Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"delivery vehicle"”.
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Development and characterisation of a heparinised fibrin hydrogel as a delivery vehicle for regenerative medicine
… of fibrin hydrogels should be carried out. As delivery of stem cells within hydrogels is a key present function of regenerative hydrogels, the impact of the heparinised fibrinogens on ADSC differentiation underwent preliminary investigation. The impact of heparin on mesenchymal stem cell …
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Formulation and characterisation of an effective particulate delivery vehicle for the novel sub-unit vaccine antigen, Ag85B-ESAT-6
… research focused on the formation of particulate delivery systems for the sub-unit fusion protein, Ag85B-ESAT-6, a promising tuberculosis (TB) vaccine candidate. Initial work concentrated on formulating and characterising, both physico-chemically and immunologically, cationic liposomes based on …
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Studies on the efficient intracellular delivery vehicle using variable region domain of a cell-penetrating anti-DNA monoclonal antibody
… the applicability of the domain as a cellular delivery vehicle. To evaluate the cell-penetrating property of 2C10 VH domain in various mammalian cell lines, the flow cytometric and confocal microscopic analysis and cell proliferation assay were used. The VH domain penetrated into all cell lines …
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Comparative analysis of cytotoxic necrotizing factor (CNF) toxins: Compatibility of cargo with delivery vehicle and identification of amino acid residues that modulate pH-dependent cytosolic cargo delivery
… are increasingly being exploited for targeted delivery in biomedical and research applications due to their potency and cell specificity. This thesis explores the suitability of the cytotoxic necrotizing factor (CNF) family as a model system for the development of Bacterial Toxin-Inspired Drug …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… of this work was the development of a novel drug delivery vehicle termed nano-in-microparticles (NIMs) to evaluate the magnetic-field dependent targeting of dry powder NIMs administered endotracheally using an ex vivo and in vivo rodent model. NIMs are a novel dry powder drug delivery vehicle …
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Amphiphilic linear-dendritic block copolymers for drug delivery
Polymeric drug delivery systems have been widely used in the pharmaceutical industry. Such systems can solubilize and sequester hydrophobic drugs from degradation, thereby increasing circulation half-life and efficacy. However, there are still challenges in the design of drug delivery vehicles to …
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Online Evaluation in WWW-Based Courseware: The Quizit System
… and test administration using the WWW as a delivery vehicle. We have applied QUIZIT in connection with our NSF-supported Education Infrastructure project on Interactive Learning with a Digital Library in Computer Science to help with evaluation in a master's level course as well as a large …
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Mathematical and Experimental Analysis of Microbicide Vaginal Gels
… which provides a physical barrier and acts as a delivery vehicle for its active ingredient. In order for the microbicide to be an effective barrier and delivery vehicle, it must have the capability to coat the epithelium for a specific amount of time and sustain its structural integrity under the …
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Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis
Nanoparticles are emerging as versatile vehicles for drug delivery, providing targeting, protection, and controlled-release capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) (PLGA) are biodegradable, exhibit tunable drug release, and have encapsulated …
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Optimized design and structural analysis of a non-pressurized manned submersible
… of fully "flooded" submersible based on a SEAL Delivery Vehicle (SDV) Design Concept. Using the design parameters determined by the mathematical model, a solid model was generated and an ANSYS goal-driven optimizer was used to further optimize the hull weldment and variable ballast tanks. When …
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Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions
… within a multidimensional biomaterial provides a delivery vehicle to areas of injury. Natural and synthetic biomaterials can be made into scaffolds to represent different types of tissues. The ratio of synthetic to natural biomaterials in the scaffold influences the interaction with MSCs. This …
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Therapeutic applications of DNA origami-based programmable nanoparticles
… have distinct advantages over other nanoparticle delivery platforms, including polymeric and lipid nanoparticles, in that they offer precise nanoscale resolution control over the attachment of therapeutic cargo, while other nanoparticle platforms only offer control over average ligand density. In …
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Development and Characterization of Viral-Based Gene Editing In Vivo
… high efficiency. AAV vectors are a preferred delivery vehicle for tissue-directed gene therapy because of their ability to achieve sustained expression from largely non-integrating episomal genomes. However, for genome editing applications, permanent expression of non-human proteins such as …
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DESIGN, DEVELOPMENT, AND FLIGHT TESTING OF A MODULAR AVIONICS AND VEHICLE MONITORING SYSTEM
… the feasibility of a low-cost rocket-powered vehicle with capabilities tailored to the needs of the Navy, such as delivering payloads, countering drones, and reliable communications, increases. The avionics bay of such a system is essential as it provides guidance and control to the vehicle …
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Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery.
… marketed by another company as a parenteral drug delivery system. The studies reported here focused on investigating SAIB as an excipient, or delivery vehicle, for use in oral delivery of several drugs, including ibuprofen, saquinavir, and clarithromycin. Dissolution experiments were conducted …
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Design and analysis of a Non-Pressurized Manned Submersible
… undeclared, covert operations. Today, the SEAL Delivery Vehicle (SDV) Mk8 Mod1 remains the United States military's most reliable and clandestine method for deploying special operations forces (SOF) to and from the maritime environment. However, the undersea missions of tomorrow are of increased …
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Making In Utero Gene Therapy Safer and More Efficient: A First Step Towards Clinical Realization
… and safety of viral vectors. A two-vector delivery system was constructed to perform cell-specific in utero gene therapy, and I showed proof-of-principle that the system functions in vitro in human and sheep cells. An Ad5 serotype adenoviral vector (Ad5) acts as the first delivery-vehicle, …
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Functionalising peptide hydrogels to improve drug delivery for the treatment of glioblastoma
… outcomes is localised, post-operative drug delivery, to bypass the BBB and directly treat cells remaining at the resection margin. Biomaterials provide a promising vehicle for these delivery systems, due to their biocompatibility, biodegradability and capacity to mimic native tissue to …
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Functionalising peptide hydrogels to improve drug delivery for the treatment of glioblastoma
… outcomes is localised, post-operative drug delivery, to bypass the BBB and directly treat cells remaining at the resection margin. Biomaterials provide a promising vehicle for these delivery systems, due to their biocompatibility, biodegradability and capacity to mimic native tissue to …
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MODIFICATION OF COMMERCIAL ROCKET MOTORS FOR TACTICAL APPLICATIONS
… School tactical rapid-response payload delivery vehicle. The modifications include a novel head-end ignition system and a tailorable nozzle end cap designed to provide reliable at-altitude ignition by improving the transient behavior of the initial combustion chamber pressure rise. The …
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