Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 405 for “"degenerative"”.
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Degenerative mechanism in dopaminergic neurons
The degenerative mechanisms of dopaminergic cells in Parkinsona??s disease (PD) remained elusive even after many years of research. However, many have hypothesized that the cell deaths in PD are via apoptosis and in particularly, by the mitochondrial-mediated apoptotic pathway. As such, the purpose …
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A Comparative Study of Degenerative Tissue
Nutrition is the earliest and most constant of vital operations. So prominent is the nutritive apparatus of an animal that the animal has been likened to a moving sac, organized to convert foreign matter into its own likeness, to which the complex organs of animal life are but auxiliaries. In …
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Somatic Mutations in Ageing and Degenerative Disease
… the development of age- related phenotypes and degenerative disease. To accurately characterise the mutational processes in normal tissues, we developed nanorate sequencing (NanoSeq), a duplex sequencing protocol with error rates of less than five errors per billion base pairs, allowing for the …
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Magnetic Resonance Based Imaging for Degenerative Cervical Myelopathy
Degenerative cervical myelopathy [DCM] is a progressive, spinal cord injury, estimated to affect 1 in 50 adults. Spinal cord compression from degenerative changes of the cervical spine, such as intervertebral disc prolapse, osteophyte formation or ligament thickening have been considered the …
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The role of Interleukin-33 in retinal degenerative diseases
… for neurovascular pathology, especially in degenerative conditions such as diabetic retinopathy (DR).<br/><br/>Interleukin-33 (IL-33) is expressed in the nuclei of Müller cells in the healthy retina. This cytokine has diverse roles in immunity and inflammation, although its role in Müller …
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Degenerative retrolisthesis: is it a compensatory mechanism for sagittal imbalance
… morphology and global sagittal balance of degenerative retrolisthesis, and to determine whether retrolisthesis is a result of spinopelvic morphology or a compensatory mechanism of global sagittal balance. Summary of Background Data: We investigated the spinopelvic morphology and global …
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Electromechanical dynamics of articular cartilage as it undergoes degenerative changes
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1983.
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Defining the genetic and molecular pathways underlying motor neuron degenerative diseases
Motor neuron degenerative diseases (MNDs) are a large group of genetically and clinically heterogeneous life-limiting disorders. MNDs are characterised by the progressive degeneration of upper and/or lower motor neurons. Unfortunately, there are currently no universal biomarker assays or …
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A patient specific total disc replacement to treat degenerative disc disease
Low back pain remains the leading cause of disability worldwide, most often arising from degeneration of the intervertebral discs (IVD). When conservative treatments fail, surgical replacement with an artificial total disc replacement (TDR) is often required. However, despite decades of refinement, …
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Parkinson's disease and degenerative parkinsonism: relationship between clinical and neurobiological aspects
Il neurovascula coupling indica il processo mediante il quale l unità neuro vascolare modula la complessa relazione tra attività neuronale, fattori emodinamici e segnali intracellulari. Recenti studi individuano la possibile associazione tra alterazioni dell emodinamica cerebrale e il decadimento …
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Engineering hiPSCs to enhance neural progenitor transplantation in degenerative cervical myelopathy
… but has yet to be evaluated as a treatment for degenerative cervical myelopathy (DCM), a non-traumatic form of spinal cord injury. Importantly, the extent of astrogliosis and extracellular matrix remodelling that could limit or enhance neural progenitor cell (NPC) graft efficacy in DCM is …
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Effects Of Altering The Peroxisomal Redox State In Models Of Degenerative Disease
<p>Peroxisomes are important regulators of cellular redox balance and function as a signaling platform to regulate anti-aging metabolic and communication networks. In addition the organelle has emerged as a major player in maintaining cellular ROS at an optimal level. At such levels, these ROS are …
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Surgery for Degenerative Mitral Valve Disease:Earlier Intervention, New Procedures, and Better Outcomes
… evolution of surgical techniques for degenerative mitral valve (MV) disease, and effects of these changes on surgical morbidity and mortality and hospital stay.Methods: From 1985 to 2010, 7,982 patients underwent surgery for degenerative mitral regurgitation; 5,045 had isolated MV …
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Two C. elegans genes that can mutate to cause degenerative cell death
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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