Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"delivered dose"”.
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Accumulating delivered dose to the rectum to improve toxicity prediction in prostate radiotherapy
Accumulating delivered dose to the rectum to improve toxicity prediction in prostate radiotherapy Leila E. A. Shelley Gastrointestinal (GI) toxicity is a clinical issue suffered by up to 22% of prostate cancer radiotherapy patients. However, the relationship between radiation dose and toxicity is …
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Quantifying, Understanding and Predicting Differences Between Planned and Delivered Dose to Organs at Risk in Head & Neck Cancer Patients Undergoing Radical Radiotherapy to Promote Intelligently Targeted Adaptive Radiotherapy
… Contemporary radiotherapy techniques sculpt dose to target disease and avoid organs at risk (OARs), but anatomical change during treatment mean that the radiation dose delivered to the patient – delivered dose (DA), is different to that anticipated at planning – planned dose (DP). Modifying …
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
… affects treatment efficacy by limiting dose and potentially interrupting radiation therapy. Clinical quantification of this toxicity is typically achieved by utilizing physician grading scales, assigning complication severity on an ordinal scale of symptom presentation and/or physician …
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Nanoparticle toxicokinetics in the nose: an assessment of risk
… model was developed to relate the ’delivered dose’, i.e. the number of nanoparticles reaching immortalized airway cell layers by gravitational force and diffusional mechanisms, to toxicological endpoints measured in vitro. This model was applied to a panel of rigorously characterized …
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Development of Advanced Mr-Guided Adaptive Radiation Therapy Methods For Head & Neck Cancers On The 1.5T Mr-Linac
… potential for advanced ART strategies such as dose-optimized ART, in which the treatment plan is optimized based on the accumulated dose over previous fractions, or biological image-guided ART, in which the plan is adapted based on individual tumor response as measured through quantitative …
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Adaptive Radiation Therapy Of Prostate Cancer
… before the treatment and takes into account dose delivery variation daily to compensate for the difference between planned and delivered dose. It also has potential to allow further dose escalation and margin reduction to improve the clinical outcome. This retrospective study evaluated ART …
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Assessment of Uncertainty In Planning and Dose Delivery of Proton Therapy In An Iroc- Houston Qa Phantom Due to Variable Ct Technique and Proton Energy
… in CT technique and proton energy will alter the delivered dose distributions of typical proton treatments by reducing the percent of passing pixels by 10% using a gamma analysis criteria of ±3%/5mm as measured using a heterogeneous proton QA phantom. A CT phantom used by IROC-H during therapy …
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Motion Estimation and Motion-Compensated Reconstruction for Four-Dimensional Cone Beam Computed Tomography (4D-CBCT)
… radiation therapy (SBRT) characterizing as high dose in each fraction and few fraction number requires higher accuracy for tumor localization. For organs influenced by the respiration, respiration induced motion becomes the principal cause for tumor localization uncertainty and four dimensional …
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Evaluation of Timepoint Assessment Schemes for Offline Adaptive Radiotherapy of the Head and Neck Using Velocity
… head and neck cancer treatment by reducing dose to organs at risk (OARs) and allowing margin reduction for targets. Current literature investigates predetermined and triggered adaptation, but how to trigger and how often to assess remain open questions. So, a study of adaptive assessment …
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Head and Neck Cancer Offline Adaptive Radiotherapy Proof-of-Concept Workflow for Low-Resource Clinics Utilizing NTCP
… throughout the treatment regimen, reducing dose to nearby organs at risk (OAR) whenever possible. While online ART makes use of specific and costly machinery to create daily treatment plans for patients, a lack of standardization prevents large-scale offline ART research and/or clinical …
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Towards Offline Adaptive Therapy for Prostate Patients using Velocity
… study, potentially allowing future offline dose assessment and adaptive replanning for prostate bed RT. We investigated an offline adaptive therapy workflow previously developed for head-and-neck patients on a small cohort of seven prostate patients over their first five fractions. Because …
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Development of a novel in vitro system for nasal drug delivery development
… and airflow, have a measurable effect on the delivered dose from a typical nasal pump. Similarly, adaptation of the chamber to fit under a confocal microscope, and the development of the necessary protocols has shown the effect of surface and size on the penetration of microparticulate …
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Quantifying Uncertainty In A Measurement-Based Assessment of Relative Biological Effectiveness In Carbon Ion Radiotherapy
<p>One of the largest inconsistencies in dose delivered during carbon ion therapy is due to uncertainties in relative biological effectiveness (RBE), a value that is calculated via one of several clinically implemented algorithms. This study investigates the uncertainty in measured microdosimetric …
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Incorporating range uncertainty into proton therapy treatment planning
… they are traversing, resulting in a steep dose gradient at the distal edge of the Bragg peak. These characteristics, together with advancements in computation and technology have led to the ability to plan and deliver treatments with greater conformality, sparing normal tissue and organs at …
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Real-Time Radiation Detection within the Gastrointestinal Tract
… radiation, which increases the likelihood of delivered dose discrepancies in or near the treatment area. This work overcomes this limitation by demonstrating the use of PIN diode-based ingestible electronics to monitor radiation as required throughout the gastrointestinal tract. The diode was …
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Pencil beam dose calculation for proton therapy on graphics processing units
Radiotherapy delivered using scanned beams of protons enables greater conformity between the dose distribution and the tumour than conventional radiotherapy using X rays. However, the dose distributions are more sensitive to changes in patient anatomy, and tend to deteriorate in the presence of …
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Improving Cervical Cancer Nodal Boost Radiation Therapy By Quantifying Uncertainties and Exploring Advanced Radiation Therapy Modalities
… with intact cervical cancer is frequently delivered using primary external beam radiation therapy (EBRT) followed by two fractions of intracavitary brachytherapy (ICBT). Although the tumor is the primary radiation target, controlling microscopic disease in the lymph nodes is just as …
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Improving Dose-Response Correlations For Locally Advanced Nsclc Patients Treated With Imrt Or Pspt
… patients remains below 28 months. Higher tumor dose has been found to increase survival but also a higher rate of radiation pneumonitis (RP) that affects breathing capability. In fear of such toxicity, less-aggressive treatment plans are often clinically preferred, leading to metastasis and …
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Relative Bio-Equivalence of Salbutamol MDIs Without and With the Attached Spacers. Development and validation of novel HPLC methods for the determination of salbutamol (and terbutaline) in urine excreted post-inhalation for bioequivalence and pharmacokinetic studies of Salbutamol MDIs
… in-vivo performance of three salbutamol metered dose inhalers (MDIs): Ventolin Evohaler (Evo), Airomir (Airo) and Salamol. In the in-vitro studies, critical quality attributes of the MDI using an Andersen cascade impactor (ACI) were examined and included measurement of fine particle dose (FPD) …
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Quantifying The Magnitude of to tal Dose Deviation Caused By Various Sources of Error Among Iroc Phantom Irradiation Results
… are treated like patients, and evaluation of the doses received by the thermoluminescent dosimeters (TLDs) inside the phantom, reflects the accuracy with which an institution can image, plan and irradiate a phantom or patient. Recent phantom results show that among the hundreds of various IROC …
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