Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 470 for “"deletions"”.
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Ruler arrays detect genomic insertions and deletions
… part of a mammalian sized genome for insertions, deletions, and inversions in a single experiment.
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Lower extremity features of Velocardiofacial syndrome and other 22q11 deletions
This study investigated the symptom of recurrent leg pain of unknown aetiology (PUA) in children and adolescents with 22q11 deletion. A leg pain questionnaire was designed and administered to 300 patients with 22q11 deletion and to 4507 school children. Replies were received from 119 patients …
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DIRECT REPEATS AND DELETIONS IN MITOCHONDRIAL DNA: CASUAL AND EVOLUTIONARY ASPECTS
… hybridization indicated that age-related mtDNA deletions in human, rhesus monkey and mouse arose by misalignment-dependent process involving short sequences of 4bp length.
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In Vitro Evolution of Antibody Affinity using Libraries with Insertions and Deletions
… and a small percentage of insertions/deletions (indels). Although the percentage of indels in affinity matured antibodies is low, probably due to the low rate incorporation of in-frame indels throughout the course of the SHM diversification process, it is likely that the antibody fold …
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Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and adapt long after it first emerged in 2019. As the causative agent of the coronavirus disease 2019 (COVID-19), a tremendous effort has been made to understand the molecular pathogenesis of SARS-CoV-2. Recent …
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Physiological and Molecular Consequences of Large Y Chromosome Long Arm Deletions in Mice
The mammalian Y chromosome contains genes important for male sexual maturity and reproduction. The mouse Y chromosome long arm harbours a number of multi-copy genes whose absence or reduced representation has been linked to sperm defects and offspring sex ratio distortion in favour of females. …
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Deletions- und Bruchpunktanalyse mittels Southern-Blot-Verfahren bei Familien mit Nephronophthise Typ 1 (NPH1)
… mütterliche Deletion im proximalen Bereich. Die Deletionsbruchpunkte waren durch PCR-Analyse postuliert worden. Dabei waren der klassische proximale sowie der gemeinsame distale Deletionsbruchpunkt auf Intervalle zwischen STS- Markern festgelegt worden. Der alternative proximale Bruchpunkt von …
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Changes in Trading Volume and Return Volatility Associated with S&P 500 Index Additions and Deletions
When a stock is added into the S&P 500 Index, it is automatically "cross-listed" in the index derivative markets (i.e., S&P 500 Index futures and Index options). I examined the effects of such cross-listing on the trading volume and return volatility of the underlying component stocks. Traditional …
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Share price response associated with additions to and deletions from the S&P ASX 200 share price index
In the 1970’s Managed Investment Funds began to source funds directly from the public for investment in the capital markets. The main selling feature of the funds was that they could accumulate a pool of investment capital which would then be invested to earn returns, through economies of scale, in …
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Establishment of CRISPR-Cas-based gene deletions in Bacillus methanolicus and metabolic engineering towards the production of N-methylglutamate and putrescine
… ii) construction of a plasmid library for gene deletions, iii) targeting of central metabolism genes with CRISPR interference. The results can be summarized as follows: • The CRISPR-Cas9-based system was established in _B. methanolicus_. Demonstrated by successful deletion of the _spoIIE_ gene, …
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The involvement of non-B DNA forming sequences in mediating missense mutations, micro-deletions and micro-insertions in human inherited disease
… germline missense and nonsense mutations, micro-deletions and micro-insertions causing human inherited disease and obtained from Human Gene Mutation Database (HGMD; http://www.hgmd.org) was studied in silico. A novel algorithm with a linear running time has been designed to detect the non-B DNA …
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Mutation analyses of N-terminal of brome mosaic virus polymerase-like protein by deletions, point mutations and DNA shuffling: effects on polymerase-helicase interaction
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Single-Stranded-Dna Sp6 and T7 Bacteriophage Promoter Plasmids for Engineering Mutant Rnas and Proteins: Extensions and Deletions at the Amino Terminus Which Alter the Activity of Preproparathyroid Hormone Signal Peptide
Protein engineering systems have been developed which simplify the cloning, oligonucleotide directed mutagenesis, enzymatic sequence analysis, and expression of mutant proteins, all from a single vector. Chimeric phage-plasmid expression vectors, or phagemids, containing the intergenic region of …
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Mutationen bei primären Mitochondropathien und multiple Deletionen der mitochondrialen DNA bei idiopathischen inflammatorischen Myopathien
In this study I detected deletions in the mitochondrial genome of patients with idiopathic inflammatory myopathies using long distance PCR and sequencing techniques. The deletions found are unusually large (ca. 10500-12800 bp) and show uncommon 5'-breakpoints between nt800 and nt3326 in the "minor …
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The mutation spectra of frameshift reversion ofhis4-38 in REV1 andrev1-1 strains of Saccharomyces cerevisiae
… for the reversion of his4-38 were $-$1 deletions, but +2 insertions, $-$4 deletions, $-$7 deletions and complex mutations were also observed. Ninety-five percent of the sequence alterations observed in the reversion of his4-38 were consistent with current models of frameshift …
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Engineering structural variants with prime editing
… efficiencies for both insertions and long deletions. After demonstrating that paired prime editing screens work efficiently across reporter locations, I scaled paired prime editing to regions across the genome, thereby identifying essential coding and non-coding sequences. First, I built a …
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MSCI Rebalances - Emerging Market (EM) Index
… is not consistent with the starting premise that deletions would result in a negative share performance. Trading volumes increase slightly on actual announcement date and remain at a high level on actual effective date (i.e. date that the actual index changes) for both inclusions and deletions. …
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Graph minors and algorithms
… H can be obtained from G by a series of vertex deletions, edge deletions, and edge contractions. Graph minors have been studied for several decades as a way of characterizing classes of graphs. Recent work by Robertson and Seymour has provided further motivation for studying both mathematical …
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