Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"defense systems"”.
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Elucidating the molecular mechanisms of antiviral defense systems
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Mechanistic studies of Fusobacterium genetic and defense systems
… This dissertation exploits innate and adaptive defense systems present in Fusobacterium for their use as molecular tools for genome editing. Accordingly, we first investigated restriction-modification systems with a focus on the role of DNA methyltransferases and endonucleases in host defense …
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The evolutionary ecology of methylation-dependent bacterial defense systems
… which has driven the evolution of diverse host defense systems. Although recent years have seen a rapid expansion in defense system discovery, there remain considerable gaps in our understanding of the evolutionary ecology of MGEs and host defenses. Given the role of MGEs in spreading drug …
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Multi-objective combinatorial optimization problems in transportation and defense systems
… problems and their applications in system of systems architecting and railroad track inspection scheduling. In particular, multi-objective system of systems architecting problems with system flexibility and performance improvement funds have been investigated. Efficient solution methods are …
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Improving value of strategic defense systems using modular open architecture
… has been deliberately pursued in Department of Defense acquisitions of military systems for the last two decades due to its ability to save cost, improve performance, and prolong system lifespan. As defense systems grow increasingly complex and expensive, the risk of unforeseen threat …
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Self-directed work teams at Texas Instruments Defense Systems & Electronics Group
Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1994.
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Discovery and engineering of antiviral defense systems in bacteria and archaea
… have acquired a potent arsenal of molecular defense systems in order to survive. Known defense systems, such as CRISPR, have given rise to transformative technologies including genome editing. However, defense systems as a whole remain underexplored. Continued investigation of these systems …
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Stages of Concern of Defense Systems Management College Faculty about Technology-Based Education and Training
The Defense Systems Management College (DSMC) is beginning a major transition from its traditional classroom training methods to technology-based education and training. Conventional classroom courses will be rewritten and restructured to a computer-based format and be delivered on-line. According …
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The Avenger and SGT York: an examination of two air defense systems nondevelopmental item acquisition programs
With the Department of Defense's (DOD) budget continuing to be reduced, DOD acquisition managers must acquire technologically superior weapon systems within shorter time periods with less resources. One effective way to accomplish this is to utilize an NDI Acquisition program. This thesis analyzes …
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Speed Through Flexibility: Shortening the Acquisition Timeline of U.S. Defense Capabilities Using Flexible Systems
… procurement projects face a fundamental dilemma: systems designed and built today must serve the needs of the future, but future needs cannot be reliably forecasted. This reality drives the U.S. defense acquisition system, which creates and maintains defense capabilities in a constantly changing …
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Defense against network attacks using game theory
… website to accessing classified data. Effective defense against such attacks is a critical research area. In this thesis, we demonstrate how game theory can be used to devise effective defense systems. We utilize game theory for defense systems in two scenarios in this thesis. The first scenario …
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Conflict between bacteriophages and a mobile genetic element in bacterial immunity
… numerous immune strategies, so-called anti-phage defense systems. Likewise, phages encode counter-defenses that prevent the function of anti-phage defense systems. Many anti-phage defense systems are found within mobile genetic elements, like plasmids, temperate bacteriophages, and integrative and …
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Anti-phage defense as a driver of molecular innovation
… a catalyzing force for the creation of bacterial defense systems and corresponding phage evasion strategies. To counter phage predation, bacteria have developed a vast diversity of enzyme chemistries and molecular sensing mechanisms whose study has produced new biotechnological tools and insights …
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Protecting critical infrastructure systems using cyber, physical, and socio-technical models
"Critical infrastructure systems are vital to all nations, and incapacitating such systems can result in devastating impact on the general public. Therefore, it is essential to protect such systems from malicious threats. Today, the increasing interconnectedness of critical infrastructure systems …
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Investigating Army systems and Systems of Systems for value robustness
… a value robustness approach to architect defense systems and Systems of Systems (SoS). A value robust system or SoS has the ability to provide continued value to stakeholders by performing well to meet the mission intent under a variety of future contexts. The proposed approach encompasses …
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Microarray data analysis methods and their applications to gene expression data analysis for Saccharomyces cerevisiae under oxidative stress
… other oxidants and the capacity of antioxidant defense systems to remove them. These oxidants cause wide-ranging damage to macromolecules, including proteins, lipids, DNA and carbohydrates. Oxidative stress is an important pathophysiologic component of a number of diseases, such as Alzheimer's …
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Restriction-Modification and CRISPR-Cas Systems: Cooperation Between Innate and Adaptive Immunity in Prokaryotes
… and kill them. Restriction-modification (RM) systems represent one such strategy. Generally, these systems provide defense by coordinating the activities of two distinct enzymes: a restriction endonuclease and a methyltransferase. Both enzymes recognize the same short DNA sequences. The …
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