Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"dendritic morphology"”.
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WWC2 Is a Novel Regulator of GABAAR Expression, Synaptic Function, and Dendritic Morphology in Excitatory Hippocampal Neurons
… baseline synaptic function and decreased dendritic branching in hippocampal neurons. Preliminary studies indicate that CA1 pyramidal cells from WWC2 KO animals exhibit a trend toward increased stubby spine representation on basal dendrites. Additionally, I report preliminary data …
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Seasonal plasticity of A15 dopaminergic neurons in the ewe
… There were also corresponding changes in dendritic morphology including an increase in dendritic length, surface area, and number of bifurcations. Because thyroid hormones are necessary for the transition to anestrus, we next examined the role of T4 in these changes. An increase in …
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An analysis of morphological changes in visual cortical neurons after knocking down scaffolding proteins of glutamate receptors
… the two MAGUKs, this study examined changes in dendritic morphology of mouse visual cortical neurons at postnatal day 15 induced by eye opening and knocking down each of the two MAGUKs with small inhibitory RNAs (siRNAs). The changes I found include smaller cell bodies, increased frequency of …
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Dendritic biophysics and evolution
… long-standing issues limit our understanding of dendritic biophysics. In addition to distorted electrophysiological measurements, prior studies have largely been limited to ex vivo preparations from rodent animal models, providing little insight for computation in the awake human brain. In this …
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Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome
… Retardation Protein (FMRP) leads to changes in dendritic morphology and resultant cognitive and behavioral manifestations characteristic of individuals with FXS. FMRP is an RNA-binding protein that is believed to regulate the translation of a large number of other proteins, leading to a complex …
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Neural Plasticity and the Development of Intersensory Functioning in Bobwhite Quail (Colinus virginianus)
… in post-synaptic structures, particularly dendritic morphology, in brain areas responsible for vision. In avian species, the brain area responsible for vision is the visual Wulst, thought to be analogous to the mammalian visual cortex. This study examined the effects of differing amounts of …
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Stress-induced remodeling of the caenorhabditis elegans dauer
Dendrite morphology is critical to the proper function of the nervous system. Stress-induced changes to the dendritic architecture of neurons has been demonstrated in numerous mammalian and invertebrate systems; however, stress-induced remodeling of dendrites varies among neuron types. During the …
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Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder
… (COX2) results in sex-specific abnormal dendritic morphology within the cerebellum and the hippocampus as well as ASD-like behaviors including motor deficits and anxiety in mice offspring. In this study, I investigated sex-dependent effects of prenatal PGE2 exposure on hippocampal …
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Chronic Stress Effects on Prefrontal Cortical Structure and Function
… medial prefrontal (mPFC) and orbitofrontal (OFC) dendritic morphology underlie impairments in the behaviors that they subserve. Chronic stress induced a selective impairment in attentional control and a corresponding retraction of apical dendritic arbors in mPFC. By contrast, stress did not …
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Precise optical manipulation techniques for exploring neuronal function
… synapses along the three-dimensional (3D) dendritic arbour of a neuron using realistic spatio-temporal patterns of light that resemble physiological stimuli, a prerequisite to a systematic study of synaptic integration. This thesis demonstrates that holographic projection with a spatial …
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Precise optical manipulation techniques for exploring neuronal function
… synapses along the three-dimensional (3D) dendritic arbour of a neuron using realistic spatio-temporal patterns of light that resemble physiological stimuli, a prerequisite to a systematic study of synaptic integration. This thesis demonstrates that holographic projection with a spatial …
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THE CRAYFISH VISUAL SYSTEM: INTRACELLULAR STUDIES AND MORPHOLOGIES OF IDENTIFIED INTERNEURONS
… Following identification of each cell, the dendritic morphology was observed with lucifer yellow iontophoresis and subsequent fluorescence microscopy. An individual SF possesses a dendritic arborization restricted to that portion of the Medulla corresponding to its corneal receptive field. …
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Characterization of the Role of R7-RGS Proteins in Mammalian Retina and Vision
… to perturb ON bipolar cell light responses or dendritic morphology. In part iv), we found that RGS6 is expressed in starburst amacrine cells. RGS6 localization to SAC plexi is independent of R7BP. We demonstrated that, although dispensable for normal phototransduction or ON bipolar light …
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Sex differences in the effects of two-hit stress on the structure and function of rat medial prefrontal cortex
… stress challenge. In Experiment 1, I showed that dendritic remodeling of neurons in mPFC is sex-specific during the post-stress period. To assess whether these changes might give rise to functional changes, I developed a “two-hit stress” paradigm in which rats were exposed to chronic stress, given …
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Gene therapy for axon regeneration
… the soma size and resulted in more complex dendritic morphology in vitro. Consistently, the expression of constitutively activated PI3K, but not wild type PI3K, enhanced the PIP3 signaling pathway in these neurons. Importantly, overexpression of PI3Ks increased the success rate of axon …