Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"dearomative"”.
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Arenophile-mediated dearomative functionalization of unactivated arenes
Two photomediated dearomative methods are reported using an “arenophile” called MTAD. Arene-arenophile cycloadducts are formed by irradiation of mixtures of unactivated arenes and MTAD at cryogenic temperatures with visible light. These cycloadducts are subsequently used as substrates in …
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Total synthesis of lycoricidine via photochemical dearomative dihydroxylation
… of lycoricidine utilizing a photochemical dearomative dihydroxylation of bromobenzene. Modified Narasaka-Sharpless dihydroxylation generates a product bearing both the electrophile and nucleophile for an unprecedented transpositive Suzuki coupling. Hetero-Diels-Alder cycloaddition is used …
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Dearomative transformations in synthesis: I. Dearomative dihydroxylation with arenophiles II. Total synthesis of lycoricidine and narciclasine III. Towards the total synthesis of collybolide
… particular, there is a paucity of reactions for dearomative installation of functionality into simple arenes in a selective and mild fashion. The first chapter of this dissertation describes the development of a dearomative functionalization reaction developed by our laboratory for the regio- and …
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Total synthesis enabled by nickel-catalyzed transformations: Dearomative carboamination and methylenecyclopropane annulation
… using a novel nickel-catalyzed asymmetric dearomative carboamination reaction. This strategy relies on the ability of N-methyl-1,2,4-triazoline-3,5-dione (MTAD) to undergo a [4+2] cycloaddition with benzene to form an intermediary cycloadduct that can then be subjected to a transition metal …
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Dearomative functionalization of simple arenes: Reduction and palladium-catalyzed syn-1,4-aminofunctionalizations
… Accordingly, many unique and enabling dearomative transformations have been developed and applied to the total synthesis of complex bioactive compounds. However, a significant challenge remains to be addressed in this field. That is, simple and non-activated arenes, such as benzene and …
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Unique applications of dearomative strategies: I) arene-oxides/oxepines through a dearomative epoxidation of non-activated arenes Ii) arenophile-mediated dearomatization of pyridines Iii) solution-state electrochemical dearomatization of polystyrene
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Advances in synthetic methodology: Dearomative aminofunctionalization of arenes and high-throughput reaction discovery
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Dearomative hydroboration-enabled synthesis of idarubicinone and synthesis of minor cannabinoids and their metabolites
… Co- and Ru-catalyzed arene oxidation and a novel dearomative hydroboration. This global functionalization strategy, a combination of site-selective arene- and dearomative-functionalizations, provided the key anthracycline framework in five operations and enabled rapid and controlled access to …
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The development of dearomative functionalizations and their use in the total synthesis of bioactive natural products
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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I. Total synthesis of sesquiterpene-tropolones II. Dearomative hydroamination and application to the synthesis of aminoglycosides
The student, Chad Ungarean, accepted the attached license on 2020-12-01 at 04:52.
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Dearomative reduction of arenes through the use of arenophiles & studies towards the synthesis of cardiotonic steroids calotropin and calactin
A novel method for the dearomative reduction of arenes through the use of N,N-arenophile, MTAD, was developed. Cheap feedstock arenes undergo photocycloaddition with MTAD, and the cycloadduct can be treated further to furnish novel 1,3-cyclohexadienes or 1,4-diamino-2- cyclohexenes. The utility of …
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Stereoselective Heterocycle Synthesis via Alkene Difunctionalization: Bulky Phosphine Ligands Enable Pd-Catalyzed Arylhalogenation, Arylcyanation and Diarylation
… as substrates in order to execute the first dearomative bisfunctionalization via arylcyanation. Chapter 3 discusses the extention of the indole dearomatization methodology wherein both a dearomative syn 1,2-diarylation and a syn 1,2-arylvinylation were achieved. This methodology utilizes …
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Development of New Organic Photoredox Catalysis Driven by Visible Light
… access to indolines. However, the exiting dearomative methods largely restrict to electron-rich indoles or go through an ionic process using strong nucleophiles. Toward this end, an unprecedented organophotocatalytic process by harnessing nucleophilic radicals to react with …