Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"desensitisation"”.
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Regulation and desensitisation studies on the nicotinic acid receptors
… was tested by examining the regulation and desensitisation characteristics of each receptor in a heterologous expression system. Both HM74 and HM74A failed to interact with β-arrestin 2 or internalise in response to nicotinic acid. However, both receptors were phosphorylated in an …
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Client and clinician experiences of eye movement desensitisation and reprocessing (EMDR) therapy
… phenomenological experiences of eye movement desensitisation and reprocessing (EMDR) and their meaning-making regarding this therapeutic approach within the context of an adult mental health service. Interpretative Phenomenological Analysis (IPA) was employed to collect and analyse data from …
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Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
… regulator of neutrophil reverse migration is desensitisation of chemokine receptors. Previous work in our lab showed that desensitisation of Cxcr1 is required for neutrophils to stop and cluster. Combining a Cxcr1-desensitisation mutant with the photoconvertible line, I showed that receptor …
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Pharmacological characterisation of selective Y4 and dual Y2/Y4 receptor agonists: novel targets for putative anti-obesity therapies
… Furthermore, an assessment of Y4 receptor desensitisation was made by application of a subsequent addition of the native hormone, hPP. With a lysine linker at position 30 or 22, chemical modification of Obinepitide with either PEGylation or Palmitoylation resulted in prolonged reductions in …
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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… pleiotropy. There is added variation in receptor desensitisation and internalisation, with intracellular signalling and β-arrestin-mediated pathways adding spatial and temporal complexity. How this crosstalk regulates intracellular signalling was investigated at the Glucagon-Like Peptide-1 …
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Investigating the perceived effectiveness of Eye Movement Desensitisation Reprocessing (EMDR) treatment in adult survivors of childhood sexual abuse and the impact on neuropsychological, emotional and behavioural functioning and quality of life : a case series analysis
Childhood sexual abuse (CSA) is an ongoing issue (WHO, 2017) with 1 in 20children annually reported as being abused in the UK (NSPCC, 2019; Radford et al,2011). Many child survivors are of adolescent or young adult age before they requesthelp from relevant services (HAVOCA, 2021; NSPCC, 2018; Noel, …
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The Effect of Anticholinesterase Action on Mammalian Skeletal Neuromuscular Transmission
… in transmitter action, perhaps, by receptor desensitisation. The association between desensitisation and endplate calcium accumulation has been discussed,
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How do veterans make sense of their disengagement from traditional exposure therapy and their subsequent engagement in a non-exposure based therapy for Post-Traumatic Stress Disorder?
… for post-traumatic disorder (PTSD): Eye-Movement Desensitisation and Reprocessing (EMDR) and exposure based interventions. Contextual reasons for the success or failure of particular treatment models that are often only tangentially related to the theoretical underpinnings of the models are …
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Modelling Β2Ar Regulation
… internalisation; (iv) β2AR recycling; (v) β2AR desensitisation; (vi) β2AR resensitisation; (vii) PKA-mediated β2AR phosphorylation in response to a SABA; and (viii) LABA/SABA induced cAMP profile ± PDE inhibitors. The models of GRK-mediated β2AR regulation show that plasma membrane …
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A Critical re-appraisal and re-alignment of the viewing screen by means of an experimental body of fine art practice
… The result of such ubiquity is the viewer’s desensitisation towards the screens increasingly invisible objecthood. Instead, a hierarchy of viewership is formed – focus on images preceding focus on the screen structures that deliver them. This research employs an experimental body of fine art …
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A duty or a joy? An interpretive phenomenological analysis of EMDR therapists’ experience of Continuing Professional Development (CPD); and what they think they need to know
… beyond standard training. 12 Eye Movement Desensitisation and Reprocessing (EMDR) practitioners were interviewed about their training, their CPD experience and the extent to which they plan this, along with what they think practitioners need to know. Of the 12 interviewees, four were …
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An exploration of how integrative therapists working with clients presenting with complex trauma use EMDR as part of their practice: a grounded theory study
Eye Movement Desensitisation and Reprocessing (EMDR) is widely used for treating complex trauma. Although there is a large evidence base around the efficacy of EMDR, there is little practice-based research into how EMDR therapists work with clients. EMDR therapists come from a range of professional …
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Interactions of insecticidal spider peptide neurotoxins with insect voltage- and neurotransmitter-gated ion channels
… channel current decay and reversed channel desensitisation. In addition, ƙ-HXTX-Hv1c moderately increased nAChR sensitivity to nicotine. These findings are consistent with a positive allosteric modulation of insect nAChRs to slow receptor desensitisation. The nAChR is a validated …
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A critical analysis of the Working Memory model of Eye Movement Desensitization and Reprocessing
… processes in EMDR, beyond the immediate desensitisation of imagery.
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The emerging role of the a4(+)a4(-) interface as a determinant of functional signatures of a4ß2 nicotinic acetylcholine receptors
… the additional agonist site is less sensitive to desensitisation than the sites at the a4( + )/~2( -) interfaces, suggesting that the agonist sites are functionally non-equivalent. Non-functional equivalency was also indicated by the finding that the agonist selectivity of the site at the …
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Investigating the role of the CCL2/CCR2 axis in monocytes and its modulation by extracellular nucleotides
… role, P2Y6 and CCR2 engaged in crosstalk. Cross-desensitisation experiments and studies on P2RY6-knockdown THP-1 cells supported this finding and indicated that a blockade of P2Y6 signalling was likely to affect the capacity of monocytes to migrate and adhere in response to CCL2. Moreover, these …
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The Identification and Pharmacological Characterisation of Novel Apelin Receptor Agonists In Vitro and In Vivo
… These effects were achieved without receptor desensitisation, supporting the remarkable G protein bias observed in vitro. Furthermore, it was disease-modifying in vitro in an endothelial cell apoptosis assay but despite this, did not prevent pulmonary arterial hypertension in a monocrotaline …
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Computational Modelling of Fluid and Ion Transport in the Epithelial Cell
… straining beyond the range of tidal breathing. Desensitisation of purinoceptors helped prevent flooding if there were high adenosine triphosphate levels. Functional apical chloride transport was necessary for fluid secretion into the lumen. Our generic model shows that regulation of fluid transport …
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Emotion in organisations: working in British pubs
… such as emotional exhaustion, burnout and desensitisation are often referred to in the literature although relatively few researchers draw attention to any more positive effects. This project sought to widen the study of the emotional implications of service work to include the large, but …
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