Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"deoxycholic acid"”.
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Development and Evaluation of Selected Chemoprophylaxis Candidates and a Candidate Live-Attenuated Vaccine for Prevention of Histomoniasis in Turkeys
… of histomoniasis. Chapter one addresses deoxycholic acid and a biliogenic diet intended to endogenously increase production of this secondary bile acid. Deoxycholic acid was effective in vitro but failed to prevent histomoniasis when evaluated during the in vivo experimental disease trial …
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Investigating the Potential of Microbial Metabolites and mTOR Signaling on Chicken Necrotic Enteritis
… we investigated the effect of secondary bile acid on necrotic enteritis. Day-old broiler chicks were randomly assigned to 5 groups of diets supplemented with 0 (basal diet), 0.8, 1.0, and 1.5 g/kg (on top of basal diet) deoxycholic acid (DCA). The birds were challenged with Eimeria maxima …
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Exploring the potential application of glucuronides as a prognostic biomarker for disease.
… with the disease: 2-phenylethanol glucuronide, deoxycholic acid 3- glucuronide, and androstanediol glucuronide.
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Molecular selectivity by host-guest methods
… of the trimethoxybenzene (TMB) isomers, cholic acid and deoxycholic acid' hosts were used in chapter 3. It was found that each host separated the isomers differently. That was independent of the closeness of their molecular structures. The difference in selectivity was attributed to the …
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THE BIOTRANSFORMATION OF BILE ACIDS BY A COMMON MEMBER OF THE BISON GUT MICROBIOME
Bacterial biotransformation of bile acids (BAs) is increasingly recognized to play an important role in the health and disease of the host. Bile acid-modifying bacteria participate in the production of a large number of secondary BAs (2 BAs) with known and yet to be discovered activities. In the …
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The Cocaine-Binding Aptamer: A Thermodynamic and Structural Overview of Specific and Non-Specific Binding Interactions
… aptamers. A titration of an equimolar mixture of deoxycholic acid (DCA) and cocaine had an enthalpy of (-32.5 0.2) kcal mol-1. This is comparable to the sum of enthalpies for independent titrations of cocaine and DCA at (-12 5) and (-11 2) kcal mol-1, respectively.
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Novel Cancer Therapeutics, the Generation of ROS, and Cell Survival
… (17-AAG), interacts with the secondary bile acid, deoxycholic acid (DCA), to kill primary rat hepatocytes and HuH7 human hepatoma cells. An effect abolished by the addition of the ROS-quenchers, NAC and Trolox. Collectively, these findings argue that geldanamycins may not be a viable therapy …
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Development of a Transformation System for Caldariomyces Fumago and Expression of Heterologous Proteins
… (40 to 50%) and sensitivity to antibiotics. Deoxycholic acid was shown to increase sensitivity while yeast extract and bacto-agar decreased it. Spheroplasts were transformed by polyethylene glycol (PEG) fusion with plasmid DNA. The DNA contained a hygromycin B resistance gene (hph), which …
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ENZYMOLOGY AND MOLECULAR BIOLOGY OF BILE ACID 7alpha- AND 7beta- DEHYDROXYLATION BY THE INTESTINAL BACTERIA CLOSTRIDIUM SCINDENS AND CLOSTRIDIUM HYLEMONAE
… "the second human genome project". Bile acids, endogenously produced by the host liver, represent both a strong selective pressure for potential colonizers, aswell as substrates for microbial metabolism. Indeed, microbes have evolved enzymes to deconjugate bile salts, epimerize bile acid …
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Steroid metabolism in the human gut by microbial hydroxysteroid dehydrogenases
Bile acids and cortisol are steroid hormones derived from cholesterol that are important signaling molecules in the human body. Bile acids are essential for nutrient solubilization and absorption in the gut while cortisol is involved in stress response and metabolism throughout the body. The gut …
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Design and Synthesis of Cellulose Ether Derivatives for Oral Drug Delivery
… involve relatively harsh conditions (strongly acidic or strongly alkaline), greatly limiting the content and range of functional groups that may be installed onto the cellulose backbone. Amorphous solid dispersion (ASD) is an effective method to promote oral delivery of poorly-soluble drugs by …