Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 86 for “"demyelination"”.
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CNS-Specific, Autoreactive CD8+ T Cells Have a Regulatory Role in Autoimmune Demyelination
… role in the pathogenesis of autoimmune demyelination. Using novel in vivo killing assays, we show that these cells retain their killing capacity and that they target both activated APC and CD4+ T cells that have been loaded with the specific antigen. These cells are also shown to produce …
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Stab Wounds to Rat Brains : Demyelination, Remyelination and the Cellular Response, Particularly of Oligodendrocytes
… cells involved in phagocytosis, the stages of demyelination, and the evidence for remyelination are of interest. Following stab wounds to rat brain cortex, corpus callosum and hippocampus, the animals were examined at 4,7,11,18,23,29,45,60 and 70 days postoperation (dpo). To help in the …
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Estrogen Depletion Effects on Myelination and Lipid Regulation within the Central Nervous System
… of a novel menopausal mouse model of demyelination and Part 2 includes conformational studies of phytate with biologically relevant metals and macrocycles. Menopause has been associated with increased neurodegeneration experienced by multiple sclerosis patients, and this dissertation …
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Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
… This axonal response of mitochondria to demyelination (ARMD) is protective, as there is an increase in energy demand due to the redistribution of sodium channels along the axon following demyelination. However, it remains to be determined how this ARMD is mounted and how mitochondrial …
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Migration of olfactory ensheathing cells grafted into adult rat spinal cord
… bromide (EtBr)-induced focal (~1 mm long) demyelination of the spinal cord white matter; 2) OECs migrate away from a focal demyelination either into normal CNS tissue or towards a second demyelinated lesion; 3) microglial reactivity is required for the generation of the migratory signal(s) …
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Investigating the role of microglial senescence in central nervous system injury and regeneration
… microglia promote remyelination following demyelination, they can become dysfunctional with ageing and neurodegenerative disease in association with impaired remyelination. The mechanisms underpinning this dysfunction are unclear. One of the hallmarks of ageing is cellular senescence, a …
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Establishment of the white matter stroke model in rats to study oligodendrogenesis
… ischemic injuries to the white matter result in demyelination leading to defective neural connection between the cerebral cortex and subcortical structures. Therefore, repair of the ischemic demyelination by enhancing endogenous oligodendrogenesis would be a plausible therapeutic approach for …
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Morphological and Physiological Examination of a Demyelinating and Remyelinating Lesion
<p>Multiple sclerosis causes demyelination of central nerve fibers, and it is this pathology which results in most of the symptoms of the disease. The repair of the fibers by remyelination has been advanced as a potential symptomatic therapy, but at present the conduction properties of remyelinated …
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Utilisation of novel magnetic resonance imaging features in the diagnosis and understanding of multiple sclerosis
… space and time. Lesions comprising inflammatory demyelination in the central nervous system are a core pathological feature of MS. Ultra-high field (e.g. 7 Tesla or 7T) T2*-weighted MRI can demonstrate in vivo a central vein in most of these lesions. This is a histopathologically specific feature …
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CNS Remyelination and the Gut Microbiota
… the microbiota of adult mice. Following focal demyelination, these mice had deficits in their inflammatory response, clearance of myelin debris and differentiation of new oligodendrocytes from oligodendrocyte progenitor cells (OPCs). Faecal microbial transplant was able to rescue aspects of the …
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Investigating the role of cellular communication network factor 3 (CCN3) in central nervous system myelination and remyelination
… the latter, two models of toxin-induced demyelination were used: cuprizone feeding and lysolecithin injection in the spinal cord ventral white matter.<br/><br/>We found that CCN3 is detected in specific anatomical regions of the healthy CNS, predominantly in neurons. Despite this …
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Frequency-Dependent Conduction Block In Demyelinating Focal Neuropathies
… conduction block across regions of focal demyelination by utilizing a conventional electrophysiological technique used frequently in the diagnosis of peripheral nerve disease. Specifically, patients with moderate to severe carpal tunnel syndrome (CTS), but, with no evidence of conduction …
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The effect of aging on myelinating gene expression and oligodendrocyte cell densities
… cell response during the recruitment (i.e., demyelination) and differentiation (i.e., remyelination) phases of myelin repair. I found that the time between 12 and 16 months of age is a critical period during which there is an age-related decrease in the number of OL lineage cells …
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The intersection of pain, disease severity, and circadian disruption in experimental autoimmune encephalomyelitis
… autoimmune disease causing neuroinflammation and demyelination to the central nervous system. The overall goal of this thesis was to explore an emerging area of research in the MS field: circadian rhythms, the 24-hour biological rhythms governing a significant number of functions at the …
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Pre-clinical Targets for Ischemic Brain Injury
… injury to oligodendrocytes, resulting in demyelination. Glutamate receptor antagonists have been trialled in stroke patients but fall short due to adverse side effects from high dose preparations. Stroke is largely a disease of ageing, and may occur in the presence of other diseases, such …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… as oligodendrocyte progenitor cells (OPCs) after demyelination in diseases such as Multiple Sclerosis (MS).A key environmental factor regulating OPC differentiation is the fate of myelin debris generated during demyelination. Myelin debris contains inhibitors of OPC differentiation and thus its …
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Alternative Neuropsychological and Magnetic Resonance Imaging Measures in Multiple Sclerosis: Exploring the relation between brain lesion measured by diffusion tensor magnetic resonance imaging and interhemispheric communication and processing speed in multiple sclerosis
… of the disease is characterised by demyelination of the white matter in the brain and central cord. MS may involve degeneration of white matter throughout the nervous system, with a predilection for specific target zones that includes the corpus callosum. The pathologic process may …
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Towards a blood-based biomarker for remyelination: Glial cell death and associated byproducts in demyelinating disease
… circulating biomarkers that may be indicative of demyelination and remyelination, as well as neuroinflammation and neurodegeneration. I did this using a combination of histology-based characterization studies in an animal model of demyelination/remyelination and analysis of clinical samples from …
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MOLECULAR TROJAN HORSES IN THE TREATMENT OF METACHROMATIC LEUKODYSTROPHY
… and is characterized by progressive and fatal demyelination in the central and peripheral nervous systems. To date, no effective treatment exists and development is hampered by the blood-brain barrier (BBB). I have successfully generated fusion proteins using an ApoE fragment as a molecular …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
… response which is pathogenic, enhancing demyelination, inflammation and disease severity. These results suggest that tolerogenic strategies for autoimmune diseases based on DNA vaccination should be approached with caution.
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