Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"deferiprone"”.
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Efficacia e sicurezza della terapia ferrochelante combinata in pazienti con talassemia major e grave sovraccarico di ferro intracardiaco
… sicurezza della terapia ferrochelante combinata (deferiprone + desferrioxamina) in una coorte di pazienti con grave siderosi del miocardio (T2*cardiaco<10 ms). Vista la differente adesione al trattamento emersa nel corso dell’osservazione, si è tuttavia reso necessario suddividere i pazienti di …
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Topical Therapies for the Management of Recalcitrant Chronic Rhinosinusitis
… a hydrogel composed of chitosan and dextran, and deferiprone, an iron chelating drug are reviewed for their potential to improve surgical outcomes. A review of sinonasal delivery devices for topical delivery of medication is presented with particular reference to intranasal nebulisers. The second …
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Prediction of Physicochemical Properties For Fe3+ Chelating Agents
… for Fe3+ along with good oral activity. Deferiprone, a typical HPO, has emerged as a prominent therapeutic, able to remove accumulated excess iron from the heart and mitochondria. However, because Deferiprone has some drawbacks of relatively high metabolic instability and a side effect of …
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Presence and Role of Acanthamoeba in Wound Infections
… is iron. The role of iron chelators, including deferiprone and selected novel compounds based on hydroxyl pyridine moiety, was studied. Findings revealed that all novel iron chelators have an antimicrobial activity against both bacteria. In addition, all novel iron chelators were able to kill …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
… and hydroxyurea) and iron chelators (deferiprone and, potentially, hydroxyurea) were able to ameliorate renal iron accumulation, oxidative stress, lipid peroxidation, and rhabdomyolysis-induced AKI in SS mice. These findings provide evidence that free iron, released from hemoglobin …
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Hinokitiol restores hemoglobinization and mitigates neurodegeneration in animals by re-establishing iron homeostasis
… mediated by an FDA-approved iron chelator deferiprone (DFP) can lead to cellular iron deficiency, leading to perturbation of neuronal homeostasis. These results not only establish that iron homeostasis is essential for proper neural functioning, but they also suggest a unique alternative to …
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Evaluation and Development of Metal-Binding Agents that Alter Copper Bioavailability
… namely clioquinol, maltol, pyridinol-n-oxide, deferiprone, and thiodeferiprone. The UV-vis spectroscopy of the Cu(II) and Cu(I) complexes of each ligand, along with calculation of their apparent binding affinities by competitive ligand titrations, are described. In addition, we determined …