Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"deferoxamine"”.
-
Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
… (HT), alone or combined with the iron chelator deferoxamine (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model. In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals …
-
Investigating the role of sufT in Mycobacterium abscessus using CRISPRi
… and susceptibility to the metal chelator deferoxamine. To this end, 4 sgRNAs were designed, two targeting MAB_2744c (sg2744F1, sg2744F2) and two targeting the upstream gene 2745c (sg2745F1 and sg2745F2) and used to generate 4 M. abscessus sufT knock-down strains (M. abscessus …
-
HIF-1alpha role in oxygen-dependent radio- and chemosensitivity
… effects of HIF-1α-modulating drugs (EDHB, CoCl2, deferoxamine to stabilise and R59949 to destabilise it) reflected both HIF-1α-dependent and independent mechanisms. Collectively the data show that HIF-1α played a causal role in our in vitro model of hypoxia-induced radioresistance whereas its …
-
Exploitation of underused Streptomyces through a combined metabolomics-genomics workflow to enhance natural product diversity.
… of nine identified metabolites - including deferoxamines, germicidins, undecylprodigiosin and coelichelin - as a result of different culture parameters. Therefore, the screen successfully expanded the available chemical space, so was applied to non-model Streptomyces strains. The screen was …
-
Prevention of bacterial growth in platelet products via inclusion of iron chelators
… medium after treatment with the iron chelators deferoxamine (DFO) or phytic acid. DFO significantly inhibited bacterial growth in a dose dependent manner (p < 0.009). Conversely, phytate only inhibited bacterial growth at concentrations ≥ 100 mM (p < 0.001); at ≤ 5 mM, phytate supplied S. …
-
Study of Growth and Bone Mineral Density and Factors Affecting Them in Children and Adolescents With Thalassaemia Major and Sickle Cell Disease
… and endocrine glands. This inquires injecting deferoxamine subcutaneously for 12 hours daily with a special pump. Both deferoxamine and pumps are expensive and therefore not accessible for all patients. In developing countries, the majority of transfusion-dependent patients with chronic …
-
Mechanisms of Post-hemorrhagic Hydrocephalus after Germinal Matrix Hemorrhage
… resolution by PPARγ/CD36 and iron chelation by Deferoxamine in hydrocephalus development after germinal matrix hemorrhage. Direct thrombin inhibition reduced short-term mTOR activation and ameliorated long-term post-hemorrhagic hydrocephalus development, neurocogntive deficits, and extracellular …
-
Regulation of mTORC1 Signalling and Amino Acid Uptake by Iron Availability in Caco-2 Intestinal Epithelial Cells
… health as a whole.<br/><br/>The iron chelator deferoxamine (DFO) was used to induce iron deficiency in Caco-2 cells (a cell line derived from a human colorectal carcinoma which has functional properties typical of absorptive enterocytes of the small intestine) in order to assess the effects of …
-
HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
… diphenyleneiodonium (DPI), and FWH reaction, deferoxamine (DFO), which significantly reduced ROS production. These findings were further confirmed using specific siRNAs against NOX2 and NOX4 (NADPH oxidase family). Furthermore, gp120 and MA both induced apoptosis (as evidenced by increased …