Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"delta-9-tetrahydrocannabinol"”.
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Single Liquid-Liquid Extraction of Delta-9-Tetrahydrocannabinol and 11-<i>Nor</i>-Carboxy-Delta-9-Tetrahydrocannabinol at an Acidic pH
… cases, it is important to test for both delta-9-THC and delta-9-THCA in order to determine current and recent usage. The laboratory preparation and analysis of delta-9-THC and delta-9-THCA in urine should be as cost and time efficient as possible. Current extraction of delta-9-THC and …
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The combined effects of cannabidiol and delta-9-tetrahydrocannabinol
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The influence of cannabidiol on the effects of delta-9-tetrahydrocannabinol
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effect of repeated dosing of Delta 9-Tetrahydrocannabinol, the major psychoactive ingredient of marijuana, on memory in mice
Purpose: Marijuana is the most widely used illicit drug in the United States. However, marijuana and cannabinoid derivatives have potential therapeutic uses. Studies in cannabis users have yielded contradictory results with regard to long-term effects on cognitive functions. There is no prospective …
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Preparation and Characterization of Lyophilized Cyclodextrin Complexes of a Hemisuccinate Ester of Delta-9-Tetrahydrocannabinol for Transmucosal Delivery
Delta-9- Tetrahydrocannabinol (THC) is the primary active ingredient of the plant Cannabis sativa (marijuana), responsible for the majority of the pharmacological effects. The most promising clinical applications of THC approved by the Food and Drug Administration (FDA) are for the control of …
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A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
… or its primary psychoactive constituent, delta-9-tetrahydrocannabinol (THC), is gaining acceptance. However, there are no currently approved pharmacotherapies to treat cannabinoid withdrawal. The objective of this thesis was to evaluate whether elevating endogenous anandamide levels using …
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Bedeutung des Cytochrom-P450-2C9- und -3A5-Genpolymorphismus für Pharmakokinetik, Wirkungen und Nebenwirkungen von Delta-9-Tetrahydrocannabinol bei gesunden Probanden und Probandinnen
… Drogen steht Cannabis (Hauptinhaltstoff Delta-9-THC) seit über 30 Jahren auf Platz eins in Deutschland und Europa. Des Weiteren wird THC in der Medizin zunehmend auch therapeutisch eingesetzt und ist heute Gegenstand zahlreicher Studien. Methoden: In dieser Studie untersuchten wir den …
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The pharmacological activity of the acidic, basic, and polar neutral fractions of marihuana whole smoke condensate alone, and in combination with, delta-9-tetrahydrocannabinol
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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CANNABINOIDS DELTA-9-TETRAHYDROCANNABINOL (THC) AND CP55,940 ABLATE SPECIFIC CHEMOKINE AND CYTOKINE INFLAMMATORY RESPONSE IN BV-2 MOUSE MICROGLIAL CELLS ACTIVATED WITH HIV-1 PRO-INFLAMMATORY PROTEIN TAT
Despite the widespread use of Highly Active Anti-retroviral Therapy (HAART) to combat Human Immunodeficiency Virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), HIV-Associated Neurocognitive Disorders (HANDs) still remain a dire issue. HIV can enter the brain through …
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Synthesis and Development of Potential CB1 Receptor Neutral Antagonists
… effects of cannabis use, the most common is delta-9-tetrahydrocannabinol. Cannabinoid receptors function to increase activity in the mesolimbic dopamine reward system. Dopamine is a neurotransmitter that plays a major role in addition and its regulation plays a crucial role in mental and …
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Effects of oral delta-9-tetrahydrocannibinol (THC) administration on motor activity and anxiety-like behavior in adolescent and adult Sprague-Dawley rats of both sexes
… cannabis and its primary psychoactive component delta-9-tetrahydrocannabinol (THC) may induce modifications in neural circuitry that in turn lead to adverse consequences on behavior. Previous literature has suggested that intraperitoneal, intragastric, or subcutaneous administration of THC may …
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Comparing Extraction Methods in Sample Preparation for the Quantification of Cannabinoids in Industrial Hemp
… Farm Bill) as Cannabis containing <0.3% total tetrahydrocannabinol (THC). The 2018 Farm Bill does not, however, specify standard methods for sample preparation or quantification of cannabinoids (including THC) in Cannabis. Extraction efficiency of phytochemicals is well-known to depend on the …
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… that could be linked to this observation. Delta-9-Tetrahydrocannabinol (THC) was one of the ingredients identified. However, four decades and numerous research efforts since the first observation, it has still not been concluded whether THC is effective in the treatment of glaucoma or not. …
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The Effects of Early-Life Lead Exposure on Adult Delta9-Tetrahydrocannabinol Sensitivity, Self-administration, and Tolerance
… towards cannabis (main psychoactive component delta-9-tetrahydrocannabinol) have been shifting, and many American states have legalized the recreational use of cannabis. It is also the 3rd most widely used drug of abuse in the US, and rates of cannabis use disorder are on the rise. This thesis …
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Effect of Cannabinoids and Stress on Motor Maps and Behaviour
… The last study observed the effects of delta-9-tetrahydrocannabinol (THC) on motor map expression as well as skilled and unskilled behaviour. It was discovered that THC dose dependently affected motor map expression in that a low dose of THC increased map expression while higher doses …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… agonists, including marijuana containing delta-9-tetrahydrocannabinol (THC), are found rewarding by humans. In addition to human self-reports and experimental studies that show marijuana is rewarding, contributions from preclinical studies also have implicated cannabinoid receptors in …
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Cannabinoid Modulation of Chemotaxis of Macrophages and Macrophage-like Cells
… secreted proteases. The partial agonist delta-9-tetrahydrocannabinol (THC), administered in vitro, inhibited the chemotactic response of peritoneal macrophages to the chemokine RANTES and to Acanthamoeba conditioned medium. In vivo treatment with THC also resulted in inhibition of the in …
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Antimicrobial Activity of Cannabis Extraction Products and Terpenes against Foodborne Pathogens And Use of Electrochemically Activated (ECA) Water for Control of Indoor Mold in a Cannabis Production Facility
… of Cannabidiol (CBD), and less than 0.3% of Delta 9 – Tetra Hydro Cannabinoid (THC).By definition, Cannabis sativa plants that produce less than 0.3% in dry weight of delta-9- – tetrahydrocannabinol (THC) are classified as hemp. Hemp plants are also known for producing larger amounts of …
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Effects of Δ9-Tetrahydrocannabinol on Neural Reward Anticipation Among Young Adult Cannabis Users
… on severity and chronicity of use, while acute delta-9-tetrahydrocannabinol (Δ⁹-THC) intoxication may further modulate these effects, though findings are mixed. The present study explored (1) the relationship between problematic cannabis use and neural reward anticipation, (2) the effects of …
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