Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"dendritic spine density"”.
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Dendritic Spine Density Varies Between Unisensory and Multisensory Cortical Regions
In the brain, the dendritic spine is a point of information exchange that extends the neuronal surface on which synapses occur, as well as facilitates and stabilizes those contacts. Furthermore, dendritic spines dynamically change in shape and number in response to a variety of factors. Dendritic …
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A role for the SHANK1 scaffold protein in experience-induced synaptic plasticity and memory consolidation
… Specifically, numerous studies have suggested dendritic spine plasticity across development and during learning as a likely process for memory consolidation. During early postnatal development, dendritic spine density increases in numerous sensory cortices, reaching a peak in adolescence, …
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The Role of Nogo-A in Memory and Neuronal Plasticity in the Aged Rodent Brain
… intact pathways to denervated areas, as well as dendritic sprouting and increased dendritic spine density in the contralateral sensorimotor cortex. In the present project we aimed to investigate whether anti-Nogo-A immunotherapy improves performance on a spatial memory task after a sensorimotor …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
… including lower parvalbumin labeling and lower dendritic spine density, features similar to those observed in human condition. GluN2C heterozygous and knockout mice also exhibit behavioral and cognitive deficits relevant to schizophrenia. Moreover, a GluN2C/GluN2D potentiator, CIQ, attenuated …
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Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… of hippocampal synaptic plasticity, including dendritic spine density, synapse density, and synaptic protein expression. In some cases, these changes are associated with alterations in mood and hippocampal-dependent learning and memory. The upstream mediators of these estradiol effects remain …
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Development and characterization of novel transgenic techniques for the study of neuronal circuitry
… experience a 15% - 19% decrease in apical dendritic spine density. Finally, we also describe the attempt to create additional Cre-driven mouse lines that would allow conditional alteration of neuronal activity either by hyperpolarization or inhibition of neurotransmission. Overall, the …
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Critical window in autism : a study on Shank3
… a novel neuronal tracing technique to study the dendritic spine density, and found that the dendritic spine number is also significantly increased in the rescue condition after development. In addition, we show that while anxiety and motor coordination are not improved, social interaction and …
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The Role of High-Density Lipoproteins and Related Pathways in Alzheimer’s Disease
… established that high plasma levels of high-density lipoprotein (HDL) protect against cardiovascular disease and accumulating evidence indicates that the beneficial role of HDL extends to the central nervous system. There are several important biological mechanisms that regulate HDL …
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Anatomical and Functional Characterization of the Ventral Hippocampus in a Rodent Model of Schizophrenia Neuropathology
… Specifically, we found a decrease in dendritic spine density in specific regions of the dendrite of ventral subicular neurons. At the neurophysiological level, we observed abnormalities in afferent-evoked synaptic responses in the ventral subiculum. These changes were not however, …
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The Role of CNTNAP2 in the Development & Evolution of the Human Cerebral Cortex
… Cntnap2 function reduces neurite branching and dendritic spine density in vitro and in vivo. The potential evolutionary significance of this gene is highlighted by the presence of eight human accelerated regions (HARs), suggesting that there are human-specific aspects to its temporal and spatial …
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Neurobiological mechanisms underlying episodic memory retrieval
… cells lacked augmented synaptic strength and dendritic spine density. We proposed that a specific pattern of connectivity of engram cells may be the crucial substrate for memory information storage and that augmented synaptic strength and spine density critically contribute to the memory …
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THE ROLE OF TRANSLATION ELONGATION DEFICITS IN ALZHEIMER’S DISEASE PATHOGENESIS
… reduced levels of eEF2K showed enhanced dendritic spine density and maturation, more postsynaptic densities (PSDs), and alterations in the expression of key synaptic plasticity-related proteins. In summary, we show that translation elongation dysregulation contributes to AD …
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Synaptic morphology, function, and regulation in a paediatric-onset neurodegenerative disorder
… of changes in the morphology and number of dendritic spines on layer 5 pyramidal neurons in the cerebral motor cortex. 2. Elucidate the biological impact of synaptic dysfunction on neuronal activity by electrophysiology. 3. Determine the underlying mechanisms contributing to dendritic spine …
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Examination of neocortical plasticity during forebrain-dependent trace-associative learning tasks
… have robustly demonstrated increased neocortical dendritic spine density following various types of general learning. Though these studies have been instrumental in revealing experience-induced and general learning-induced plasticity, the timing of the anatomical and molecular modifications …
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HIV-1 INFECTION OF NEURAL STEM CELLS RESULTS IN COGNITIVE DEFICITS THROUGH ADULT NEUROGENIC MODULATION
… neurotransmitter homeostasis, synaptodendritic damage, and calcium-mediated apoptotic pathways. At the same time, the virus may establish a state of latency in these microglia, perivascular macrophages, and astrocytes, which would allow for the long-term persistence of HIV-1 in the …