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Showing 1 to 20 of 69 for “"dengue virus"”.

  1. Dengue Virus Host Factors

    <p>Dengue fever and dengue hemorrhagic fever are estimated to afflict 50-100 million people annually and are caused by one of the four serotypes of dengue virus. Dengue virus is carried and transmitted to humans by mosquitoes of the Aedes genus. Given the broad geographic distribution of Aedes …

    duke Repository record for Dengue Virus Host Factors (opens in a new tab)

  2. Dengue virus and West Nile virus protease inhibitors

    wichita-thes

  3. A Structural Perspective of Antibody Neutralization of Dengue Virus

    <p>The four dengue viruses: DENV) are mosquito-borne flaviviruses and are considered the world's most significant arboviruses in terms of worldwide disease burden. Symptoms of dengue disease are classified into dengue fever, a mild, febrile illness, and the potentially fatal severe dengue, which …

    wustl Repository record for A Structural Perspective of Antibody Neutralization of Dengue Virus (opens in a new tab)

  4. Characterization of intracellular interactions between dengue virus and host proteins

    <p>Dengue virus is the causative agent of dengue fever, dengue hemorrhagic fever and dengue shock syndrome. About two-fifths of world population live in areas where dengue is prevalent, leading to high levels of morbidity and mortality in many areas. Currently there are no vaccines or effective …

    wayne-thes Repository record for Characterization of intracellular interactions between dengue virus and host proteins (opens in a new tab)

  5. Thioaptamers Targeting Dengue Virus Type-2 Envelope Protein Domain III

    The Dengue Virus Type-2 (DENV-2) is an arbovirus that belongs to the family of Flaviviridae, genus Flavivirus. It includes Dengue virus (DENV) types 1-4, West Nile virus, Langat virus, Omsk hemorrhagic fever virus and others that cause encephalitic or hemorrhagic disease. DENV binds the cell …

    utmb Repository record for Thioaptamers Targeting Dengue Virus Type-2 Envelope Protein Domain III (opens in a new tab)

  6. Characterization of the antiviral activity of cyclosporine A against dengue virus

    Dengue virus (DENV) currently threatens 3.9 billion people, a number expected to rise to 6.1 billion by 2080, yet no specific antiviral treatments are available despite 80 years of research. Cyclosporine A (CsA), an immunosuppressive drug, has emerged as a potential broad-spectrum antiviral …

    queens Repository record for Characterization of the antiviral activity of cyclosporine A against dengue virus (opens in a new tab)

  7. Investigation of dengue virus RNA terminal region interactions with human host proteins

    lethbridge

  8. Isolation and characterization of dengue virus membrane-associated replication complexes from Aedes aegypti

    Ultrastructural studies of flavivirus replication have long observed proliferation of host membranes. Membrane-bound replication compartments have recently been isolated and characterized from flavivirus-infected mammalian cells, providing insight into the morphology, organelle of origin, and …

    colostate Repository record for Isolation and characterization of dengue virus membrane-associated replication complexes from Aedes aegypti (opens in a new tab)

  9. In Vitro and In Vivo Effects of Espirito Santo Virus on Dengue Virus Replication

    Arboviruses have been one of the leading causes of morbidity and mortality worldwide for centuries (Morens et al., 2004). Dengue virus (DENV), Zika (ZIKV), Chikungunya (CHIKV) and West Nile virus (WNV) are some of the medically important arboviruses transmitted by mosquitoes. Dengue is one of the …

    ecu Repository record for In Vitro and In Vivo Effects of Espirito Santo Virus on Dengue Virus Replication (opens in a new tab)

  10. A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice

    The spread of dengue (DEN) worldwide combined with an increased severity of the DEN-associated clinical outcomes have made this mosquito-borne virus of great global public health importance. Progress in understanding DEN pathogenesis and in developing effective treatments has been hampered by the …

    nus Repository record for A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice (opens in a new tab)

  11. Studies on the antibody repertoire in a Dengue virus immune subject and isolation of neutralizing antibodies by phage display technology

    Dengue Virus (DENV) is known as the causative agent of Dengue Fever and Dengue Hemorrhagic Fever / Dengue Shock Syndrome (DHF/ DSS). Infection with one of the serotypes elicits long-term, homotypic protection but does not protect from the risk of development of DHF/DSS upon subsequent infection …

    nus Repository record for Studies on the antibody repertoire in a Dengue virus immune subject and isolation of neutralizing antibodies by phage display technology (opens in a new tab)

