Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 120 for “"deformability"”.
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Erythrocyte deformability as assessed by nuclepore filters
Erythrocyte deformability characteristics were assessed by passing red cell suspensions through Nuclepore polycarbonate filters having pore diameters of 3 ym. with pore lengths of 12 ym. During flow through these filters, at a constant flow rate of 2.17 cc/min., the pressure drop across the filter …
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Jointed rock mass deformability : a probabilistic approach
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil Engineering, 1979.
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Tumor cell deformability in the metastatic cascade
… Here, we measure the physical changes in the deformability of tumor cells, indicated by the length of time required to pass through a microfluidic constriction in a suspended microchannel resonator (SMR), as related to different stages of the metastatic process-particularly, in an …
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Shear strength and deformability of rock joints
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil Engineering, 1979.
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Optical deformability : micromechanics from cell research to biomedicine
… properties of dielectric materials. This optical deformability was exploited for the measurement of cellular elasticities with a novel micromanipulation device based on a two-beam fiber-based laser trap, the optical stretcher, which can generate surface forces from 1 pN–1 nN at frequencies ranging …
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Deformability of Plasmodium falciparum parasitized red blood cells
… Several pathologic conditions alter RBC deformability that can result in abnormal circulation behavior. In the present work, altered RBC deformability caused by invading Plasmodium falciparum parasites, which are responsible for the disease malaria, is evaluated. P. falciparum parasitized …
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Ductility and deformability of FRP strengthened reinforced concrete structures
There are many structures in need of strengthening and upgrading and the need for this is due to a number of factors:<br/><br/>• Structural deterioration over time<br/>• Traffic volume increases<br/>• Increases in allowable maximum vehicle weights<br/>• Poor maintenance<br/>• Poor construction …
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The relevance of red blood cell deformability in the pathophysiology of blood disorders
… as one of the direct consequences of reduced RBC deformability. On the other hand, deformability is also indirectly impacting on RBC functionality through its complex connections with underlying molecular mechanisms. With the aid of microfabrication and microfluidic, we are able to perform …
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Deformability and Dynamics in Linear and Looped/Supercoiled DNA with Implications for Damage Sensing
… topological changes are expected to impact DNA deformability and damage recognition. We employed advanced fluorescence approaches to study protein-DNA dynamics on biologically relevant timescales, identified DNA features enabling damage recognition, and unveiled how looping/supercoiling alters …
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Applying a microfluidic 'deformability cytometry' to measure stiffness of malaria-infected red blood cells at body and febrile temperatures
… blood vessel, capillaries and splenic cords; RBC deformability is therefore crucial in maintaining normal blood circulation. During falciparum malaria, parasite proteins interact with the spectrin network of host RBCs, moderately stiffening the ring stage infected cells (rings). The subtle …
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Microfluidic devices for analysis of red blood cell mechanical properties
Decreased deformability of human red blood cells (RBCs) is both a cause of disease and biomarker for disease (1). To traverse blood capillaries, the biconcave disk-shaped RBC must deform dramatically, since the diameter of the unconstrained RBC is larger than that of the capillaries. If the RBC …
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Biophysical Studies Aimed at Potential Therapies of Hemoglobin Associated Diseases
… cell disease (SCD): oxygen affinity and RBC deformability. A Hemox Analyzer, a dual-wavelength spectrophotometer, was used to measure oxygen affinity in sRBC treated with a potential drug intended to improve oxygen affinity. Deformability, the ability of the cells to elongate when exposed to …
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Effect of Storage on the Elastic Properties of the Red Cell Membrane
… tests for predicting red blood cell survival is deformability.</p> <p>This study applies a recently developed method of measuring deformability to assess changes in stored blood. In brief, the method involves drawing a "mini" unit of blood from each of three normal healthy individuals. …
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The effects of membrane and cytoskeletal mechanics on cell adhesiveness
… Specifically, we addressed how membrane deformability, which we demonstrate is critically dependent upon tethering to the cytoskeleton, could impact a whole cell adhesion assay. To modify membrane deformability, we treated cells with the pharmacological agents phalloidin, Latrinculin B, …
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Biophysical responses of lymphocytes to environmental stress
… properties, such as mass, volume, density and deformability using a suspended microchannel resonator (SMR) can help characterize cellular behavior and physiological role. Here, we expand upon this previous work to demonstrate the necessity of measuring multiple parameters simultaneously to …
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Self-sorting of deformable particles in a microfluidic circuit
… to physical properties, including size and deformability of the particle, and can also be influenced by particle-wall interactions, hence allowing sorting based on any of these characteristics. This device could find application in cell sorting and bioseparation for therapeutics, research, …
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Creep and damage models for the service behaviour of structural members
Deformability is often a crucial to the conception of many civil-engineering structural elements. Also, design is all the more burdensome if both long- and short-term deformability has to be considered. In this thesis, long- and short-term deformability has been studied from the material and the …
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Service and Ultimate Limit State Flexural Behavior of One-Way Concrete Slabs Reinforced with Corrosion-Resistant Reinforcing Bars
… to study the structural performance and deformability of a concrete bridge deck reinforced with corrosion resistant reinforcing (CRR) bars, i.e., bars that exhibit improved corrosion resistance when embedded in concrete as compared to traditional black steel. Flexural tests of one-way …
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Label-Free Microfluidic Devices for Single-Cell Analysis and Liquid Biopsies
… samples. Biomechanical probing of cells through deformability assays provides a label-free method of identifying cell health and monitoring response to physical and chemical stimuli. Bioimpedance analysis is an alternative versatile label-free method of evaluating cell characteristics by …
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