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Showing 1 to 2 of 2 for “"depolarizing spontaneous fluctuations"”.

  1. Behavioral Insights Into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms In Rats

    … potential generation, and 3) enhancement of depolarizing spontaneous fluctuations (DSFs) in MP. <em>In vitro</em> modeling of acute inflammation by combining serotonin with artificial depolarization also potentiated DSFs and OA. These findings reveal nociceptor specializations for generating …

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  2. Investigating Mechanisms In Nociceptors Driving Ongoing Activity and Ongoing Pain

    <p>Ongoing (apparently spontaneous) pain at rest is a major complaint of patients suffering from many forms of acute and chronic pain, including acute and persistent postsurgical pain. Accumulating evidence suggests ongoing activity in nociceptors is a major driver of ongoing pain. Ongoing activity …

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