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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"dermatan sulfate"”.
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Structural Microheterogeneity in the Dermatan Sulfate Synthesized by Arterial Chick Embryo Fibroblasts
Made available in DSpace on 2014-12-14T04:27:40Z (GMT). No. of bitstreams: 1 7803939.pdf: 6851256 bytes, checksum: 8f38e0e41b860e83bf0d179c694238b2 (MD5) Previous issue date: 1977
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Understanding the catalytic machinery of chondroitinase ABC I in processing dermatan sulfate
… galactosaminoglycan substrates, chondroitin-6-sulfate and dermatan sulfate. Through a systematic approach, we investigate the active site of chondroitinase ABC I with biological and structural studies. We demonstrate that calcium, a divalent ion, potentially increases the activity of …
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Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development
… modulate tumor development. One of these GAGs, dermatan/chondroitin sulfate (CS/DS), is attached to proteins either bound to the cell surface or secreted in the extracellular space. CS/DS is a long linear polysaccharide consisting of alternating disaccharide units (i.e. N-acetylgalactosamine and …
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Enzymatic and analytical tools for the characterization of chondroitin sulfate and dermatan sulfate glycosaminoglycans
… important subset of GAGs, namely heparin/heparan sulfate-like glycosaminoglycans (HSGAGs). The study of chondroitin sulfate and dermatan sulfate (CS/DS), an equally important subset of GAGs, has lagged behind partially due to a lack of enzymatic and analytical tools akin to those developed for …
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FROM GENE TO STRUCTURE: Formation of Iduronic Acid in Dermatan Sulfate by Two DS-epimerases
… space. Complex polysaccharides, such as dermatan sulfate play a key role in these processes. Dermatan sulfate is a long linear polysaccharide of a repeating disaccharide unit consisting of N-acetylgalactosamine and glucuronic acid/iduronic acid. Formation of iduronic acid through …
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Enzyme Kinetics of Recombinant Human Arylsulfatase B (rhASB)
… the enzyme kinetics of recombinant human Arylsulfate sulfatase B (rhASB) by using an in vitro bioassay and direct hydrolysis substrate assay to approach the problem of substrate limitation in establishing a representative kcat for rhASB. The project also explores the makeup of a possible ASB …
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Structural and Metabolic Studies of Glycosaminoglycans (Sulfatase, Hydrazine, Mucopolysaccharidosis)
… model compounds indicated that ester and N-sulfate substituents were stable during N(,2)H(,4) treatment but that uronic acids were converted to hydrazides which were epimerized at C-5 during the hydrazinolysis reaction. Subsequently, it was found that uronic acid hydrazides could be oxidized …
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Characterization and tissue engineering of the temporomandibular joint disc
… quantities of type II collagen, chondroitin sulfate, keratan sulfate and dermatan sulfate proteoglycan compared to the anterior and posterior bands. Moreover, the intermediate zone is over an order of magnitude softer and weaker under mediolateral tension compared to these bands. Pioneering …
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Molecular therapy for mucopolysaccharidosis Type I
… of the glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate. As a result, these GAGs accumulate within lysosomes causing the development of multisystemic disease. Patients with MPS I present with clinical manifestations of disease within the first two years of life including …
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Effects of heparinoids on bovine aortic smooth muscle cells
… majority of GAG produced by SMCs is chondroitin sulfate (CS) or dermatan sulfate (DS). Most (90%) of the GAG produced by SMCs is secreted to the culture media. Heparin treatment caused a decrease in the amount of proteoglycans produced, and secreted to the culture media by log cells, while a …
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Tools for decoding the structure-function relationships of biopolymers in nanotechnology and glycobiology
… Chondroitinase ABC-II enzyme that depolymerizes dermatan sulfate and chondroitin sulfate GAGs (CSGAGs), and the 6-0- Sulfatase and N-Sulfamidase enzymes that de-sulfate functional groups on heparin and heparan sulfate GAGs (HSGAGs) are described. Second, the interaction of branched glycans with …