Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"decompaction"”.
-
Understanding the relationship between large-scale chromatin structure and gene expression
… greater chromatin accessibility and cytological decompaction of large-scale chromatin. The striking decompaction of large-scale chromatin observed through microscopy is well documented, however, it is unclear what molecular mechanisms drive the change in structure. The aim of this thesis was to …
-
Thermal history model of the Williston Basin
… of the Bakken Formation. Application of a decompaction scheme indicates higher paleotemperatures for the Williston Basin than would be calculated without decompaction. </p><p> Calculation of depth-porosity relationships for the Bakken Formation for four wells in the North Dakota portion of …
-
Novel functions of N-acetyltransferase 10 (NAT10) in DNA repair and replication with potential implications for premature ageing syndromes
… I showed that NAT10 depletion prevents chromatin decompaction after DNA damage induction, my hypothesis is that NAT10-mediated acetylation of PARP1 is involved in chromatin decompaction to allow DNA repair. This is currently under investigation in the lab. While investigating homologous …
-
Regulation of Chromatin Multi-Scale Organization and Function by Linker Histone H1
… Here, we show that acute H1 depletion results in decompaction of the chromatin fiber, accompanied by transcriptional derepression and increased chromatin accessibility. In contrast to stable H1 knockdown, long-range chromatin structure and the epigenetic landscape are only modestly affected in our …
-
The Effect of HACE1 on RAR Protein Stability
… by RA is well understood to involve chromosome decompaction in the presence of ligand with the aid of coactivators. The mechanism of the ligand independent action of the AF-1 domain is less clear. The AF-1 domain of RARs may be regulated by interacting proteins such as HACE1. In vitro and in …
-
CRAMP1 drives linker histone expression to enable Polycomb repression
… all linker histones, which results in selective decompaction of H3K27me3-marked loci and derepression of PRC2 target genes without concomitant loss of PRC2 occupancy or enzymatic activity. Strikingly, in contrast to the broad genomic distribution previously ascribed to H1, I find that linker …
-
Regulation of polycomb repressive complexes at the neural differentiation gene Pax6
… just one hour of ERK inhibition leading to a decompaction of the Pax6 locus in the mouse embryo. One way in which local chromatin compaction is regulated is by polycomb repressive complexes. They build a machinery that deposit the histone modifications H3K27me3 and H2AK119Ub at target genes …
-
Study of the role of plant nuclear envelope and lamina-like components in nuclear and chromatin organisation using 3D imaging
… release of transcriptional silencing as well as decompaction of heterochromatic sequences. The last part of this work takes ad- vantage of available genomic sequences and RNA-seq data to explore the evolution of NE proteins in plants and propose a minimal requirement to built the simplest …
-
Cationic Glycopolymers for DNA Delivery: Cellular Internalization Mechanisms and Biological Characterization
… resulting in negatively-charged polyplexes and decompaction of intact polyplexes is observed upon interaction with GAG. PGAA polyplexes enter cells via a complex, multifaceted internalization route. Pharmacological inhibition of endocytosis and visualization by confocal microscopy reveal that …
-
Tectonic evolution of Taranaki Basin, offshore New Zealand, The
… paleobathymetry, isostatic corrections, decompaction, unfaulting, and unfolding, and yields extension and shortening rates from the deepwater to proximal Taranaki Basin. Measured Middle Cretaceous to Paleocene extension rates total 7.0% in the Northern Taranaki Basin, 5.1% in the Central …
-
Quantitative Analysis of the Structural Dynamics of Mitotic Chromosomes in Live Mammalian Cells
… Oslo had shown that PNUTS accelerates chromatin decompaction in vitro. PNUTS is thus involved in mitotic chromatin structure in vivo and in vitro, and my findings make it an interesting target for future research to understand the molecular mechanism of chromosome compaction.
-
H4K16 acetylation during embryonic stem cell differentiation
… it has been directly associated with chromatin decompaction. H4K16ac has been linked to development through its Histone Acetyltransferase, MOF. Deletion of MOF in mice leads to mass chromatin defects, and embryonic lethality prior to the blastocyst stage. I set out to understand the role of …
-
Mutational analysis of the human histone chaperone, Nap1, in nucleosome disassembly at the HTLV-1 promoter
… These modifications have been associated with decompaction of condensed chromatin, alteration of nucleosome structure, and partial or complete disassembly of the histone octamer. Our laboratory uses human T-cell leukemia virus, type 1 (HTLV-1) as a model for studying eukaryotic transcription …
-
Paleohydrogeology of the Alberta Basin, Canada
… modified to add effects of erosion and sediment decompaction, and dissolution of evaporites.</p> <p>Fluid flow results indicate the development of compaction-driven, topography-driven and buoyancy-driven flows in the basin during the 100 million year history of basin deposition, uplift and …
-
An in vivo study of chromatin compaction in human cells
… to a loss of positive charge, and concominant decompaction of chromatin. Using MS based proteomics, I have identified a list of proteins that could potentially mediate TSA-dependent chromatin compaction.<br/>
-
Characteristics and evolution of a dynamic prograding continental margin: the late Neogene Giant Foresets Formation, northern Taranaki Basin, New Zealand
… reflection profile, and backstripping and decompaction of eleven well sections, suggests that paleobathymetric relief may have been locally important in extending the duration of terrigenous sediment starvation. Six wireline facies have been identified in the Giant Foresets Formation and …