Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"deglucuronidation"”.
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Variability in fecal microbial drug deglucuronidation
… various β-glucuronidase enzymes, which catalyze deglucuronidation of compounds formed during UDP-glucuronosyltransferase (UGT) mediated phase II metabolism. Deglucuronidation can result in the formation of an inactive, active, and/or toxic compound, which may be reabsorbed into systemic …
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Investigations into the Mechanisms that Are Responsible for Reduction in Colonic SN-38 Exposure
… mediated through different efflux transporters, deglucuronidation of SN-38 glucuronide to SN-38 by bacterial β-glucuronidase secreted by commensal microbiota, generation of toxic active metabolite SN-38 from irinotecan mediated by intestinal carboxylesterse enzymes in gut and enterohepatic …