Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"dedifferentiation"”.
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Aging and Ventral -Visual Dedifferentiation of Perceptual Representations
… activity has been characterized by dedifferentiation of brain responses to different categories of visual stimuli such as faces and houses that typically elicit highly specialized responses in specific regions of young adult brains. Cross-category ventral visual dedifferentiation may …
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Aging and Ventral-Visual Dedifferentiation of Perceptual Representations
… activity has been characterized by dedifferentiation of brain responses to different categories of visual stimuli such as faces and houses that typically elicit highly specialized responses in specific regions of young adult brains. Cross-category ventral visual dedifferentiation may …
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Dedifferentiation of muscle cells during Trichinella spiralis infection
… of a dedicated secretory organ, alongside the dedifferentiation of the host muscle cell is an area currently under investigation. The excretory/secretory products (ESPs) produced by the worm directly into the host cell are implicated as effectors of host cell dedifferentiation, among other …
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Molecular Characterization of Early Dedifferentiation in Newt Forelimb Regeneration
… the limbs. Limb regeneration occurs via the dedifferentiation of stump tissue and the formation of a blastema, which provides the majority of cells for the regenerate. Despite all that we have learned about dedifferentiation and blastema formation, the cellular and molecular mechanisms …
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In Vitro Models of Cellular Dedifferentiation for Regenerative Medicine
… cell mass of blastocysts, or can be made by dedifferentiation of adult cells. Regenerative medicine aims to utilize the potential of stem cells to treat disease and injury. The ability to create stem cell lines from a patient's own tissues allows for transplantation without immunosuppressive …
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A study of the differentiation and dedifferentiation of three human melanoma cell lines
Pigment formation in melanocytes is the end-point of a series of biochemical reactions involving numerous melanocyte-specific proteins including, inter alia, the enzymes tyrosinase, tyrosinase-related protein-1 (TRP-1 ), tyrosinase-related protein-2 (TRP-2) and the melanosomal protein encoded by …
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BMI1 is a context-dependent tumor suppressor that is a barrier to dedifferentiation in non-small cell lung adenocarcinoma
Predictive value is expected when preclinical models of disease are used for research. However, not all models appropriately mimic the disease progression or the treatment paradigm in the clinic. This thesis addresses an epigenetic regulator, Bmi1, which acts in stem cells to maintain their …
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The role of DEL1 in chondrocyte expansion and mechanotransduction: an investigative study
… upon culture. To investigate the mechanism of dedifferentiation, chondrocytes were cultured at low density (1x104cell/cm2) and subcultured on days 9 (P1), 14 (P2) and 21 (P3). A loss of a differentiated phenotype was observed in P1 with a reduction in sphericity from 0.72±0.02 to 0.52±0.03. …
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ANALYZING THE FUNCTIONS OF PREFOLDIN COMPLEX IN NEUROBLAST HOMEOSTASIS OF DROSOPHILA MELANOGASTER
… Co-depletion of Prefoldin and Pins also induces dedifferentiation of INPs back into neuroblasts, while depletion either Prefoldin or Pins alone is insufficient to do so. Furthermore, knocking down either α- or β-tubulin in pins- mutant background results in INP dedifferentiation back into …
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Authenticity and the transformation of the Camino : an analysis of secular pilgrimage in contemporary academic literature
… research on secular pilgrimage. A trend of dedifferentiation between religious pilgrimage, secular pilgrimage and tourism is identified whereby contemporary academic literature is arguing for a broadening of the definition of pilgrimage to incorporate many disparate forms of travel and the …
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Elucidating the Role of BMI1 in Lung and Colon Tumor Maintenance and Progression
… is a highly dynamic disease characterized by dedifferentiation, heterogeneity, and plasticity. It is postulated that within heterogeneous tumor tissues, there exists a subpopulation of cells, termed cancer stem cells (CSCs), with the ability to initiate and support tumor growth, promote …
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Studying the Molecular Mechanisms for Generating Progenitor Cells during Tail Regeneration in Ambystoma mexicanum
… the role of two candidate genes in muscle fiber dedifferentiation, the homeobox containing transcription factor Msx1 and Rad, a GTP-binding protein of a new Ras-related protein family, revealed that neither seems to play a major role in muscle dedifferentiation, both in culture and in vivo. In …
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Bmp proteins in urodele myotube cell cycle re-entry and in regeneration
… response after injury in urodeles involves dedifferentiation of fully differentiated cells into proliferative cells. One well-studied example of this is the dedifferentiation of multinucleated muscle cells into mononucleate cells resembling their precursors, the myoblasts. To form these …
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MOLECULAR ASPECTS OF DIRECT SOMATIC EMBRYOGENESIS IN ALFALFA (MEDICAGO)
… which require cells to pass through a stage of dedifferentiation before they became committed to produce somatic embryos. In contrast, direct somatic embryogenesis proceeds from cells within organised tissues, such as leaves, which are termed Pre-Embryogenic Determined cells (PEDCs). Such cells …
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Purification of A Serum Factor That Triggers Cell Cycle Re-entry In Differentiated Newt Myotubes
… blastema is thought to largely derive from the dedifferentiation of various functional cell types, such as skeletal muscle, skin and cartilage. In the case of multinucleated skeletal muscle fibres, cell cycle re-entry into S-phase as well as fragmentation into mononucleated progenitors is …
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ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS
… AS FOLLOWS: STAGE A: WOUND HEALING, STAGE B: DEDIFFERENTIATION AND STAGE C: EARLY OR LATE BLASTEMA STAGE. THE CARCINOGENIC SUBSTANCES THAT ADMINISTERED (10 -15 MGR) WERE: MNNG, 4NQO, DBA AND DMN. THE MAIN CONCLUSIONS DRAWN FROM THE RESULTS ARE: A) CARCINOGENS CAUSE DELAY TO LIMB REGENERATION …
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Hypoxia-induced phenotypic modulation of human neuroblastoma cells
… studies we have found that hypoxia induces dedifferentiation of neuroblastoma cells, which implies that hypoxia evokes a more aggressive phenotype. Here we employ microarray analysis to investigate the hypoxic effects, in neuroblastoma cells, on the expression of a larger set of genes. Genes …
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Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
… and in vitro and suggest that hypoxiainduced dedifferentiation is one of the mechanisms behind hypoxia-driven malignant progression. Hypoxia was also found to significantly impair both morphological and functional differentiation of non-transformed, immortalized epithelial mammary cells grown …
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