Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"deiodinase"”.
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PCB Effects on Brain Type II 5'Deiodinase Activity in Developing Brids
PCBs are known to cause thyroid disruption in laboratory rats and are thought to be the causal agent in thyroid gland alterations in herring gulls in the Great Lakes. This study examined the regulation of thyroid hormone supply during development in (1) domestic chicken embryos (Gallus domesticus) …
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Hepatic 5'deiodinase activity of Japanese quail using reverse-T2 as substrate: assay validation, characterization, and developmental studies
… rT3, as substrate, an in vitro 5'deiodinase (5'0) assay was validated for adult Japanese quail, by defining conditions under which activity is proportional to enzyme (protein) concentration and is linear with incubation time. Activity was measured as the release of 1(125) from …
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Investigating thyroid hormone transport and regulation in chorionic somatomammotropin RNAi models of intrauterine growth restricted pregnancies
… thyroxine) and abnormal expression of placental deiodinase 2 and deiodinase 3 (DIO2/DIO3) mRNA have been implicated in IUGR. It has been reported that nutrient restricted models of IUGR pregnancies result in a decrease of thyroxine levels in maternal and fetal circulation. Transthyretin (TTR) is …
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Estado nutricional de iodo, selênio e função tireoidiana em idosos da Universidade Aberta à Terceira Idade
… acts as part of the enzyme iodothyronine 5'-deiodinase type I, thioredoxin reductase and selenoproteins. Objective – This study aimed to evaluate the nutritional status of iodine and selenium, through mean urinary concentration and thyroid function, in elderly people enrolled at the Open …
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Conservation genetics of traditional and commercial pig breeds, and evaluation of their crossbreeding potential for productivity improvement
… was assessed using a region of the iodothyronine deiodinase type 3 (DIO3) gene. This demonstrated that crossbreeding could improve future productivity, by utilising traditional variation to maximise heterozygosity in the progeny. The productivity assessment established that the traditional and …
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Extrathyroidal thyroid hormone activation in ring doves
The characteristics of 5’deiodinase (5’D) were studied in the postmitochondrial fraction (PMF) of liver homogenates from adult and developing ring doves (Streptopelia risoria). The 5’D assays were performed in the presence of abundant substrate, reverse triiodothyronine (rT3), cofactor …
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Thyroid hormone activation by intestinal tissue of high and low weight-selected chickens
… time) were established and the intestinal 5'-deiodinase (5'D) activity was characterized for comparison with other tissues. The characterization studies showed that intestinal 5'D is like the Type I 5'D in liver of birds and mammals previously studied. Specific activity of adult intestinal 5'D …
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Effects of ammonium perchlorate exposure on the thyroid function and the expression of thyroid-responsive genes in Japanese quail embryos and post hatch chicks
… evaluated by measuring the mRNA levels of Type 2 deiodinase (D2) in the brain and liver, RC3/neurogranin mRNA level in the brain and Spot 14 mRNA level in the liver. Maternal perchlorate exposure led to embryonic hypothyroidism, demonstrated by thyroid hypertrophy and very low embryonic thyroidal …
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The Effect Of Streptozotocin-induced Diabetes And Thyroid Hormone Alterations On Skeletal Muscle Contractile, Histochemical And Biochemical Properties
… or a decrease in T4-5{dollar}spprime{dollar}-deiodinase activity.;The effect of diabetes on plantaris muscle functional properties observed in this study was opposite to what would be expected in a hypothyroid state. Muscle temporal parameters were found to be significantly faster while …
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Isotopic studies of selenium in environmental samples.
… cellular membranes. The second, iodothyronine 5'-deiodinase, converts thyroxine to triiodothyronine with the release of iodine. Selenium is obtained in the diet from plant and animal products and the amount present is dependent largely on the Se content and the chemical species present in local …
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Ecotoxicogenomic New Approach Methods for Screening Development in Danio rerio
… of action (MoA): thyroid hormone activation, deiodinase inhibition, and thyroid peroxidase inhibition. The resulting transcriptomic fingerprints were distinct for each MoA, allowing for the identification of biomarkers that can differentiate between the various thyroidal MoA. <br /> …
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Expression und Regulation von Selenoproteinen in der humanen onkozytären Schilddrüsenkarzinom-Zelllinie XTC.UC1
Die Schilddrüse gehört zu den Organen mit dem höchsten Gehalt an Selen (Se). Dieses ist hauptsächlich in Form von Selenoproteinen gebunden. Hierzu gehören die 5'DI, die in den Stoffwechsel der Schilddrüsenhormone involviert ist, die TRxR, die unter anderem die Redoxstatus-abhängige Aktivität …
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Sequenzanalyse des humanen 5´-Deiodase (Typ I) -Gens bei Patienten mit Schilddrüsenfunktionsstörungen
Durch ihre Aufgaben im Metabolismus der Schilddrüsenhormone kommt der Enzymfamilie der Deiodasen im feinregulierten Zusammenspiel der Aktivierung und Inaktivierung dieser signalgebenden Stoffe eine zentrale Rolle zu. Störungen in diesem System ziehen weitreichende Folgen auf der Ebene der …