Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"dectin-1"”.
-
Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins
… regulate the C-type lectin-like receptor dectin-1, which is essential for innate immune responses to fungal pathogens. The aim of this thesis was to firstly develop a cell line model system to investigate the mechanism by which tetraspanins inhibit dectin-1, and to secondly extend this …
-
The innate response to fungal infection
… recognises a series of specific PAMPs via the Dectin-1 and TLR2 receptors, ultimately resulting in pro and anti-inflammatory cytokine production.<br/>Following Dectin-1 activation, I show that blocking SYK activity with SYK inhibitor II<br/>prevents MAPK and NF?B signalling, causing a reduction …
-
Mold Induced Asthma: Not all Molds are Created Equal
… following A. versicolor exposure. In Dectin-1 deficient mice, A. versicolor exposure resulted in markedly attenuated IL-17A, robust AHR, and eosinophilic inflammation compared to wild type mice. A similar phenotype was observed in mice deficient in MyD88. In the absence of MyD88, …
-
Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
… release is mediated by the ?-glucan receptor dectin-1. Furthermore we show that the adaptor protein gab-2 is affected by ?-glucan and zymosan stimulation, indicating a role in dectin-1 signaling. SFK are also seen to be involved in TNF? production induced by microbial constituents, but their …
-
Reprogramming the immune environment in breast cancer via dendritic cells.
… delivery of β-glucan, a natural ligand for dectin-1 expressed on DCs, blocks the generation of iTh2 cells leading to decreased IL-13 in the tumor microenvironment and prevents breast cancer development in vivo. β-glucan inhibits OX40L expression on tumor-associated DCs which is due to a …
-
DEVELOPMENT OF PROTEIN-BASED ANTIFUNGALS
… between the Pattern Recognition Receptor Dectin1 used by immune cells to recognize the Pathogen Associated Molecular Pattern β-glucan to develop Dectin-1 based biopharmaceuticals against the common fungal pathogen Candida albicans as a model for the use of PRR-PAMP natural affinity as a …
-
The Role of the ITAM-containing CEACAM3 Receptor in the Neutrophil Response to Infection by Neisseria gonorrhoeae
… IgG-binding Fcγ receptors, the fungal receptor Dectin-1, and the bacterial-binding CEACAM3) converge functionally on the presence of the ITAM.
-
Investigating the role of the Dendritic Cell Immunoactivating Receptor in the Immune Response during Pneumocystis murina
… on the role of CLRs in Pneumocystis infection. Dectin1and Mincle have been shown to recognise Pneumocystis surface antigens with Dectin-1 recognizing β-glucans on the Pneumocystis cell wall leading to an effective immune response. However, the role of a newly described CLR, the Dendritic Cell …