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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 4 of 4 for “"deoxycytidine kinase"”.

  1. DEVELOPMENT OF 4'-ETHYNYL-2'-DEOXYCYTIDINE (EdC), A REPLICATION-STRESS INDUCING NUCLEOSIDE ANALOG PRODRUG WITH PREFERENTIAL ACTIVITY IN LEUKEMIA AND LYMPHOMA SUBTYPES

    Calbert, MarissaTemple University. Libraries2024

    … screening approach, we discovered 4’-ethynyl-2’-deoxycytidine (EdC) as a third-generation anticancer nucleoside prodrug with preferential activity against diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL). EdC requires deoxycytidine kinase (dCK) phosphorylation for its …

    temple Repository record

  2. Development and Application of Large-Scale Protein Folding Stability Analysis in Drug Target Identification and Disease Biomarker Discovery

    Ma, Renze2020

    … used to identified two consistent protein hits, deoxycytidine kinase (DCK) and exportin-2 (XPO2), from more than 2000 assayed proteins in a 2B4T cell lysate. The binding of DCK with subglutinol A was validated using a targeted gel-based pulse proteolysis experiment. A set of chemical biology …

    duke Repository record

  3. Structure-function studies of mammalian deoxycytidine kinases

    Elena Usova2003

    slu Repository record

  4. Proteindesign zur Verbesserung des Nucleosidanaloga-Umsatzes in menschlichen Zellen: Desoxycytidin-Kinase und UMP/CMP-Kinase

    Ort, Stephan2012

    … Nucleosid- und Nucleosidmonophosphat-Kinasen spielen eine entscheidende Rolle bei der Aktivierung einer Vielzahl von Nucleosidanaloga, die in der Behandlung von Virus- und Krebserkrankungen eingesetzt werden. In dieser Arbeit wurden Enzyme untersucht, die limitierend für die …

    goettingen Repository record