Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"decaging"”.
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Tetrazine-Triggered Bioorthogonal Decaging Reactions for Prodrug Activation
Bioorthogonal decaging reactions have emerged as a promising strategy for the spatially and temporally controlled activation of proteins and drugs. The inverse electron-demand Diels-Alder (IEDDA) reaction between tetrazines and strained alkenes exhibits high reaction rates and selectivity and has …
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Metal Mediated Mechanisms of Drug Release
… of a palladium mediated bond-cleavage or “decaging” reaction which can cause a propargyl carbamate to decompose and release an amine. This was further developed by the incorporation of a protein modification handle which allowed an amine-bearing drug to be covalently ligated to a protein by …
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Cellular metal ion sensing using DNAzymes
… strategy to enable better stability, faster decaging, or the use of long-wavelength light for decaging by using lanthanide-doped metal nanoparticles."
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Poly(α-hydroxyalkanoic acid): Polymerization methodology, materials, and applications
… to DT-diaphorase in mammalian cells. The decaging process was finely tuned and trigger responsive cell surface labeling was achieved.
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Peptide/Protein Stapling and Unstapling: Introduction and Photorelease of Isobutylene Graft
… part of the thesis describes a photoactivation decaging method of isobutylene-caged thiols through a UV-initiated thiol-ene reaction. The method was demonstrated with an isobutylene-caged cysteine, cyclic disulfide-peptide, and thiol-containing drug, all of which were rapidly and efficiently …
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CHEMICAL BIOLOGY STRATEGIES FOR THE FORMATION AND CLEAVAGE OF CHEMICAL BONDS
Chemistry plays an essential role in biological processes within all living organisms and better understanding of how specific chemical bonds can be either formed or broken gives chemical biologists opportunities to control and regulate these processes with high precision. Therefore, with growing …