Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"depressive-like behavior"”.
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Antidepressant effect of pramipexole in a dexamethasone induced depressive-like behavior model
Resumo: A depressão é um distúrbio psiquiátrico comum caracterizado por diversos sintomas debilitantes como a desesperança e a anedonia. Apesar de a fisiopatologia do distúrbio ainda não estar completamente elucidada, evidências demonstram a associação entre a depressão e disfunções do sistema …
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ASSESSING THE EFFECTS OF KETAMINE AND ITS ENANTIOMERS ON COMPULSIVE-LIKE AND DEPRESSIVE-LIKE BEHAVIOR
… serotonin reuptake inhibitors (SRIs), cognitive behavioral therapy (CBT), or a combination of these treatments. Despite medical advancements, current treatments are not effective for a large percentage (~33%) of people and often have a delayed onset of 8 to 12 weeks. The inability to effectively …
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Voluntary wheel running mitigates hyperglycemia-induced depressive-like behavior and increases hippocampal BDNF levels in male mice.
… decreasing neurotrophy. While exercise reduces depressive symptoms in other models of depression, limited research has investigated the efficacy of exercise-related interventions in hyperglycemia-associated depression. Thus, we examined whether chronic exercise could rescue hyperglycemia-related …
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The effect of mild traumatic brain injury on cytokine expression in brain tissue
… (mTBI) results in significant cognitive and behavioral learning deficit, as well as long-term depressive like behavior in mice. mTBI has been identified as a major initiating event in long-term depressive-like behavior and early fatality observed in soldiers returning from conflicts in Iraq …
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Effects of voluntary wheel running and forced treadmill running on inflammation induced behavioral abnormalities in young and old mice
… system output, endocrine system output, and behavior to regulate the body’s response to infection. One host factor affecting the behavioral response to infection is aging. Due to microglia priming and exacerbated neuroinflammation, aged individuals exhibit prolonged sickness behavior and …
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Investigação de parâmetros bioquímicos em dois modelos animais de depressão induzidos por desamparo aprendido e administração do lipopolissacarideo de E.Coli
… oxidative damage on serum and PFC and helpless behavior. There was no difference in the concentration of IL-1β, TNFα, IL-6 and IL-10 cytokines on PFC and hippocampus of the animals exposed to the learned helplessness test, but there was a significant positive correlation between IL-6 …
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Investigating the Enteroendocrine - Brain Axis: Ghrelin Cell and ECL Cell Physiology and Ghrelin Action on Mood and Complex Eating
… ghrelin's effects on mood and complex eating behaviors. At the cellular level, little is known about the ghrelin cell's transcriptional profile, its secretory products other than ghrelin, and its relationship to other gastric endocrine cells, such as the histamine producing …
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Functional characterization of Phosphodiesterase-4A in behavior and obesity
… that PDE4D is highly involved with memory and depressive-like behavior, and PDE4B is involved with anxiety and release of inflammatory factors from immune cells; however, the functional role that PDE4A plays in behavior was not known. The purpose of this dissertation was to characterize the …
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Biobehavioral responses to immune skew and free fatty acids
A well-described set of biobehaviors and cognitive dysfunction emerge after stimulation of the immune system with pathogen-associated or danger-associated molecular patterns, and the endogenous cytokines elaborated in the immunologic response are key effectors (Dantzer et al., 2008). Just as an …
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Circadian Disruption by Light at Night: Implications for Mood
… solar cycle. Circadian rhythms in physiology and behavior remain synchronized to the environment using light as the most potent entraining cue. During the past century, however, the widespread adoption of electric light has led to `round-the-clock’ societies. Instead of aligning with the …
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The differential effects of short-term physical exercise, environmental enrichment and their combination, and short- and long-term environmental enrichment on behavior and associated molecular changes in the brain of C57BL/6 mice
… is impaired cognition, enhanced anxiety- and depressive-like behaviors, and reduced locomotor activity, accompanied by neurobiological changes, such as enhanced inflammation, decreased neurotrophins, and altered neurotransmitter levels. Evidence suggests that external environmental conditions …
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EXAMINING SEX DIFFERENCES IN NEUROBIOLOGICAL AND BEHAVIORAL CHANGES INDUCED BY CHRONIC INTERMITTENT ETHANOL VAPOR EXPOSURE IN LONG EVANS RATS
… from CIE exposure induces an increase in anxiety-like behavior and an increase in hippocampal excitability in male rats. We also found that this increase in excitability is largely restricted to the ventral domain of the hippocampus (VHC). Although relatively few studies have examined the effects …
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Development of a Mouse Model of NY99 West Nile Virus-Induced Neurological Changes
… certain brain regions correlated with changes in behavioral tests investigating depressive-like behavior, sensorimotor gating, and motor learning, though there was no correlation with memory function. These studies show that this mouse model of WNV infection causes long-term changes in the brain …
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Developmental Monoamine Signaling Impacts Adult Affective and Aggressive Behaviors
… periods for the indelible modulation of complex behaviors is similar to that described for sensory systems (e.g. visual cortex, ocular dominance plasticity), but effected behaviors, modulating factors, and underlying mechanisms are much less well understood. Furthering our knowledge of sensitive …
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Rats selectively-bred for low and high voluntary running: co-selected traits and the effects of voluntary running on the dentate gyrus transcriptome
… for low (LVR) and high (HVR) voluntary running behavior as a model for examining the genetic and physiological origins of physical activity motivation. The major advantage of selective breeding over non-natural methods of genetic engineering is the perpetuation of naturally-existing, polygenic …
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Neuroendocrine mechanisms of behavioral changes induced by hypoglycemia
… is associated with a variety of adverse behaviors including fatigue, confusion, social withdrawal, anhedonia and depressive-like behaviors. While these clinical symptoms are well characterized, the mechanisms of their cause are not understood. Here, we investigated how insulin-induced …
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Papel do sistema peptidérgico da nociceptina/orfanina FQ no comportamento depressivo em camundongos
… N/OFQ-NOP receptor system in the modulation of depressive-like behaviors in mice. Methods: Male Swiss and CD-1 mice and mice knockout for the NOP receptor (NOP (-/-)) were used in this study. The forced swimming test (FST) and the learned helplessness model (LH) were used to evaluate the …
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Modulation of bio-behaviors and diabesity by dietary factors
… the modulation of weight, blood metabolites, bio-behaviors, and neuro-immune function by a high fat diet. C57BL/6J male mice were fed a 60% fat diet (high fat diet; HFD) or a 10% fat (low fat diet; LFD) for 1 or 3 weeks post-weaning, after which mice were subjected to behavioral testing. HFD-fed …
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Possibile ruolo del sistema endocannabinoide nel disturbo d’alimentazione incontrollata (binge eating disorder): studi comportamentali, farmacologici e biochimici
… of time, without the inappropriate compensatory behaviors for limiting weight gain. BED is a stable condition that is associated with elevated psychiatric comorbidity, including depression and anxiety. A large body of evidence supports a contribution of the endocannabinoid system in the …