Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 156 for “"dephosphorylation"”.
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Fas-induced apoptosis: dephosphorylation and cleavage of the retinoblastoma protein leads to cell cycle arrest
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characterization of the specificity and functions of the protein phosphatase Cdc14
… and regulatory cellular outcomes. For example, dephosphorylation of a protein at a particular site may inhibit nuclear localization of a protein while dephosphorylation of a different site may be necessary for enzymatic activation of a protein. Thus, multisite protein phosphorylation can …
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Association of Protein Phosphatase 2A with S6 Kinase Is Regulated In an MTOR-Dependent Manner
… Many reports have demonstrated the rapid dephosphorylation of S6K1 following treatment with the mTOR inhibitor, rapamycin, as well as by the depletion of amino acids. These data suggest a role for a serine/threonine protein phosphatase in mediating this dephosphorylation. This was …
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The B55α/PP2A Holoenzyme in Cell Cycle Exit, Maturation/Differentiation, and Cancer
… of p107/PP2A/B55α complexes coinciding with p107 dephosphorylation without an increase in B55α protein expression in RCS cells. Reciprocal solution-based mass-spectrometry analysis identified the PP2A/B55α complex as a major component of a subset of p107 complexes, which also contain E2F/DPs, …
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Studies on the role of CheS in Sinorhizobium meliloti chemotaxis
… flagellar rotation. Signal termination by dephosphorylation of the response regulator is necessary for the organism to react rapidly to changes in the environment. The phosphorylated response regulator CheY in <i>Escherichia coli</i> is dephosphorylated by CheZ, a phosphatase; certain …
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ATM-Dependent ERK Signaling in Response to DNA Double Strand Breaks
… higher doses (≥ 5 Gy eq.) resulted in Em1/2 dephosphorylation. ERK1/2 phosphorylation was ATM-dependent, whereas dephosphorylation was ATM-independent and DSBs dose-dependent. Thus ERK1/2 appear to be both positively and negatively regulated by ATM depending on the severity of the insult to …
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Differential Regulation of Phosphatidylinositol 4-Phosphate 5 Kinase Beta during Hypertonic and Oxidative Stress
… through PP1 phosphatase dependent ser/thr dephosphorylation which leads to increased kinase activity and plasma membrane localization. The PIP2 produced by PIP5Kbeta during this event leads to an increase in actin polymerization and stress fiber formation. Conversely, oxidative stress leads …
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Regulation of DNA replication by PP2A family phosphatases
… PP4, as the phosphatases responsible for Sld3 dephosphorylation and partially of Sld2. To overcome the pleiotropy of these phosphatases hindering S phase analysis, I identify the Sld3-PP2A-RTS1 interaction site and mutation of this site affects Sld3 dephosphorylation in S phase and at mitotic …
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
… the striatum, basal in vivo phosphorylation and dephosphorylation of Ser6 were mediated by Cdk5 and protein phosphatases 2A (PP-2A) and 1 (PP-1), respectively. Additionally, protein phosphatase 2B (PP-2B) contributed to dephosphorylation under conditions of high Ca2+. Functionally, Cdk5-dependent …
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The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells
… SHIP2 is a 5-phosphatase that catalyzes the dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P 3) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) as well as the dephosphorylation of phosphatidylinositol 4,5- bisphosphate (PI(4,5)P 2). PI(3,4,5)P 3 and P][(4,5)P 2 …
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Canonical and non-canonical regulation of AMP-activated protein kinase
… by upstream kinases and protects AMPK from dephosphorylation of Thr172 by protein phosphatase(s). In 2010 it was reported that oxidative stress mediated by H<sub>2</sub>O<sub>2</sub> activated AMPK by increasing the cellular AMP:ATP and ADP:ATP ratios (Hawley et al, 2010). However, the same …
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Modelling Β2Ar Regulation
… in response to various LABAs/SABAs; (ii) dephosphorylation of the GRK site on the β2AR; (iii) β2AR internalisation; (iv) β2AR recycling; (v) β2AR desensitisation; (vi) β2AR resensitisation; (vii) PKA-mediated β2AR phosphorylation in response to a SABA; and (viii) LABA/SABA induced cAMP …
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Regulation of Ca2+-Activated K+ Channel: Changes with Development
… protein kinases and phosphatases-phosphorylation/dephosphorylation can change BK channel activity.</p> <p>The hypothesis that <em>Ca<sub>0</sub></em> is modulated by phosphorylation was further tested. This study showed that phosphorylation and dephosphorylation do not change voltage or …
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Relative allergenicity of modified bovine milk proteins
… allergenicities of both caseins after enzymic dephosphorylation were also investigated. In addition, the relative allergenicity of whey after the partial removal of S-lactoglobulin by FeCl3 precipitation was studied. The relative allergenicity of the milk proteins was determined by the passive …
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Unraveling the Dynamics of Ser126 Phosphorylation in Paxillin: A Focus on Phosphatase Activity
… cells revealed that calcineurin mediates Ser126 dephosphorylation. Phosphorylation at Ser126 enhances paxillin localization to focal adhesions, suggesting a dynamic regulatory mechanism in endothelial cell signaling.
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… aggregation under stirring condition results in dephosphorylation of the Thr410 residue, which can be prevented by blocking integrin alpha IIb beta 3 by its antagonist SC-57101 (p<0.01). The dephosphorylation of Thr410 can also be prevented by okadaic acid, a Ser/Thr protein phosphatase …
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Biochemistry and molecular biology of binding proteins for plant growth regulators.
… acid (N~A) receptor through phosphorylation and dephosphorylation and the regulation of the auxin binding protein (ABP) through gene manipulation have been investigated. NPA, an auxin transport inhibitor, was found to bind specifically to a crude membrane preparation from sugar beet seedling leaf …
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Pyp3 Involvement in Mitotic Control and Cell Growth in Fission Yeast
… yeast, Schizosaccharomyces pombe, tyrosine dephosphorylation of p34cdc2 is required for mitotic initiation and this reversible tyrosine phosphorylation plays a crucial role in the regulation of the cell cycle. The kinases wee1+, mik1+ and the phosphatases cdc25+, pyp3+ play opposite roles in …
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The Role of [beta]2-Syntrophin Phosphorylation in Secretory Granule Exocytosis
… Ca2+-dependent and okadaic acid-sensitive dephosphorylation upon stimulation of insulin secretion. Stimulation-dependent dephosphorylation was confirmed by immunoprecipitation of 32P-labeled GFP-b2-syntrophin.Mass spectrometry of immunoprecipitated GFP-b2-syntrophin allowed the …
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