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Showing 1 to 1 of 1 for “"deoxyxylulose-5-phosphate reductoisomerase (Dxr)"”.
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Toward the synthesis and evaluation of novel N-acylated FR-900098 analogs
… to be potent inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a necessary enzyme in Plasmodium for isoprenoid biosynthesis via the non-mevalonate pathway, which does not exist in humans. Although FR-900098 was determined to be about twice as potent as fosmidomycin, it is important …