Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"dermonecrotic"”.
-
Investigation of the intracellular trafficking pathways of the dermonecrotic toxin family
… define the entry and trafficking pathways of the dermonecrotic toxin family composed of related AB toxins whose members induce dermonecrosis upon injection into animal skin. The dermonecrotic toxins Pasteurella multocida toxin (PMT) from Pasteurella multocida (P. multocida), cytotoxic necrotizing …
-
Studies on the mode of action of dermonecrotic toxins: Effects on adipogenic signaling pathways and delivery of c-terminal cargo into the cytosol
The dermonecrotic toxin family consists of the dermonecrotic toxin from Bordetella spp. (DNT), the cytotoxic necrotizing factors from Escherichia coli (CNF1, CNF2 and CNF3) and Yersinia pseudotuberculosis (CNFY), and the mitogenic toxin from Pasteurella multocida (PMT). These relatively large …
-
Purification and characterization of Clostridium perfringens iota toxin
… iota b (i<sub>b</sub>), had some guinea pig dermonecrotic and mouse lethal activity. Other fractions, including the one containing the slower migrating iota a (i<sub>a</sub>) antigen, had little to no biological activity. When fractions containing i<sub>a</sub> and i<sub>b</sub> were mixed, …
-
Construction of CNFY-CNF1 Chimera Protein for Study of Differential pH Dependent Activity of CNF Proteins
… family of toxins is under the larger family of dermonecrotic AB toxins. These AB toxins have the ability to cause dermonecrosis when applied to the skin of animals. Among the dermonecrotic toxins, Pasteurella multocida toxin (PMT) and cytotoxic necrotizing factors 1, 2, and Y (CNF1, 2, and Y) …
-
Toxin-membrane interactions of Pasteurella multocida toxin and homologous domains
… of Pasteurella multocida toxin, a 144-kDa dermonecrotic AB-type toxin that causes atrophic rhinitis, and homologous domains in other toxins. We address both the N-terminal domain necessary for receptor-mediated endocytosis into the cell, as well as the intracellular membrane localization …