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Showing 1 to 20 of 42 for “"defensin"”.
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Sequencing and functional characterization of a Latrodectus geometricus defensin, Lg-defensin
<p>Defensins are small, cysteine-rich, immune related proteins described to be the most widespread family of invertebrate antimicrobial peptides. Presently, there is limited information regarding spider defensins. In this study, a new defensin peptide was described in <em>Latrodectus geometricus, …
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Activity of Epithelial Defensin HBD-3 Against a Periodontal Pathogen
<p>Defensins are cationic (positive-charged) peptides with broad-spectrum antibiotic activity. In humans, there are two types of defensins, alpha (α) and beta (β). Human neutrophils contain four α-defensins known as Human Neutrophil Peptide (HNP) 1-4. Epithelial cells produce four β-defensins known …
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Antimicrobial Activity of Human Leukocyte Defensin HNP-4 Against Gram-negative Bacteria
… cells) contain four peptides known as alpha (α)-defensins or HNP 1-4. The peptides have broad-spectrum antibiotic activity. HNP 1-3 are major neutrophil components. They differ by only one amino acid residue. HNP-4 is found in small amounts, and has a different sequence. HNP-4 purified from …
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Visualizing the attack of bacteria by the antimicrobial peptide human defensin 5
… humans, produce antimicrobial peptides. Human defensin 5 (HD5) is a 32-aa cysteine-rich peptide produced primarily in the small intestine that exhibits broad-spectrum activity against various bacteria, fungi and viruses. In this thesis, in order to study and understand the mechanism of action …
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On the discovery and biological characterization of porcine β-Defensin 5 (pBD-5)
… Host defense peptides (HDPs), such as porcine β-defensins (pBDs), have gained attention for their immunomodulatory, microbiome-modulating, and antimicrobial properties. This thesis describes the discovery, synthesis, and biological characterization of a novel porcine β-defensin, pBD-5, and its …
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Epidermicin NI01 and human β-defensin 2 as modulators of macrophage subset responses
… of these peptides on macrophages. Human β-defensin 2 in the presence of the TLR4 agonist K12 LPS, up-regulated the release of the pro-inflammatory cytokines TNFα and IL-1β from M1- and M2-like macrophages. Conversely, epidermicin NI01 strongly up-regulated release of a number of …
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Screening auf Interaktionspartner für den hämatologischen Rezeptor PRV-1 : PRV-1 interagiert mit Decorin, C1qB und Defensin alpha 3
… konnte für die Proteine Decorin, C1qB und Defensin in vitro eine physikalische Interaktion mit PRV-1 nachgewiesen werden. Während C1qB und Defensin eine schwächere Interaktion zeigten, ließ sich für Decorin eine starke Bindung an PRV-1 nachweisen. Da die cDNA Bank oft nur ein Fragment der …
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Regulatory Regions required for β-Defensin-2 Up-regulation by Interleukin-1α in the Human Middle Ear Epithelial Cell Line
… immune cell. Among the innate immunities beta-defensin-2 is known to play an important role in the immune function of middle ear. But, it is unclear about signal transduction pathway and gene regulatory region of human betadefensin-2 (hBD-2). MATERIALS AND METHOD: The expression of hBD-2 by …
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Self-assembly of human defensin 6 and its role in innate immunity and siderophore-based strategies to target Gram-Negative bacteria
… of structural and functional properties of human defensin 6 (HD6). This peptide is produced and secreted by intestinal Paneth cells as a part of innate immune response to invading microbes. Instead of killing microbes, HD6 self-assembles into higher-order oligomers to entrap and prevent microbes …
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Molecular characterization and in vitro functional analysis of putative immunoprotective molecules in the soft tick, Ornithodoros savignyi
… 4, the tissue expression profile of O. savignyi defensin was investigated. It was found that transcription is induced following the ingestion of Gram-positive bacteria, while in the hemolymph upregulation was observed upon feeding. Furthermore, chapter 4 saw the attempts made at the RNAi mediated …
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The evolution of immune genes in tsetse flies (Glossina) and insights into tsetse-symbiont-trypanosome interactions
… three important immune genes: attacin-A (AttA), Defensin (Def) and Toll-like receptor 2 (TLR2), in relation to symbionts and parasitic interactions. This could in turn lay the foundations for genetic control methods The successful identification of novel attacin orthologues confirmed the previous …
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House Fly (Musca Domestica L.) Temporal and Spatial Immune Response to Streptococcus Pyogenes and Salmonella Typhimurium: Role of Pathogen Density in Bacterial Fate, Persistence and Transmission
… the upregulation of three antimicrobial peptides Defensin, Cecropin and Diptericin were investigated. Both bacterial dose and species affected survivability of these pathogens in the house fly alimentary canal. High dose of both species survived throughout the 24 h period. The number of viable S. …
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A study on the application of synthetic antimicrobial peptides derived from plants for the reduction of yeast spoilage in food
… barley peptide D-lp1) from the family of plant defensins, as well as their characteristics (mechanism of action, safety, stability) and applicability in various food products to reduce the growth of spoilage yeast. Both radish defensins were successful in reducing the growth of the yeast, with …
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Spatial and Temporal Immune Response in House Flies in Response to Ingestion of Bacillus Cereus and Eschericha Coli 0157-H7
… including three antimicrobial peptides (AMPs; Defensin, Diptericin, and Cecropin) and the peptidoglycan cleaving enzyme Lysozyme, were analyzed using immunofluorescent localization. Localization of B. cereus and E. coli O157:H7 at various time points correlated with evidence of lysed bacteria …
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Genomic characterization of the italian wolf (Canis lupus): the genes involved in black coat colour determination and application of microarray technique for snps detection.
… pathway component, the K locus, in which a beta-defensin protein acts as an alternative ligand for the Mc1r. This research project was conducted in collaboration with Prof. Gregory Barsh, Department of Genetics and Paediatrics, Stanford University. On the other hand, we performed analysis on a …
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Fundamental study of natural and synthetic antimicrobial peptides as novel preservatives against fungal food spoilage
… the activity of synthetic analogues of a human defensin, HBD-3, and a cowpea defensin-like peptide, Cp-thionin II, against selected species representing food contaminants, Fusarium culmorum, Penicillium expansum and Aspergillus niger. The peptides inhibit conidial germination, potentially with …
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Analysis of genetic variation in Pediculus humanus and Populus trichocarpa
… protein (PHUM500950), Spaetzle (PHUM595260), Defensin 1 (PHUM365700) and 2 (PHUM595870), Serpin (PHUM311330), Cactus (PHUM345810), Scavenger receptor A (ScavA; PHUM066640) and Apolipoprotein D (PHUM427700). Increased expression of Fibrinogen-related protein and Spaetzle, both related to the …
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MOLECULAR CHARACTERIZATION OF THE INTERACTION BETWEEN HELIANTHUS ANNUUS AND VERTICILLIUM DAHLIAE
… genes (Ha-PR-3, and Ha-PR-5), two defensin genes (Ha-PDF and Ha-CUA1) and genes encoding Ha-ACO, Ha-CHOX, Ha-GST and Ha-SCO were up-regulated by VdNEP, suggesting that multiple signaling pathways are involved in this interaction. Two SA-related genes (Ha-PAL and Ha-NML1) were …
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Examining the (patho)physiology of physiologically relevant ligands present in the male and female reproductive tracts
… identified a novel homozygous pathogenic beta-defensin 128 (DEFB128) variant in one patient and demonstrated the expression of this protein on the sperm cell surface. The second novel male infertility gene proposed from this study is the MROH2B gene identified in one patient with sperm that IVF …
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