Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 230 for “"degradable"”.
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Fully-renewable and degradable thermoplastic elastomers.
The most common polymers derived from renewable feedstocks, poly(3-hydroxybutyrate), polyglycolide, and polylactide (PLA), have high stiffness and tensile strength, but are inherently brittle, thus limiting the potential for these polymers to replace elastic and ductile polymers derived from fossil …
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Synthetic Degradable Polymer Systems for Drug Delivery
Drug delivery technologies can play a crucial role in enhancing treatment outcomes by improving therapeutic efficacy, reducing toxicity, and increasing patient compliance. Osteoarthritis (OA) is a degenerative disease that affects all joint tissues, leading to pain and loss of mobility, with no …
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Development and applications of acid degradable polymeric materials
… was also utilized to develop acid and light degradable polyhydroxyurethane (PHU) microcapsules. The microcapsules are fabricated using interfacial polymerization with trimesoylchloride and a hydroxy acetal-bearing diamine that can undergo degradation in the absence of protic solvent. We …
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Self-amplifying degradable polyurethanes and their upcycling application
… of a novel base-triggered self-amplifying degradable polyurethane formed from an Fmoc derivative triol or Fmoc diol monomer. Firstly, Fmoc derivative diol monomer was used to synthesize a linear polymer incorporated with a base-sensitive moiety in every repeating unit to enable high …
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Towards next-generation degradable polymers via double amplification
A refinement of the existing synthetic methods in the literature was developed in order to synthesize tris(aminomethyl)ethanes from pentaerythritol. The result was a scalable, azide free route that produced tris(aminomethyl)ethanol as the trihydochloride salt in high yield. In addition to this …
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Azomethine-Containing Moieties for Simple and Degradable Conjugated Polymers
… polymers are not typically designed to be degradable and will accumulate during waste disposal without end-of-life management strategies. Therefore, there is a need to incorporate simplified and benign synthesis into the design of degradable polymers. In this vein, degradable …
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Determining rumen degradable protein requirements in growing beef cattle
… partition protein content of the diet into rumen degradable protein (RDP) and rumen undegradable protein (RUP). The segmentation of protein by rumen degradability is needed as microbial populations digest and alter feedstuffs before host utilization. Burroughs et al. (1974) proposed the …
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Lowering ruminally degradable protein in lacatating dairy cow diets
… undegraded feed protein (RUP). Ruminally degradable feed protein (RDP) is the major supplier of N for microbial protein synthesis. Most of the excess RDP will be degraded to ammonia and eliminated as urea in urine. Thus, avoiding excess RDP in dairy cattle diets is important in reducing …
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Degradable Polymers for the Controlled Delivery of Bioactive Small Molecules
Gasotransmitters are endogenous small molecule gases that are freely permeable to membranes and possess biological signaling functions. The three recognized gasotransmitters are carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S). H2S is featured in this work, as well as persulfides …
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Degradable nanocomposite preformed particle gel for chemical enhanced oil recovery applications
… mature oilfields.</p><p>The first product is a degradable nanocomposite preformed particle gel for enhanced in-depth mobility control. Three different types of degradable nanocomposite preformed particle gels were synthesized. These three nanocomposite hydrogels were made using Laponite XLG, …
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Synthesis and chemical modification of degradable polymers to enhance gene delivery
… ester)s are a class of cationic, degradable polymers that have shown significant promise as gene delivery agents, more effective than the state-of-the-art, commercially available non-viral systems. The main objective of this thesis is to synthesize new poly([beta]-amino ester)s and …
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Physico-chemical Characteristics and Environmental Fate of a Hydrolytically Degradable Cationic Flocculant
… difficult. Therefore, a novel hydrolytically degradable flocculant, poly(lactic acid) choline iodide ester methacrylate [poly(PLA4ChMA)], was developed. This is a promising alternative because further dewatering occurs as this flocculant undergoes partial hydrolytic degradation. However, the …
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Photo-responsive degradable poly (beta-amino ester) toward non-viral gene delivery
Among synthetic cationic polymers, poly(beta-amino ester) (PBAE) is one of ideal candidates for non-viral gene therapy due to its desired gene delivery efficiency, biocompatibility, and biodegradability. In order to further improve the gene delivery efficiency of PBAE by facilitating the …
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Design and synthesis of acid-cleavable monomers for chemically degradable polymeric materials
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Characterization and control of surface properties of degradable polyesters for cell culture
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Bone Marrow Stromal Cell Invasion and Bone Regeneration in Enzymatically-Degradable Osteoinductive Hydrogels
… synthetic scaffold which are enzymatically degradable and osteoinductive for bone regeneration. </p> <p> In the first part, the effect of conjugation of cell adhesion RGD peptide and osteogenic peptide KIPKA SSVPT ELSAI STLYL to a model biodegradable hydrogel on osteogenic differentiation of …
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Step-growth thiol-ene photopolymerization to form degradable, cytocompatible and multi-structural hydrogels
… rendered thiol-ene hydrogels hydrolytically degradable. Through validating model predictions with experimental results, it was found that the hydrolytic degradation of thiol-ene hydrogels was not only governed by ester bond hydrolysis, but also affected by the degree of network crosslinking. …
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Degradable polymeric nano-films and particles as delivery platforms for vaccines and immunotherapeutics
Degradable polymeric materials provide opportunities for the development of improved vaccines and immunotherapies by acting as platforms that facilitate the delivery of molecules to appropriate tissue and cellular locations to achieve therapeutic outcomes. To this end, we have designed and …
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Degradable airline scheduling : an approach to improve operational robustness and differentiate service quality
… between flight scheduling and fleet assignment (degradable schedule partitioning model), (2) with fleet assignment (degradable fleet assignment model), and (3) with aircraft routing (degradable aircraft routing model). Each problem is modeled as an integer program. Search algorithms are applied …
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