Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"dendrons"”.
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Synthesis and characterization of polyamidoamine dendrons
… study is to synthesize Poly AMido AMine (PAMAM) dendrons using silica gel as support and characterize them. PAMAM dendron, a hyperbranch of the PAMAM dendrimer, was divergently synthesized on solid support. Prior to the propagation through (1) Michael addition of acryl ester to an amino reactive …
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Self Assembling Bioactive Materials for Cell Adhesion in Tissue Repair
… series of molecules were designed to incorporate dendrons based on amino acids at the termini of the diblock structures. It was determined that lysine, a basic amino acid, covalently coupled to cholesteryl-(L-lactic acid) can promote cell adhesion and spreading while negatively charged and …
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Dendritic rhodium catalyst precursors for the hydroformylation of olefins
… synthesize and characterise a series of Fréchet dendrons bearing rhodium Schiff-base moieties at the focal point, and investigate their potential as catalyst precursors in the hydroformylation of olefins. A series of Fréchet dendrons with methyl ester groups at the periphery were prepared. The …
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Harnessing DNA nanoarchitecture to overcome immunoevasion in cancer
… nanoscale branching DNA architectures, known as dendrons, to (1) encode and deliver a DNA sequence, termed G3YSD, capable of activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway; and (2) deliver epigenetic modifiers to reprogram immunosuppressive cues in …
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Hyperbranched polymers and Haag type dendrimers for the molecular imprinting of polymers
… polyglycerol and Haag type polyether dendrons with estradiol as a core. The attachment of the polyether dendron created a dendrimer that had 64 allyl groups available for crosslinking. Completion of the crosslinking of the dendrimer resulted in a polymer that was not fully crosslinked, …
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Biomimetic models for redox enzyme systems
… and noncovalent behaviour. A series of dendrons have been synthesised and studied that have a water-soluble dendron architecture attached to the flavin moiety, as well as a series of dendrons with branching designed to encapsulate the flavin unit. Finally, a biomimetic model of the …
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Star Polymers and Dendrimers Based on Highly Functional Resorcin- and Pyrogallolarenes
… with different number of arms and accordingly dendrons, based on calix[4]resorcin- and calix[4]pyrogallolarenes, via convenient polymerization and generation growth reactions and analysis of the obtained products by different methods (MALDI-TOF-MS, SEC-RI and SEC-MALLS, NMR).
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Preparing Biological surfaces with well defined density and spatial distribution
… interactions and the steric bulk of dendrons (to achieve the spacing). In order to do this, the axle component of a pseudorotaxane complex would have to be synthesised and absorbed to the surface via covalent bonding (chemisorption) to create a self-assembled monolayer (SAM). This is …
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The Synthesis and Study of Dendrimers and Star Polymers Without Cores
… with cross-linking. In addition, smaller dendrons and a dendrimer having 16 alkene groups were cross-linked, and the resulting structures were analyzed by 1H NMR, x-ray crystallography, MALDI-TOF MS, and SEC to provide insight into the types of the cross-links that are preferred in the …
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Design, Synthesis, and Characterization of Glycodendrons Through Small Molecule and Linear Polymer Models
… conditions for small molecules and glycopolymers/dendrons, and a description of the characterization methods utilized. In chapter three, the effectiveness of the synthetic routes and results from the characterization methods are discussed. Chapter five covers the conclusions of this thesis as well …
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Electronic Energy Transfer in Conjugated Organic Dendrimers and Polymers
… spectroscopy on specially synthesized PA dendrons, and comparison with ab initio calculations. The results are explained by using a variable coupling exciton model. Coherence effects in a model two-level system with trap are examined using Haken-Strobl model with the goal of illustrating …
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EXPANDING APPLICATIONS OF IRON OXIDE NANOPARTICLES BY SURFACE FUCNTIONALIZATION: FROM MAGNETIC RESONANCE IMAGING TO NANO-CATALYSIS
… strategy was established. The Simanek dendrons (G1 to G3), oligonucleotides and amino acids were loaded onto SPION surfaces via this approach to develop pH-sensitive MRI contrast agents, specific-DNA MR probes and a biomimetic hydrolysis catalyst. Dendron-SPION conjugates (G1 to G3) …
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Site-Isolation, Intramolecular Energy Transfer, and Crosslinking in Synthetic Dendritic Quinacridones
… was achieved by attaching bulky poly(aryl ether) dendrons to the quinacridone at the amino functional groups. Both benzyl- and t-butyl-terminated dendrimers were synthesized up to the third generation. These dendrimers showed enhanced solubility in organic solvents due to reduced aggregation and …
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Design, Synthesis and Catalytic Evaluation of Mono- and Polynuclear Organometallic Materials as Hydroformylation Catalysts
… homogeneous species. A series of Fréchet-type dendrons with methyl ester groups at the periphery were subsequently prepared. The α-diimine (DAD) Schiff base ligands were synthesised and coupled to the Fréchet-type dendrons via a Williamson ether reaction to yield a new series of alpha-diimine …
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Chemical functionalization and modification of Au clusters
… the divergent method does not give fully uniform dendrons at higher generations. Finally, the catalytic activity of these Au cluster-cored dendrimers has been studied for the reduction of 4-nitrophenol.
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Supramolecular Assemblies: Dendrimers, Linear Arrays, and Polypseudorotaxanes
… 1st, 2nd, and 3rd generations of benzyl ether dendrons bearing dibenzo-24-crown-8 moiety. The wholly complexed self-assembling dendrimers were evidenced by 1H NMR spectroscopy and mass spectrometry. Linear supramolecular pseudorotaxane polymers were formed with reversible chain extension in …
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Studies of multicomponent assemblies
… binding of the dendrimers to large polyanionic dendrons with increasing numbers of charges was studied. Through these studies, the thermodynamic values of the binding events were obtained allowing us to explore the properties of the dendrimers. The cooperativity of the system was measured, and …
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Designing a safe dendronised polymeric nanocarrier for hydrophobic drugs or gene delivery in cancer therapy
… block copolymers based on hydrophobic dendrons have shown to be a promising strategy to enhance the solubility of hydrophobic drugs, prolong circulation time, minimise non-specific uptake, and allow for specific tumour-targeting through the EPR effect. Herein, we have proposed the …