Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"deimination"”.
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… In addition, we identified and characterized deimination of linker histone H1 and found rare autoantibodies to deiminated H1 in SLE and Sjogren's syndrome patients. We also studied sera of autoimmune lupus prone mice to determine if they would recognize deiminated histones and found that …
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The role of PADs in the biogenesis of prostate cancer microvesicles which play a dysfunctional role on DC biology and the therapeutic potential of skeletal muscle microvesicles on prostate cancer cells
… cells to microvesiculate, PAD expression and deimination of cytoskeletal-actins is increased. Inhibiting the enzyme with pan-PAD inhibitor chloramidine, abrogated the deimination of cytoskeletal actins as well as reduced the release of MVs. Furthermore, combining chloramidine with anticancer …
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Identification of Roles for Peptidylarginine Deiminases (PADs) In Models of Nervous System Regeneration, Assessing Capacities of Pharmacological PAD Inhibitor Application
… (PAD1,2,3,4 and PAD6) performing citrullination (deimination) with distinct tissue localisation and target preferences. They are implicated in various inflammatory conditions, including those affecting the central nervous system (CNS). Although PAD2 and PAD4 are currently recognised as the main …
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Kinetic Characterization of the Protein Arginine Deiminase Family: Mechanistic and Inhibition Studies
<p>The family of Protein Arginine Deiminases (PADs) include five mammalian isozymes (PAD1, 2, 3, 4, and 6) that catalyze the post-traslational modification of peptidyl-arginine to peptidyl-citrulline in numerous protein substrates. This modification results in numerous physiological and …