Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"dermaseptin"”.
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A novel dermaseptin peptide from the defensive skin secretion of Phyllomedusa camba
Hundreds of dermaseptin peptides have been isolated from the skins or the skin secre-tions of Phyllomedusa species and other related frogs and they all possess strong an-timicrobial activity with little or no haemolytic activity, which made it possible for the dermaseptin peptides to be considered …
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Identification and functional analyses of a novel dermaseptin peptide from the skin secretion of the frog, Phyllomedusa duellmani
… functions, have been studied in-depth. Dermaseptin peptides, derived from frogs of the Phyllomedusa genus, have been found to have broad-spectrum antimicrobial activities and relatively low haemolytic activities.<br/><br/>Here, one novel dermaseptin, named DS-Du, was discovered from the …
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The discovery of a novel dermaseptin identified from the defensive skin secretion of the South American frog, Phyllomedusa sauvagii
Due to the evolving drug resistance of pathogens, it is necessary to develop novel antibiotics. Through decades of investment, peptides have been proven to be one potential group of biologics that may contribute to the development of new antibiotics as they combine the advantages of both small …
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Novel bioactive peptides from the defensive skin secretion of Phyllomedusinae frogs
… massive quantities of AMPs, belonging to the dermaseptin superfamily, which exhibit remarkable antimicrobial activity against Grampositive bacteria, Gram-negative bacteria and fungi. <br/>In this thesis, we employed “shot-gun” molecular cloning and MS/MS sequencing techniques to identify novel …
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QUB-2454: a bioactive peptide from the frog skin secretion of Phyllomedusa palliate
Antimicrobial peptides belonging to the dermaseptin family are mainly found in phyllomedusine frogs. These peptides not only possess potent antimicrobial activity but exhibit low toxicity against eukaryotic cells. In a recent study, potent antimicrobial activity was correlated with the conserved …
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Identification and bio-evaluation of an antimicrobial peptide from the skin secretion of Phyllomedusa tarsius
… was deduced from the cloned cDNA encoding a dermaseptin precursor. Subsequently, this peptide was synthesised by solid-phase synthesis, and the purified synthetic form was used for biological assays. Results showed that this peptide possessed ideal inhibitory effects on S. aureus (NCTC …
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Biological activities and antidiabetic potential of novel peptides from frog secretions
… one phylloseptin peptide Phylloseptin-PBu, one dermaseptin peptide Dermaseptin-PS1 and four tigerinin peptides (Tigerinin-HR1 to Tigerinin-HR4), they exhibited distinct biological activities. <br/><br/>In Chapter 3, the detailed function and correlative mechanisms of novel phylloseptin peptide …
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Discovery, bioactivity evaluation and rational design of natural-occurring peptides from Agalychnis annae and Rana tagoi okiensis
… the truncation of the N terminus of the original dermaseptin peptide, QUB-1875, QUB-1642 and QUB-1159 were designed and synthesized. The truncation could maintain the antimicrobial activity and weaken the haemolysis. Then, analogues, QUB-1159, QUB-2132 and QUB-2683 were designed and their …
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Bioactive peptides from the defensive skin secretions of selected American and Asian frogs
… frog, Odorrana versabilis, respectively. A novel dermaseptin peptide, named dermaseptin-Ph (QUB2536), was isolated from skin secretions of the Northern orange-legged leaf frog, Phyllomedusa hypochondrialis. The cDNAs were cloned by molecular cloning and the primary structures of their respective …
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Identification, Molecular Cloning and Functional Characterisation of Novel Bioactive Peptide Drugs from Amphibian Skin Secretions
… inhibit the activity of trypsin. The novel dermaseptin peptide, QUB-2949, had broad-spectrum anticancer activities against human cancer cell lines including PC-3 (ATCC-CRL-1435), U251MG (ecacc-09063001), H157 (ATCC-CRL-5802), MCF-7 (ATCC-HTB-22) and MDA-MB-435S (ATCC-HTB-129). Meanwhile, …
