Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"delayed death"”.
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… which were responsible for ~435,000 of deaths annually, with >90% caused by the deadliest species, P. falciparum. Over the last two decades, global implementation of vector control and artemisinin combination therapies have resulted in significant reductions in the global burden of …
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High-throughput functionalization of the Toxoplasma kinome uncovers a novel regulator of invasion and egress
… measured by pooled screening, distinguishing delayed from acute phenotypes. A previously unstudied kinase, associated with delayed death, was shown to be a regulator of invasion and egress. I call the kinase Store Potentiating/Activating Regulatory Kinase (SPARK), based on its impact on …
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Mechanisms of persistent translation arrest following global brain ischemia and reperfusion
… for understanding why there is selective delayed death in post-ischemic neurons, however my work also gives insight into why resistant neurons survive. The results were tested in a whole animal (male Long Evans rats) model of global brain I/R using <i>in situ</i> antibodies and mRNA …
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The Effects of Synthetic and Naturally Occurring Compounds on Microsporidian Infection in Insects
… only xanthotoxin, a linear furanocoumarin, delayed death in Trichoplusia ni caterpillars infected with Vairimorpha sp. (T. ni isolate). This delay in death is due to indirect effects. Xanthotoxin does not directly inhibit microsporidian development or invasion of the host, but rather …
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Ribonomic Control During Global Brain Ischemia And Reperfusion
… to look at the mechanism behind the selective delayed death of hippocampus CA1 neurons after transient global brain ischemia. The main findings are summarized:</p> <p>1. The main form of ELAV protein family member detected in CA1/CA3 in Hu protein immunoprecipitation and polysomes was HuB …
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Time to quit? Non-genetic heterogeneity in cell fate propensity after DNA damage
… of strand breaks showed greatly induced cell death in the daughters and granddaughters of DNA damaged cells, termed delayed death. Furthermore, lineage behaviour was characterised as highly heterogeneous in when and whether cell death occurred. Complementary flow cytometric approaches …