Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"derivatisation"”.
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Supramolecular derivatisation of new anti-tubercular and antimalarial drug leads
The UCT Drug Discovery and Design Centre, H3D, provided anti-tubercular and antimalarial drug leads that display potent in vitro and in vivo activity, but with unfavourable physicochemical properties. The primary objective of this study was to prepare supramolecular derivatives of the drug leads in …
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Supramolecular derivatisation of bioactive molecules via co-crystallization and cyclodextrin inclusion complexation
The objective of this study was to modify the physicochemical properties of two common drugs via supramolecular derivatization. Sulfasalazine is a powerful anti-inflammatory drug and fluconazole has a strong antibacterial and antifungal activity. The common feature is their very low solubility in …
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The supramolecular derivatisation of pharmaceutically relevant compounds via co-crystallization and cyclodextrin inclusion complexation
The supramolecular derivatisation of pharmaceutically relevant compounds via co-crystallization and cyclodextrin (CD) inclusion complexation was attempted in order to produce new solid forms of these compounds for potential pharmaceutical applications. The pharmaceutically relevant compounds …
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A comparison of derivatisation procedures for the detection of multiple analytes in systematic forensic toxicology
Three different derivatisation procedures were evaluated for their general applicability to systematic toxicological analysis (STA) involving (a) acylation with pentafluoropropionyl anhydride (PFPA) and pentafluoropropanol (PFP-OH), (b) acylation/esterification (methylation) with …
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Comparing diene derivatisation methods of dry blood spot samples for vitamin D metabolites quantification by liquid chromatography-tandem mass spectrometry
… describes the elucidation and implementation of derivatisation in the quantification of biologically active vitamin D metabolites in limited volume serum and dry blood spot samples (DBS) using the liquid chromatography tandem-mass spectrometry (LC-MS/MS) analytical technique. This manuscript …
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Applications of LC-MS metabolomic profiling in inflammatory bowel disease and the development of derivatisation methods to enhance selective detection of certain compound classes
… and lactic acids was developed by carrying out derivatisation of the acids using a carbodimide to activate the acids and then reacting with dimethylaminophenylamine and separating the derivatives using HILIC chromatography. Quantification was carried out by using stable isotope dilution. The …
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ANALYSIS OF PHARMACEUTICALS AND BIOMOLECULES USING HPLC COUPLED TO ICP-MS AND ESI-MS
… propylamine bromide (TMPP) was used for the derivatisation of maleic, fumaric, sorbic and salicylic acids to facilitate determination by HPLC-electrospray ionisation tandem mass spectrometry (ESIMS/ MS) in positive ion mode. Improvements in detection limits post-derivatisation were achieved, …
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Hydroxyl functionalities of middle rank british coals
… involving both microwave-driven and bench top derivatisation of the hydroxyl functionalities present in coal. These hydroxyl groups are predominantly in the form of hindered phenolic groups, with other alcoholic groupings being less important, in the coals studied here. Four different …
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The remediation of tributyltin-contaminated dredgins and waters
… the sediments, a triple extraction followed by derivatisation and measurement by gas chromatography with pulsed flame photometric detection was employed, avoiding the lengthy concentration step of the organic layer. The TBT detection limit of ca 0.04 mg Sn/kg in sediment was below the suggested …
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Liquid chromatography-mass spectrometry, an evolution in doping analysis
… is limited and prior to GC-MS analysis, derivatisation is required for most of them. Unfortunately, some derivatives are thermal labile and can not be detected. Liquid chromatography hyphenated with mass spectrometry (LC-MS) does not require a derivatisation step. This analytical …
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Detection and analysis of spin trapped radical adducts using thermal desorption gas chromatography mass spectrometry (TD-GC-MS)
… production in low quantities and need of derivatisation aresome of the challenges faced by analytical chemists to detect them. In the currentresearch, aldehydes are used as secondary source of radicals in the Fenton reaction toproduce aldehyde related free radicals. The developed method is …
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The use of MALDI-MS for imaging drug disposition in respiratory disease models.
… efficiencies of the carbonyl functionalities. Derivatisation with hydrazine based reagents has been proposed as a solution to this problem. These reagents have been employed for the in-solution and on-tissue derivatisation of a range of glucocorticoids to form their respective hydrazones …
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Synthesis and evaluation of novel ellipticines as potential anti-cancer agents
… the group utilising vinylmagnesium bromide, derivatisation of the C5 position of ellipticine was accomplished by reaction of a key ketolactam intermediate with Grignard reagents. Corresponding attempts to introduce diverse substitution at the C11 position were unsuccessful, although one novel …
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Development of a Novel Bioconjugation Platform for the Generation of Homogenous Antibody-Drug Conjugates
… The secondary aim of this work was the derivatisation of these linkers to allow for the facile modulation of DAR in integer increments. Both of these goals could be achieved by the development of a novel class of disulfide rebridging linkers, based on the previously reported …
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Supramolecular modification of selected antiretroviral drugs
… ideal candidates for attempted supramolecular derivatisation. The primary objective of this study was to carry out cocrystal screening and attempt cyclodextrin complexation with nevirapine, efavirenz, lamivudine and zidovudine, with a view to identifying and isolating new solid forms of these …
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Development and application of isotopically-selective assays for nitric oxide metabolites.
… [15]N : [14]N. The time of analysis, excluding derivatisation by the Griess assay, was approximately 5 minutes. The method will be useful in metabolic tracer studies using stable labels. An alternative assay using ion chromatography - mass spectrometry allowed the detection of nitrite and …
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LC-ESI-MS/MS quantification of hair cortisol, cortisone and DHEA in combined oral contraceptive users
… enhanced the sensitivity of all analytes without derivatisation. This was, however, insufficient for the low levels of DHEA in hair. Derivatisation was then used to improve DHEA sensitivity but was unfavourable for cortisol. Since cortisol was the most important metabolite in this study, the …
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The reconstitution of the histone octamer
… of an octamer suitable for the sitespecific derivatisation of a specific histone, or covalently labelled with aurothiomalate in a specific histone complex. These studies were concluded to represent general labelling strategies which may be of use in crystallographic or physico-chemical …
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Synthetic efforts towards the total synthesis of the Nucleoside Antibiotic, (+)-Amicetin
… routes incorporate this belief, and allow for derivatisation at specific sites within the amicetamine fragment.<br/><br/>Further to this a route to the cytimidine fragment was well developed, with a limitation in the coupling sequence revealed of significant importance to any future chemist …
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Human brain lipid fatty acid composition in relation to infant diet
… gas liquid chromatography after extraction and derivatisation. The subjects were divided according to their dietary history, either breast or formula feeding. Formula-fed infants were further subdivided according to the content of -linolenic acid in the formula milk. At the time of this study no …
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