Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"defect site"”.
-
Characterization of the early stages of long bone regeneration in fractures and critical size defects in Xenopus Laevis
… or cancer irradiation can cause critical sized defects in long bones. Regeneration capabilities of most mammals in their long bones are robust in small defects such as fractures but diminish in large defects due to lack of proper cellular cues. A small animal in vivo model has been developed to …
-
A Biomechanical Analysis of One-Third Tubular Plates for the Treatment of Benign Lesions in the Distal Femur
… tubular plates for the treatment of benign defects in the medial distal metaphysis of the femur. Benign cysts are a common occurrence in long bones, and are of concern in load-bearing bones, such as the tibia and femur. These space-occupying growths are removed by curettage of the affected …
-
Gene-supplemented collagen-glycosaminoglycan scaffolds for nonviral gene delivery in articular cartilage tissue engineering
… times due to degradation or diffusion from the defect site. The goal of this thesis was to develop a method to employ type II collagen-glycosaminoglycan (CG) scaffolds for the nonviral delivery of the gene encoding for insulin-like growth factor (IGF)-I, as a novel means to provide a local, …
-
The role of the bone marrow niche and G-CSF in osteochondral repair
… cartilage by delivering bone marrow cells to the defect site. However, the specific identity or contribution of these cells to the repair process is not well understood. Mesenchymal stem/stromal cells are thought to contribute to tissue repair by either progenitor or trophic action. In the bone …
-
In vitro culture of a chondrocyte-seeded peptide hydrogel and the effects of dynamic compression
… delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds assist in providing a template for cell distribution and extracellular matrix accumulation in a three-dimensional geometry. In these studies, a self-assembling peptide …
-
Single-dose growth factor treatments to enhance cell recruitment and neotissue integration in an augmented microfracture cartilage repair model
Focal cartilage defects caused by joint injury have a limited capacity to self-repair, and if left untreated, can lead to the early onset of osteoarthritis. The current gold standard of care, microfracture surgery, induces an endogenous repair response, but typically results in poorly integrated …
-
Development of polyHIPE scaffolds for improved bone regeneration
Critical size bone defects resulting from trauma or disease are challenging to treat due to the size and shape of the defect. Autologous tissue remains the gold standard due to the superior healing potential but harvesting material is challenging due to donor site complications. We have designed a …
-
Defects, topology, and the geometric phase in condensed matter physics
… physics, particularly geometric phases and defects. The first chapter deals with pentagonal disclinations in graphene and their associated bound states. This problem had been attacked previously, using index theorems, as well as the solutions of the continuum Dirac equation. We demonstrated …
-
Flexible adaptation of iterative learning control with applications to synthetic bone graft manufacturing
… stimulate complete bone healing in a skeletal defect site and also resorb with time so that only natural tissue remains. The objective of this research is to develop methods to integrate different regions with different porous microstructures into a single scaffold; there is evidence that …
-
Injectable hyaluronic acid scaffolds for cartilage tissue engineering
… are difficult to mold to the exact shape of the defect site. Hence, the motivation of this thesis is to develop an injectable scaffold that can be administered in a minimally invasive manner, and that allows for scaffold formation in situ, naturally shaping the construct into the shape of the …
-
Layer-by-Layer Systems for Craniomaxillofacial Bone Repair
The treatment of craniomaxillofacial bone defects with drug-eluting synthetic implants is a promising treatment currently being investigated. It is becoming increasingly recognized that release rate of growth factor proteins signaling bone regeneration and vascularization is a key optimization …
-
Study of organic molecules and nano-particle/polymer composites for flash memory and switch applications
… organic molecules and nano-particle/polymer composites for flash memory and switch applications is studied in this dissertation. Facilitating data storage on individual small molecules as the approach the limits in miniaturization for ultra-high density and low power consumption media may enable …
-
Preclinical translation of therapeutic interventions for tendon injury
… of the attachment with and without localized defects ex vivo. Biomechanical tests validated that strain concentrations localize at the defect site, suggesting that defects may propagate in vivo. The final part of this aim established the cellular, structural, and biomechanical healing capacity …
-
CAFM Studies of Epitaxial Lateral Overgrowth GaN Films
… (AFM) and conductiveAFM (CAFM) to study defect sites on GaN films. In particular, these defect sites demonstrate current leakage under reverse-bias conditions that are detrimental to device fabrication. Two growth techniques that were used to improve this leakage behavior for samples in …
-
Orienting structure to serve medical functions
… requires a method for securing the hydrogel in a defect site with the same shear strength as the cartilage-bone interface. Bonding hydrogel to a titanium base that can in turn bond to bone could enable long-term fixation of the hydrogel, but current methods of forming bonds to hydrogels do not …