Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"dehydrosqualene synthase"”.
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Head-to-head terpene synthases: Mechanism of action and inhibition
“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. In this work, I used x-ray crystallography, and mutagenesis to study the …
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Applications of Solid State Nuclear Magnetic Resonance Spectroscopy as a Tool for Structure Based Drug Design
… and infectious diseases. Farnesyl diphosphate synthase, which forms farnesyl diphosphate in the isoprenoid biosynthesis pathway, is an exciting new drug target because of its central role in a diverse array of biochemical pathways. Farnesyl diphosphate is a precursor in the synthesis of …
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Targeting isoprenoid biosynthesis for drug discovery
… a trans-prenyl transferase farnesyl diphosphate synthase (FPPS), and a cis-prenyl transferase undecaprenyl diphosphate synthase (UPPS). In chapter 2, I report the discovery and x-ray crystallographic structures of 10 structurally diverse compounds (benzoic/diketo/phosphonic acids, bisamidine, and …