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Showing 1 to 6 of 6 for “"dehydrophos"”.
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Investigation of the biosynthesis of the phosphonate antibiotics bialaphos and dehydrophos
… Another phosphonate presented here is antibiotic dehydrophos, which contains a unique methyl ester of a phosphonodehydroalanine group. Since the dianionic form of phosphonates at pH 7 poses a drawback with respect to their ability to mimic carboxylates and tetrahedral intermediates, esterification …
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Investigations into the biosynthesis and mode of action of the phosphonate antibiotic dehydrophos
Dehydrophos is a vinyl phosphonate tripeptide produced by Streptomyces luridus with demonstrated broad spectrum antibiotic activity. Dehydrophos antibiotic activity was determined to be dependent on uptake into the cell via non-specific oligopeptide permeases, followed by aminopeptidase catalyzed …
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Investigation of phosphonate biosynthesis: I. Structure of dehydrophos II. Mechanism of hydroxyethylphosphonate dioxygenase
… this effort through assigning the structure of dehydrophos and through investigations into the mechanism of hydroxyethylphosphonate dioxygenase. Dehydrophos was discovered as a secondary metabolite of Streptomyces luridus and was shown to have broad spectrum activity against both Gram-negative …
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Mechanistic and synthetic studies on the prochlorosin and cytolysin families of lanthipeptides
… in elucidating the biosynthetic pathways of dehydrophos, fosfazinomycin, and rhizocticin (chapter 5).
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Oxygen-dependent enzymes involved in phosphonate biosynthesis
… that are involved in the biosynthesis of dehydrophos, a compound with proven antibiotic activity, fosfazinomycin, a compound containing a unique phosphono-hydrazide linkage, and hydroxyphosphonocystoximate, a phosphonate containing an unusual thiohydroximate moiety. Here, I show that these …
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Diverse enzyme reactions in phosphonate natural product biosynthesis
… in the aerobic ocean. The tripeptide antibiotic dehydrophos consists of a phosphonate warhead attached to two proteinogenic amino acids which function to allow entry into target cells. During biosynthesis, these amino acids are transferred to the phosphonate through the action of aminoacyl-tRNA …