  12. Metabolomics-based diagnosis and prognosis of dengue virus infections and NS1 antigen detection for diagnosis and surveillance in humans and mosquitoes

    Dengue (DEN) is a mosquito-borne viral disease of significant public health importance. There are currently no commercialized vaccines or accepted pharmacological treatments for DEN disease, making mosquito surveillance critical for the prevention of outbreaks of this disease. Aedes aegypti is the …

    colostate Repository record for Metabolomics-based diagnosis and prognosis of dengue virus infections and NS1 antigen detection for diagnosis and surveillance in humans and mosquitoes (opens in a new tab)

  13. Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies

    … to mosquito-borne pathogens. Within the Flavivirus genus, dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV) are evolutionarily related mosquito-borne viruses with antigenic similarities. The antigenic similarities present between 4 circulating DENV serotypes create an …

    brock Repository record for Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies (opens in a new tab)

  14. Evaluation of a Tetravalent DNA Vaccine against Dengue: Integrating Biochemical Studies on Dengue Virus Envelope Protein to a Domain-Based Antigen Design.

    Dengue virus (DENV) is among the most important mosquito-borne human pathogens worldwide. Concerns regarding the effectiveness of Dengue vaccines together with emergence of Zika virus (ZIKV) have reignited the interest for new vaccines using alternative approaches. Given that the envelope …

    the-open-u Repository record for Evaluation of a Tetravalent DNA Vaccine against Dengue: Integrating Biochemical Studies on Dengue Virus Envelope Protein to a Domain-Based Antigen Design. (opens in a new tab)

  15. Modeling dengue viral infection, insect transmission and multiplex PCR in humanized mice

    Due to the restricted host specificity of dengue virus, up until now no ideal animal model has sufficiently mimicked key aspects of viral pathogenesis and immune response. In this regard, new advances with humanized mice(hu-mice), constructed by engrafting human tissues and cells and harboring a …

    colostate Repository record for Modeling dengue viral infection, insect transmission and multiplex PCR in humanized mice (opens in a new tab)

  16. Development of Rapid Lateral-flow Immunochromatographic Test for the Diagnosis of Chikungunya Virus Infection

    BACKGROUND/AIMS: Chikungunya (CHIK) virus is a mosquito-transmitted Alphavirus belonging to family Togaviridae that causes a number of outbreaks in Africa, India, and Southeast Asia with high morbidity. The major clinical symptoms resulting from CHIK virus infection are high fever, arthralgia, …

    ajou Repository record for Development of Rapid Lateral-flow Immunochromatographic Test for the Diagnosis of Chikungunya Virus Infection (opens in a new tab)

  17. CHARACTERIZATION OF DENGUE NEUTRALIZING ANTIBODIES USING RECOMBINANT ANTIBODIES TECHNOLOGY

    … ANTIBODIES OBTAINED FROM TWO NATURALLY INFECTED DENGUE PATIENTS. THIS LED TO THE SUBSEQUENT DISCOVERY AND FURTHER CHARACTERIZATION OF AN ANTIBODY THAT POSSESSES POTENT NEUTRALIZATION CAPACITY AGAINST ALL FOUR DENGUE VIRUS SEROTYPES. IN PARALLEL, AN ATTEMPT TO DESIGN ANTIBODIES THAT CAN …

    nus Repository record for CHARACTERIZATION OF DENGUE NEUTRALIZING ANTIBODIES USING RECOMBINANT ANTIBODIES TECHNOLOGY (opens in a new tab)

  18. Is the application of a vulnerability framework effective in determining patterns of the incidence of dengue disease on the island of Dominica? : the Water Associated Disease Index (WADI) model

    … areas of increased risk of transmission to dengue virus as a re-emerging public health threat. Vulnerability will be based on social, ecological, and environmental factors in the Commonwealth of Dominica, a small island nation in the Caribbean. Using a combination of susceptibility (social) …

    lancaster Repository record for Is the application of a vulnerability framework effective in determining patterns of the incidence of dengue disease on the island of Dominica? : the Water Associated Disease Index (WADI) model (opens in a new tab)

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