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A novel bioactive peptide from the defensive skin secretion of Phyllomedusa sauvagii
… (ALWKNMLKGIGKLAGQAALGAVKTLVGAE) belonged to the dermaseptin family. QUB-2909 was then synthesised by use of solid phase peptide synthesis. After being purified by RP-HPLC, the novel synthetic peptide was used to test for biological functions.<br/><br/>The novel peptide QUB-2909 showed low …
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Identification and functional study of a bioactive peptide QUB-2007 from the skin secretion of the bicolour tree-frog Phyllomedusa bicolor
… belonging to the Phylloseptin family of the Dermaseptin superfamily, was derived from the skin secretion of Phyllomedusa bicolor. The peptide sequence was obtained by molecular cloning through constructing a cDNA library with isolated mRNA from frog skin secretion. The peptide was synthesised …
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Assessing bioactivity of a peptide from the skin secretion of the central American red-eyed leaf Frog, Agalychnis callidryas
… a peptide related to the plasticins from the dermaseptin superfamily, was isolated from the skin secretion of the Central American Red-eyed Leaf Frog, Agalychnis callidryas. A cDNA library was constructed by using the isolated mRNA from frog skin secretion and ‘shotgun’ cloning, through use of …
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Exploring the Pharmacological Potential of Bioactive Peptides in Amphibians and Plants: from Identification to Rational Design
… mammals, plants and many other sources. Here, Dermaseptin-PC (DM-PC) and PLX-PC, two novel AMPs (antimicrobial peptides), were discovered from the skin secretion of a tree-dwelling, South American frog (Phyllomedusa coelestis), using the combination of ‘shotgun’ cloning and tandem mass …
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QUB-2825: A novel bioactive peptide from the skin secretion of Phyllomedusa hypochondrialis
… treatment of multi-drug resistance microbes. The dermaseptins consist of a superfamily within amphibian AMPs, which also possess anticancer activities with weak haemolytic effect. <br/><br/>My research aims at searching for a novel bioactive peptide from the skin secretion of the Northern …
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Identification, isolation and bioactivity assessment of a novel peptide from the skin secretion of the Tiger-striped Leaf Frog (Phyllomedusa tomopterna)
… experiments, the novel peptide QUB-2982 from the dermaseptin family displayed potent bacteriostatic and bactericidal activities against Gram-positive and Gramnegative bacteria. Moreover, it exerted its antiproliferative influence on multiple cancer cells, without killing effects towards normal …
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Identification and functional study of the bioactive peptide QUB-2830 from the skin secretion of the blue-side leaf frog, Agalychnis annae
… thesis, QUB-2830, a peptide belonging to the Dermaseptin superfamily, was discovered in the skin secretion of the Blue-side leaf frog (Agalychnis annae). The peptide sequence was obtained by molecular cloning through constructing a cDNA library with isolated mRNA from frog skin secretion. The …
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Identification and evaluation of the bioactive peptide QUB-2925 from the defensive skin secretion of Phyllomedusa tomopterna
… In this thesis, QUB-2925 is described as a Dermaseptin superfamily peptide derived from the skin secretion of Phyllomedusa tomopterna. The main purpose of this study was to evaluate the multiple biological activities of this peptide. The cDNA library was constructed from mRNA isolated from …
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Identification and evaluation of bioactive peptides from amphibian skin and rational design of new analogues
… on them. In chapter 3, DRP-AC4, a novel dermaseptin family peptide was isolated and identified. DRP-AC4 possesses broad-spectrum antimicrobial activity and inhibits the proliferation of a wide range of cancer cells. In chapter 4, another novel peptide named Temporin-LTd was identified. …
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Discovery of bioactive peptides from amphibian skin secretion
… activity. <br/><br/>In Chapter 4, a novel dermaseptin peptide, QUB-2522, was identified from the defensive skin secretion of the Northern orange-legged leaf frog, Phyllomedusa hypochondrialis. It exhibited antimicrobial activity against the bacteria, S. aureus and E. coli, at 32 μM …
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