor Xa inhibitors.
Design and synthesis of novel factor Xa inhibitors.
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The design and synthesis of novel tacrine analogues
… of 9-amino-1,2,3,4-tetrahydroacridine (36), was designed a range of analogues. These compounds were synthesised using a Lewis acidmediated cyclodehydration reaction involving anthranilonitrile (150) and various 1-tetralones. 1-benzosuberones and 2-benzosuberone. Heterocyclic ketones such as …
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Design and synthesis of HIV-1 integrase inhibitors
… overall objective of this dissertation was to design and synthesize a novel series of IN inhibitors that retain the favorable characteristics of the b-DK scaffolds but are devoid of the "undruggable" properties. The design of the target molecules was established from crystal structure-based …
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Design and Synthesis of Natural and Unnatural Macrocycles
… potential in probing a broader biological space, and there are a significant number of bioactive macrocycles in nature. In addition, a macrocyclic scaffold provides interesting features, including high binding affinity and target selectivity due to the pre-organized conformation. Despite the …
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Design and synthesis for testability using architectural descriptions
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:49:51Z Item is restricted indefinitely.
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Design and synthesis of rotational analogues of estradiol
Studies have been conducted in synthesising bridged analogues of estradiol in which the ring D hydroxy group is displaced from the 17-position. The aim was to explore the possible rotational equivalence between such analogues and estr~diol. The synthetic routes investigated were based upon …
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Design and synthesis of conjugated macrocycles and polymers
The design, synthesis and characterization of conjugated macrocycles and polymers are presented in this dissertation. In particular, work involving the exploration of unusual and/or novel aromatic structures for various materials applications is described in detail, along with appropriate …
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Design and synthesis of molecular actuators and sensors
… which operates through incorporating and expelling counterions and solvent molecules to balance the charges generated by electrochemical stimuli (swelling mechanism). Although significant progress has been made, there still exists a need for developing new materials that would overcome …
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I. Design and synthesis of estrogen receptor gene switches. II. Design and synthesis of estrogen receptor ligands occupying an auxiliary binding pocket
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic target for breast cancer, hormone replacement therapy, contraception, and osteoporosis. Novel organic cores have been identified and developed as possible estrogen pharmaceuticals. The x-ray …
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Design and synthesis of mechanistic probes for polyhydroxybutyrate synthases
… probes have been synthesized in order to understand the mechanism of PHB synthases (PhaCs). The first type is oxo analogs in which the sulfur in the coenzyme A (CoA) thioester has been replaced with an oxygen atom. A series of 3-R-hydroxybutyryl oxo CoA analogs, (HB)[subscript]nOCoA (n = 1, 2 and …
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DESIGN AND SYNTHESIS OF FERROIC HYBRID ORGANIC-INORGANIC PEROVSKITES
… of diverse ferroic behaviors. However, the design principles for engineering one or multiple ferroic orders and their cross-coupling mechanism remain less understood. This thesis presents a comprehensive study on the design principles of ferroic perovskite single crystals, especially …
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The design and synthesis of novel potential antimalarial compounds
… current importance as a potential drug target, and the syntheses towards a selection of natural products and analogues relevant to the pathway. In Section A, the novel approach towards a new class of n-formyl amides is described. Furthermore, this new methodology is used to generate the imide …
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