Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"dendritic cell (DC)"”.
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Immune Checkpoint Blockade Induces Gut Microbiota Translocation That Augments Extraintestinal Anti-Tumor Immunity
… ICT induces lymph node remodeling and dendritic cell (DC) activation which facilitates the translocation of a selective subset of gut bacteria to extraintestinal tissues which promote optimal anti-tumor T-cell responses in both the tumor-draining lymph nodes (TDLN) and the primary …
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
Dendritic cell (DC) interaction with infectious prions (PrPSc) represents an important part of prion pathogenesis. Previous studies have shown that DCs are likely among the first immune cells to interact with PrPSc after oral exposure. This study looks at the initial exposure of PrPSc on DC …
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Regulation of Dendritic cell function by the ocular microenvironment
… in animal models of antigen presenting cell function. My hypothesis was that in humans the normal ocular microenvironment maintains an immature dendritic cell (DC) phenotype, whereas in intraocular inflammation (uveitis) this regulation fails, permitting full DC maturation leading to the …
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A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… the phagocyte lineages are a very heterogeneous cell compartment with specialized functions in innate immunity and induction of adaptive immune responses. Their generation from a common precursor must be tightly controlled. Interference within lineage formation programs for example by mutation or …
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Bidirectional Natural Killer Cell and Dendritic Cell Interactions in HIV-1 Pathogenesis
Natural killer (NK) and dendritic cell (DC) interactions are pivotal for the development of immune responses, which lead to bidirectional NK:DC activation. In HIV-1 infection, both NK cell and DC function are impaired, resulting in dysfunctional NK:DC crosstalk. We demonstrate that NK:DC …
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The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance
… such as proinsulin (CTB-INS) down regulates dendritic cell (DC) activation and induces the synthesis of DC immunosuppressive cytokines. Recent studies of CTB-INS induction of immune tolerance in human DCs indicate that increased IDO1 biosynthesis may play an important role in CTB-INS vaccine …
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Immunotherapy in multiple myeloma
The BDCA antibodies allowed reliable measurement of dendritic cell (DC) subsets and B cell numbers in the blood of normal subjects, and patients with MM throughout the disease course. The numbers of blood myeloid DC (BmDC) and blood plasmacytoid DC (BpDC) are low throughout the course of the …
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Characterisation of the immunomodulatory properties of human natural killer T cells
Invariant natural killer (iNKT) cells are a small subset of innate cells which express an invariant T cell receptor and NK surface molecules and recognize glycolipid antigen presented by CD1. iNKT cells have shown potent anti-tumour properties when stimulated with the iNKT cell agonist …
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Experimental brain tumors, dendritic cells and immunotherapy
… The aim of this study was to develop a dendritic cell (DC)-based vaccine for the treatment of experimental brain tumors with the future prospect of translating this treatment into the clinical application. We first demonstrated that the N29 and N32 rat brain tumors closely resemble human …
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Formulation and characterisation of cationic microparticles for the delivery of DNA vaccines
… work demonstrated the induction of antibody and cellular immune responses to HIV proteins encoded on plasmid DNA adsorbed to the particle surface in mice, guinea pigs and non-human primates (Singh et aI, 2000; O'Hagan et aI, 2001). However, the use of surfactants in microparticle formulations for …
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The Role of Apolipoprotein A-I in the Modulation of Cholesterol and Immune Homeostasis
… skin-draining lymph nodes (LNs). The LN total cell number was increased, with expansion of T cell, B cell, dendritic cell (DC) and macrophage populations. Interestingly, DKO LN T cells, B cells and DCs had increased cholesterol compared to controls. DKO LN T cells had increased expression of …
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Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
Regulatory T cells (Tregs) are a subset of CD4+ T cells with suppressive function and are critical in limiting autoimmunity. Increasing Treg numbers can be beneficial in the treatment of several inflammatory disorders. Here, we investigate the roles played by various factors on the control of Treg …
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Immune Mechanisms of Mesenchymal Stem Cell Therapy for Acute Graft versus Host Disease
… was to investigate the role of Mesenchymal stem cells (MSC) in the modulation of immune responses, focusing on suppression and induction of immune tolerance. To date, MSC therapy has proved beneficial for the treatment of inflammatory and autoimmune diseases, such as acute Graft versus Host …
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FAMIN in dendritic cells biochemically restrains T cell priming
… protected against influenza A infection, with dendritic cell (DC)- dependent excessive activation of CD8<sup>+</sup> T cell responses in their FAMIN-deficient counterparts. Loss of FAMIN activity in DCs was shown to result in increased priming of both CD4<sup>+</sup> and CD8<sup>+</sup> T cells …
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The role of innate immunity in pancreatic cancer progression and treatment
Immune cells are highly abundant in the tumour microenvironment of pancreatic ductal adenocarcinoma (PDAC) and they significantly influence the entire process of PDAC tumourigenesis. While the anti-tumour response is typically mediated by adaptive immunity, cells of the innate immune system can …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… as providing a highway for metastatic tumour cells, recent reports propose lymphatics as modulators of immunity, highlighting a need for greater understanding of immune regulation by lymphatics. The specific role of lymphatic endothelial cells (LECs) in this context, particularly in TDLNs, is …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
… in reduced tumor burden while increasing dendritic cell (DC) and T helper 1 (Th1) infiltration into the TIME. TTI-101 treatment decreased pY-STAT3 expression in tumors with accompanying increases in several NF-κB anti-tumor target genes including CXCL9, a chemokine for primed T cells. …
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The role of a pore-forming protein, Mpeg1, in cytosolic import
… process by which professional antigen presenting cells acquire exogenous antigens and present them on their surface on MHC class I molecules. This process is key for the initiation of CD8+ T cell responses. Two main pathways for cross-presentation have been described, cytosolic and vacuolar. In …
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Studies of pathogenesis, innate immunity and therapeutics of human enteric viruses in gnotobiotic pigs
… dose of LA (HiLA) induced an anti-inflammatory dendritic cell (DC) profile, characterized primarily by upregulation of TLR2 expression and production of cytokine IL-10. Conversely, low dose of LA (LoLA) upregulated TLR3 and TLR9 and increased secretion of cytokine IL-6. Additionally, HiLA …
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Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
… arms of the immune system. Innate immune cells sense the infectious threat to the host and convert it into meaningful information that is relayed to T and B cells. This relaying of information is the fundamental principle that forms the basis of all protective immune responses and is …
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